Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

Cited by (547)

Items 101–200 of 547

  1. RETRACTED: DUSP1 recuses diabetic nephropathy via repressing JNK‐Mff‐mitochondrial fission pathways
    Junqin Sheng, Hongyan Li, Qin Dai, Chang Lu, Min Xu, Jisheng Zhang, Jianxun Feng · 2018 · Journal of Cellular Physiology · Retracted
  2. Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives
    Zhen Luo, Jianbo Yao, Zhe Wang, Jianxiong Xu · 2023 · Journal of Translational Medicine
  3. Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway
    Zhangwei Chen, Li Su, Muyin Liu, Ming Yin, Jinxiang Chen, Youran Li, Qiyu Li, You Zhou, Yan Xia, Ao Chen et al. · 2024 · Pharmacological Research
  4. Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy
    Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang, Heng Wu · 2018 · Cellular & Molecular Biology Letters
  5. Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
    Chang Joo Oh, Min‐Ji Kim, Ji-Min Lee, Dong Hun Kim, Il‐Young Kim, Sanghee Park, Yeongmin Kim, Kyung‐Bok Lee, Sang‐Hee Lee, Chae Won Lim et al. · 2023 · Kidney International
  6. Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function
    Jiankai Zhong, Ying Tan, Jianhua Lu, Jichen Liu, Xiaochan Xiao, Pinji Zhu, Sainan Chen, Sulin Zheng, Yuying Chen, Yunzhao Hu et al. · 2019 · Redox Biology
  7. Cardioprotective Role of Melatonin in Acute Myocardial Infarction
    Zhenhong Fu, Yang Jiao, Jihang Wang, Ying Zhang, Mingzhi Shen, Russel Joseph Reiter, Qing Xi, Yundai Chen · 2020 · Frontiers in Physiology
  8. Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure
    Milton Packer · 2020 · European Heart Journal
  9. Empagliflozin restores chronic kidney disease–induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction
    Rio P. Juni, Rushd Al‐Shama, Diederik W.D. Kuster, Jolanda van der Velden, Henrike M. Hamer, Marc G. Vervloet, Etto C. Eringa, Pieter Koolwijk, Victor W.M. van Hinsbergh · 2020 · Kidney International
  10. The Pathophysiological Basis of Diabetic Cardiomyopathy Development
    Авагимян Ашот Арманович, Sergey Valentinovich Popov, Svetlana Anatolievna Shalnova · 2022 · Current Problems in Cardiology
  11. Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics
    Miyesaier Abudureyimu, Xuanming Luo, Xiang Wang, James R. Sowers, Wenshuo Wang, Junbo Ge, Jun Tao Ren, Yingmei Zhang · 2022 · Journal of Molecular Cell Biology
  12. Collagen code in tumor microenvironment: Functions, molecular mechanisms, and therapeutic implications
    Qian Zhang, Zi-Yi An, Wen G. Jiang, Weilin Jin, Xinyang He · 2023 · Biomedicine & Pharmacotherapy
  13. Mitochondrial superoxide/hydrogen peroxide: An emerging therapeutic target for metabolic diseases
    Jialong Yan, Jinyong Jiang, Lu He, Linxi Chen · 2020 · Free Radical Biology and Medicine
  14. A SGLT2 Inhibitor Dapagliflozin Alleviates Diabetic Cardiomyopathy by Suppressing High Glucose-Induced Oxidative Stress in vivo and in vitro
    Yujie Xing, Biaohu Liu, Shujun Wan, Yi Min Cheng, Si-min Zhou, Yue Sun, Xin-ming Yao, Qiang Hua, Xiang-jian Meng, Jinhan Cheng et al. · 2021 · Frontiers in Pharmacology
  15. [Retracted] Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1‐Dependent Mitophagy
