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Cited by 381

The DOI matches its Crossref record; 276 of the 276 references it cites were found in a registry or an index.

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

Open access
Moura, Fabiana Andréa, de Andrade, Kívia Queiroz, dos Santos, Juliana Célia Farias, Araújo, Orlando Roberto Pimentel, Goulart, Marília Oliveira Fonseca·2015·Redox Biology
DOI 10.1016/j.redox.2015.10.006
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Abstract

Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Some of the challenges identified in this review can shed light on this fact: lack of standardization of OS biomarkers, absence of safety data and clinical trials for the chemicals and biological molecules, as well as the fact that most of the compounds were not repeatedly tested in several situations, including acute and chronic colitis. This review hopes to stimulate researchers to become more involved in this fruitful area, to warrant investigation of novel, alternative and efficacious antioxidant-based therapies.

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Metadata

Authors
Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., Araújo, O. R. P., & Goulart, M. O. F.
Venue
Redox Biology
Publisher
Elsevier BV
Published
2015-12
Volume
6
Pages
617-639
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2015.10.006
OpenAlex
W1867120196
Cited by
381
References
276
FWCI
16.24
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Antioxidant therapy for treatment of inflammatory bowel disease: Does it work? https://app.cochat.ai/papers/10.1016/j.redox.2015.10.006
The paper
Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., Araújo, O. R. P., & Goulart, M. O. F. (2015). Antioxidant therapy for treatment of inflammatory bowel disease: Does it work? Redox Biology. https://doi.org/10.1016/j.redox.2015.10.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.