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Lipofuscin: formation, effects and role of macroautophagy
Open accessAbstract
Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed.
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“Cellular senescence is associated with changes in cellular metabolism. These include upregulation of lysosomal senescence-associated β-galactosidase, a shift from oxidative phosphorylation to glycolysis [54,55] and accumulation of lipofuscin in the cytoplasm [56,57].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [56]
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Metadata
- Authors
- Höhn, A., & Grune, T.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Grune, Tilman
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 1
- Issue
- 1
- Pages
- 140-144
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC3757681
- OpenAlex
- W2018027031
- Cited by
- 298
- References
- 51
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 14 · 2023: 30 · 2022: 30 · 2021: 22 · 2020: 33 · 2019: 25 · 2018: 32 · 2017: 15 · 2016: 18 · 2015: 23 · 2014: 14 · 2013: 5
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- lipofuscin, macroautophagy, oxidative stress, aging, proteostasis, protein oxidation, proteasome, protein aggregates, transcription factor activation, cell viability, radical formation, proteasome inhibition
- MeSH terms
- Animals, Autophagy, Humans, Lipofuscin, Transcription Factors, Proteasome Endopeptidase Complex
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