    Xiaoqing Jiang, Shumin Cai, Yinghui Jin, Feng Wu, Jing He, Xixuan Wu, Ying Tan, Yu Wang · 2021 · Oxidative Medicine and Cellular Longevity · Retracted
  16. Chronic Empagliflozin Treatment Reduces Myocardial Infarct Size in Nondiabetic Mice Through STAT-3-Mediated Protection on Microvascular Endothelial Cells and Reduction of Oxidative Stress
    Panagiota Nikolaou, Panagiotis Efentakis, Fairouz Abu Qourah, Saveria Femminò, Manousos Makridakis, Zoi Kanaki, Aimilia Varela, Maria E. Tsoumani, Constantinos H. Davos, Constantinos A. Dimitriou et al. · 2020 · Antioxidants and Redox Signaling
  17. Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3
    Jin Wang, Sam Toan, Ruibing Li, Hao Zhou · 2020 · Biochemical Pharmacology
  18. Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species
    Xiaoling Li, Gregor Römer, Raphaela P. Kerindongo, Jeroen Hermanides, Martin Albrecht, Markus Werner Hollmann, Coert Jozef Zuurbier, Benedikt Preckel, Nina Claudia Weber · 2021 · International Journal of Molecular Sciences
  19. Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies
    Chen Cai, Feng Wu, Jing He, Yaoyuan Zhang, Nengxian Shi, Xiaojie Peng, Qing Ou, Ziying Li, Xiaoqing Jiang, Jiankai Zhong et al. · 2022 · International Journal of Biological Sciences
  20. Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular Mechanisms
    Rosalba La Grotta, Chiara Frigé, Giulia Matacchione, Fabiola Olivieri, Paola de Candia, Antonio Ceriello, Francesco Prattichizzo · 2022 · International Journal of Molecular Sciences
  21. Energy metabolism disorders and potential therapeutic drugs in heart failure
    Yanan He, Wei Huang, Chen Zhang, Lumeng Chen, Runchun Xu, Nan Li, Fang Wang, Li Han, Ming Yang, Dingkun Zhang · 2020 · Acta Pharmaceutica Sinica B
  22. PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance
    Rongjun Zou, Jun Tao, Jie He, Chaojie Wang, Songtao Tan, Yu Xia, Xing Chang, Ruibin Li, Ge Wang, Hao Zhou et al. · 2022 · Research
  23. NR4A1 contributes to high-fat associated endothelial dysfunction by promoting CaMKII-Parkin-mitophagy pathways
    Pei Li, Yuzhi Bai, Xia Zhao, Tian Tian, Liying Tang, Jing Ru, Yun An, Jing Wang · 2018 · Cell Stress and Chaperones
  24. SGLT2 Inhibitors: A Novel Player in the Treatment and Prevention of Diabetic Cardiomyopathy
    Na Li, Hong Zhou · 2020 · Drug Design Development and Therapy
  25. Cardiovascular Benefits from Gliflozins: Effects on Endothelial Function
    Teresa Salvatore, Alfredo Caturano, Raffaele Galiero, Anna Di Martino, Gaetana Albanese, Erica Vetrano, Celestino Sardu, Raffaele Marfella, Luca Rinaldi, Ferdinando Carlo Sasso · 2021 · Biomedicines
  26. Oxidative Stress, Inflammation, and Mitochondrial Dysfunction: A Link between Obesity and Atrial Fibrillation
    Alkora Ioana Balan, Vasile-Bogdan Halațiu, Alina Scridon · 2024 · Antioxidants
  27. AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases
    Lu, Qingguo, Li, Xuan, Liu, Jia, Sun, Xiaodong, Rousselle, Thomas, Ren, Di, Tong, Nanwei, Li, Ji · 2019 · Bioscience Reports
  28. Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies
    Tianzheng Yu, Li Wang, Lei Zhang, Patricia Anne Deuster · 2023 · Antioxidants
  29. Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway
    Xisong Wang, Qing Song · 2018 · Cellular & Molecular Biology Letters
