The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Redox signaling during hypoxia in mammalian cells
Open accessAbstract
Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) occurs through the reversible oxidation of cysteine thiol groups, resulting in structural modifications that can change protein function profoundly. Mitochondria are an important source of ROS generation, and studies reveal that superoxide generation by the electron transport chain increases during hypoxia. Other sources of ROS, such as the NAD(P)H oxidases, may also generate oxidant signals in hypoxia. This review considers the growing body of work indicating that increased ROS signals during hypoxia are responsible for regulating the activation of protective mechanisms in diverse cell types.
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Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
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Self-citationMitochondrial reactive oxygen species trigger hypoxia-induced transcription
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Self-citationImaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
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Mitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues
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NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology
Vermot, A., Petit-Härtlein, I., Smith, S. M. E., & Fieschi, F. (2021) · Antioxidants · doi:10.3390/antiox10060890 · Cited by 766
Cano Sanchez, M., Lancel, S., Boulanger, E., & Neviere, R. (2018) · Antioxidants · doi:10.3390/antiox7080098 · Cited by 574
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Hypoxia induces rapid changes to histone methylation and reprograms chromatin
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Metadata
- Authors
- Smith, K. A., Waypa, G. B., & Schumacker, P. T.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 13
- Pages
- 228-234
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W2621074013
- Cited by
- 200
- References
- 9
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