  30. Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/β-catenin pathway and blocking mitochondrial fission
    Hao Zhao, Yongchun Luo, Lihua Chen, Zhenhai Zhang, Chunsen Shen, Yunjun Li, Ruxiang Xu · 2018 · Cell Stress and Chaperones
  31. Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function
    Habib Yaribeygi, Stephen Lawrence Atkin, Amirhossein Sahebkar · 2018 · Journal of Cellular Physiology
  32. Molecular, Cellular, and Clinical Evidence That Sodium‐Glucose Cotransporter 2 Inhibitors Act as Neurohormonal Antagonists When Used for the Treatment of Chronic Heart Failure
    Milton Packer · 2020 · Journal of the American Heart Association
  33. Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction
    Chen Li, Ying Tan, Jiandi Wu, Qinghui Ma, Shu-chang Bai, Zhangqing Xia, Xiaoliang Wan, Jianqiu Liang · 2020 · Frontiers in Cell and Developmental Biology
  34. miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission
    Lichao Pan, Lin Zhou, Weijia Yin, Jia Qi Adam Bai, Rong Liu · 2018 · International Journal of Oncology
  35. NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy
    Junqin Sheng, Hongyan Li, Qin Dai, Chang Lu, Min Xu, Jisheng Zhang, Jianxun Feng · 2018 · Cellular Physiology and Biochemistry
  36. Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response
    Namrita Kaur, Yingshu Guan, Rida Raja, Andrea Ruiz‐Velasco, Wei Liu · 2021 · Frontiers in Physiology
  37. Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs
    Pilong Shi, Minghui Li, Chao Song, Hanping Qi, Lina Ba, Yonggang Cao, Meitian Zhang, Yawen Xie, Jing Ren, Jiabi Wu et al. · 2021 · Molecular Therapy — Nucleic Acids
  38. Cardioprotection by selective SGLT-2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?
    Panagiota Nikolaou, Nikolaos Mylonas, Manousos Makridakis, Marina Makrecka‐Kuka, Aikaterini Iliou, Stelios Zerikiotis, Panagiotis Efentakis, Stavros Kampoukos, Nikolaos G Kostomitsopoulos, Reinis Vilšķe̅rsts et al. · 2022 · Basic Research in Cardiology
  39. Mitochondrial dysfunction and oxidative stress in diabetic wound
    Guoyong Jiang, Tao Jiang, Jing Chen, Haibo Yao, Renqun Mao, Xiaofan Yang, Zhenbing Chen, Wenqing Li · 2023 · Journal of Biochemical and Molecular Toxicology
  40. Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application
    Amir Mohamed Abdelhamid, Sameh Saber, Mahmoud E. Youssef, Ahmed Gaafar Ahmed Gaafar, Hanan Eissa, Marwa A. Abdel-Dayem, Mohammed Alqarni, Gaber El‐Saber Batiha, Ahmad J. Obaidullah, Mohamed Awad Shahien et al. · 2021 · Biomedicine & Pharmacotherapy
  41. Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond
    Wei Yu, De Xie, Tetsuya Yamamoto, Hidenori Koyama, Jidong Cheng · 2023 · Reviews in Endocrine and Metabolic Disorders
  42. Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats
    Takuya Koizumi, Masaya Watanabe, Takashi Yokota, Masumi Tsuda, Haruka Handa, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Hiroyuki Natsui, Takahide Kadosaka et al. · 2023 · Frontiers in Cardiovascular Medicine
  43. SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy
    Jianxun Feng, Chang Lu, Qin Dai, Junqin Sheng, Min Xu · 2018 · Cellular Physiology and Biochemistry
  44. PKM2 regulates angiogenesis of VR‐EPCs through modulating glycolysis, mitochondrial fission, and fusion
    Ranyue Ren, Jiachao Guo, Jia Yu Shi, Yong Tian, Mengwei Li, Hao Kang · 2020 · Journal of Cellular Physiology
  45. Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis
    Mahmoud E. Youssef, Eslam E. Abd El-Fattah, Amir M. Abdelhamid, Hanan Eissa, Eman G El-Ahwany, Noha A. Amin, ‏Helal F. Hetta, Mohamed H. Mahmoud, Gaber El‐Saber Batiha, Naglaa A. Gobba et al. · 2021 · Frontiers in Pharmacology
  46. Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
    Jun Chen, Jinjie Zhong, Linlin Wang, Yingying Chen · 2021 · Frontiers in Cardiovascular Medicine
  47. Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis
    Jie Min, Lin Wu, Yandong Liu, Guoliang Song, Qinqin Deng, Jin jia Wei, Wei Yu, Miyesaier Abudureyimu, Zhaohui Pei, Jun Tao Ren · 2022 · Life Sciences
  48. Dapagliflozin prevents oxidative stress-induced endothelial dysfunction via sirtuin 1 activation
    Ying Zhou, Shi Tai, Ningjie Zhang, Liyao Fu, Yongjun Wang · 2023 · Biomedicine & Pharmacotherapy
  49. Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus
    Araiz Hussain · 2025 · Cardiovascular Diabetology – Endocrinology Reports
  50. Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions
    Claudio Daniel González, María Paula Carro Negueruela, Catalina Nicora Santamarina, Roxana Resnik, María I. Vaccaro · 2021 · Cells
  51. Empagliflozin improves renal ischemia–reperfusion injury by reducing inflammation and enhancing mitochondrial fusion through AMPK–OPA1 pathway promotion
    Wenbo Yang, Xiaoli Li, Liujie He, Shuyang Zhu, Shicong Lai, Xiaopeng Zhang, Zixiong Huang, Biyue Yu, Chun‐Ping Cui, Qiang Wang · 2023 · Cellular & Molecular Biology Letters
  52. Caveolin‐1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin‐induced apoptosis by repressing Parkin‐related mitophagy and activating the ROCK1 pathway
    Yi Liu, Yili Fu, Xianoxing Hu, Shuo Chen, Jinbai Miao, Yang Wang, Ying Zhou, Yuan Zhang · 2019 · Journal of Cellular Physiology
  53. Endothelial function and dysfunction: Impact of sodium-glucose cotransporter 2 inhibitors
    Azizah Ugusman, Jaya Kumar, Amilia Aminuddin · 2021 · Pharmacology & Therapeutics
  54. L‐carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1‐Parkin ‐dependent mitophagy through the CPT1a‐PHB2‐PARL pathways
    Li Su, Muyin Liu, Jinxiang Chen, Yuqiong Chen, Ming Yin, You Zhou, Qiyu Li, Fei Xu, Youran Li, Xiaopei Yan et al. · 2023 · Acta Physiologica
  55. TRPV4-mediated mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via the Drp1-HK2 axis
    Zijian Yan, Zili He, Hongyi Jiang, Yu Zhang, Yitie Xu, Yingze Zhang · 2023 · International Immunopharmacology
  56. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells
    Genea Edwards, Guy A Perkins, Keun-young Kim A, YeEun Kong, Yonghoon Lee, Soo‐Ho Choi, Yujia Liu, Dorota Skowronska‐Krawczyk, Robert Neal Weinreb, Linda M. Zangwill et al. · 2020 · Cell Death and Disease
  57. Diabetes pathogenesis and management: the endothelium comes of age
    Kaitlin M. Love, Eugene J. Barrett, Steven K. Malin, Jane E.B. Reusch, Judith G. Regensteiner, Zhenqi Liu · 2021 · Journal of Molecular Cell Biology
  58. Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission
    Yanqing Wang, Qian Liu, Jiaying Cai, Wu Pin, Di Wang, Yundi Shi, Tianru Huyan, Jing Su, Xuejun Li, Qi Wang et al. · 2021 · European Journal of Pharmacology
  59. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway
    Hongyan Li, Jianxun Feng, Yunfang Zhang, Junxia Feng, Qi Wang, Shili Zhao, Ping Meng, Jingchun Li · 2018 · Redox Biology
  60. Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
    Xun Wu, Wenxing Cui, Wei Guo, Haixiao Liu, Jianing Luo, Lei Zhao, Hao Guo, Longlong Zheng, Hao Bai, Dayun Feng et al. · 2020 · Neuroscience Bulletin
  61. Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitus
    Ruining Zhang, Qingxing Xie, Xi Lu, Rongping Fan, Nanwei Tong · 2024 · Diabetology & Metabolic Syndrome
  62. Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction
    Michael W. Rudokas, Margaret McKay, Zeren Toksoy, Julia N. Eisen, Markus Bögner, Lawrence H. Young, Fadi G. Akar · 2024 · Cardiovascular Diabetology
  63. Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling
    Noha F. Abdelkader, Marawan A. Elbaset, Passant E. Moustafa, Sherehan M. Ibrahim · 2022 · Archives of Pharmacal Research
  64. SGLT2 inhibitor ameliorates endothelial dysfunction associated with the commonALDH2alcohol flushing variant
    Hongchao Guo, Xuan Yu, Yu Liu, David T. Paik, Johanne Marie Justesen, Mark Chandy, James W.S. Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere et al. · 2023 · Science Translational Medicine
  65. Vascular (dys)function in the failing heart
    Luca Liberale, Dirk Jan Duncker, Derek John Hausenloy, Simon C Kraler, Hans Erik Bøtker, Bruno Karl Podesser, Gerd Heusch, Petra Kleinbongard · 2025 · Nature Reviews Cardiology
  66. RETRACTED: Tanshinone IIA promotes IL2-mediated SW480 colorectal cancer cell apoptosis by triggering INF2-related mitochondrial fission and activating the Mst1-Hippo pathway
    Jun Qian, Dong Fang, Hong Lu, Yi Lin Cao, Ji Zhang, Rong Ding, Lingchang Li, Jiege Huo · 2018 · Biomedicine & Pharmacotherapy · Retracted
  67. Melatonin Attenuates Cardiac Reperfusion Stress by Improving OPA1-Related Mitochondrial Fusion in a Yap–Hippo Pathway–Dependent Manner
    Shuxian Ma, Zhenming Dong · 2018 · Journal of Cardiovascular Pharmacology
  68. Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing
    Zhen Wang, Shi-Peng Wang, Qun Shao, Peifeng Li, Yue Sun, Lan-Zi Luo, Xiuqing Yan, Ziyi Fan, Juan Hu, Jing Zhao et al. · 2019 · Free Radical Biology and Medicine
  69. Combination of melatonin and irisin ameliorates lipopolysaccharide‐induced cardiac dysfunction through suppressing the Mst1–JNK pathways
    Haichun Ouyang, Qian Li, Jiankai Zhong, Fengfan Xia, Sulin Zheng, Jianhua Lu, Yuanyan Deng, Yunzhao Hu · 2020 · Journal of Cellular Physiology
  70. RIPK3 Induces Cardiomyocyte Necroptosis via Inhibition of AMPK‐Parkin‐Mitophagy in Cardiac Remodelling after Myocardial Infarction
    Pingjun Zhu, Kun Wan, Ming Yin, Peng Hu, Yifan Que, Xin Jin Zhou, Lei Zhang, Tianzhi Li, Yingzhen Du, Guogang Xu et al. · 2021 · Oxidative Medicine and Cellular Longevity
  71. Endothelial Protection by Sodium-Glucose Cotransporter 2 Inhibitors: A Literature Review of In Vitro and In Vivo Studies
    Nikolaos Mylonas, Panagiota Nikolaou, Paschalis Karakasis, Panagiotis Stachteas, Nikolaos Fragakis, Ioanna Andreadou · 2024 · International Journal of Molecular Sciences
  72. Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe?
    Magdalene K. Montgomery · 2019 · Biology
  73. Reinterpreting Cardiorenal Protection of Renal Sodium–Glucose Cotransporter 2 Inhibitors via Cellular Life History Programming
    Angelo Avogaro, Gian Paolo Fadini, Stefano Del Prato · 2019 · Diabetes Care
  74. A complete review of empagliflozin: Most specific and potent SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus
    Gita Chawla, Krishna Kr. Chaudhary · 2019 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
  75. Amelioration of endothelial dysfunction by sodium glucose co‐transporter 2 inhibitors: pieces of the puzzle explaining their cardiovascular protection
    Xiaoling Li, Benedikt Preckel, Jeroen Hermanides, Markus Werner Hollmann, Coert Jozef Zuurbier, Nina Claudia Weber · 2022 · British Journal of Pharmacology
  76. Mitochondrial quality control in cardiac fibrosis: Epigenetic mechanisms and therapeutic strategies
    Li-Chan Lin, Bin Tu, Kai Song, Zhiyan Liu, He Sun, Yang Zhou, Ji-Ming Sha, Jingjing Yang, Zhang Ye, Jian‐Yuan Zhao et al. · 2023 · Metabolism
  77. Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating nitrative stress-mediated cardiac microvascular injury
    Xide Shi, Chao Liu, Jiangwei Chen, Shiqiang Zhou, Yajuan Li, Xingcheng Zhao, Jinliang Xing, Junhui Xue, Fengzhou Liu, Fei Li · 2023 · Cardiovascular Diabetology
  78. Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury via regulating the SIRT1-PGC1α-mitochondrial apoptosis pathway
    Jiankai Zhong, Haichun Ouyang, Mingming Sun, Jianhua Lu, Yuanlin Zhong, Ying Tan, Yunzhao Hu · 2019 · Cell Stress and Chaperones
  79. Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation
    Ren, Lulu, Han, Feifei, Xuan, Lingling, Lv, Yali, Gong, Lili, Yan, Yan, Wan, Zirui, Guo, Lifang, Liu, He, Xu, Benshan et al. · 2019 · Free Radical Biology and Medicine
  80. Mitochondria-Mediated Cardiovascular Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors
    Siarhei A. Dabravolski, Alexander D. Zhuravlev, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander Nikolaevich Orekhov · 2022 · International Journal of Molecular Sciences
  81. Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure
    Xuan Li, Elizabeth R. Flynn, Jussara Marcia do Carmo, Zhen Wang, Alexandre A. da Silva, Alan J. Mouton, Ana Carolina Mieko Omoto, Michael E. Hall, John Edward Hall · 2022 · Frontiers in Cardiovascular Medicine
  82. RETRACTED: Therapeutic effects of melatonin on cerebral ischemia reperfusion injury: Role of Yap-OPA1 signaling pathway and mitochondrial fusion
    Na Wei, Yuehua Pu, Zhonghua Yang, Yuesong Pan, Liping Liu · 2018 · Biomedicine & Pharmacotherapy · Retracted
  83. Combined treatment with DPP-4 inhibitor linagliptin and SGLT2 inhibitor empagliflozin attenuates neointima formation after vascular injury in diabetic mice
    Hiroyuki Takahashi, Takashi Nomiyama, Yuichi Terawaki, Takeshi Horikawa, Takako Kawanami, Yuriko Hamaguchi, Tomoko Tanaka, Ryoko Motonaga, Takashi Fukuda, Makito Tanabe et al. · 2019 · Biochemistry and Biophysics Reports
  84. Impact of Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitors on Arterial Stiffness and Vascular Aging—What Do We Know So Far? (A Narrative Review)
    Cristina Andreea Adam, Razvan Constantin Anghel, Dragoș Traian Marius Marcu, Ovidiu Mitu, Mihai Roca, Florin Mitu · 2022 · Life
  85. Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial
    Anna Veelen, Charlotte Andriessen, Yvo J.M. Op den Kamp, Edmundo Erazo‐Tapia, Marlies de Ligt, Julian Mevenkamp, Johanna A. Jörgensen, Esther Moonen‐Kornips, Gert Schaart, RUSSELL L. ESTERLINE et al. · 2022 · Metabolism
  86. Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis
    Junchen Guo, Shanjie Wang, Xin Hua Wan, Xiaoxuan Liu, Zeng Wang, Chenchen Liang, Zhenming Zhang, Ye Wang, Miao Yan, Pengyan Wu et al. · 2024 · Cell Communication and Signaling
  87. Dual specificity phosphatase 1 attenuates inflammation-induced cardiomyopathy by improving mitophagy and mitochondrial metabolism
    Ying Tan, Yue Zhang, Jing He, Feng Wu, Di Wu, Nengxian Shi, Weifeng Liu, Ziying Li, Wenqian Liu, Hao Zhou et al. · 2022 · Molecular Metabolism
  88. The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure
    Benjamin Werbner, Omid Mohammad Tavakoli‐Rouzbehani, Amir Nima Fatahian, Sihem Boudina · 2023 · The Journal of Cardiovascular Aging
  89. The effect of SGLT2 inhibitors on the endothelium and the microcirculation: from bench to bedside and beyond
    Kyriakos S. Dimitriadis, Eleni Adamopoulou, Nikolaos Pyrpyris, Athanasios Sakalidis, Ioannis Leontsinis, Eleni Manta, Emmanouil Mantzouranis, Eirini Beneki, Στέργιος Σουλαϊδόπουλος, D. Konstantinidis et al. · 2023 · European Heart Journal - Cardiovascular Pharmacotherapy
  90. RETRACTED: LATS2 promotes apoptosis in non-small cell lung cancer A549 cells via triggering Mff-dependent mitochondrial fission and activating the JNK signaling pathway
    Yudong Xie, Yanping Lv, Yanli Zhang, Zhenzhen Liang, Lili Han, Yiyang Xie · 2018 · Biomedicine & Pharmacotherapy · Retracted
  91. Sepsis-related myocardial injury is associated with Mst1 upregulation, mitochondrial dysfunction and the Drp1/F-actin signaling pathway
    Xiuling Shang, Jun Li, Rongguo Yu, Pengli Zhu, Yingrui Zhang, Jingqing Xu, Kaihua Chen, Min Li · 2019 · Journal of Molecular Histology
  92. Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice
    Yihai Liu, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang · 2021 · European Journal of Pharmaceutical Sciences
  93. Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
    Meicong Chen · 2023 · Toxicology Research
  94. Sodium-Glucose Cotransporter 2 Inhibitors Potentially Prevent Atrial Fibrillation by Ameliorating Ion Handling and Mitochondrial Dysfunction
    Xiaodong Peng, Linling Li, Mengxia Zhang, Qianqian Zhao, Kui Wu, Rong Bai, Yanfei Ruan, Nian Liu · 2020 · Frontiers in Physiology
  95. The role and mechanisms of microvascular damage in the ischemic myocardium
    Bang-Hao Zhao, Amanguli Ruze, Ling Zhao, Qiulin Li, Jing Yan Tang, Nilupaer Xiefukaiti, Min-Tao Gai, An-Xia Deng, Xue-Feng Shan, Xiao-Ming Gao · 2023 · Cellular and Molecular Life Sciences
  96. Mitochondrial quality control in diabetes mellitus and complications: molecular mechanisms and therapeutic strategies
    Yanling Chen, Xun Liu, Yixuan Liu, Yujia Li, Dingxiang Li, Zhigang Mei, Yihui Deng · 2025 · Cell Death and Disease
  97. SGLT2 inhibitors: a focus on cardiac benefits and potential mechanisms
    Maja D. Muric, Vladimir I. Zivkovic, Jovana Joksimović, Jasmina Z. Sretenovic, Goran Davidović, Stefan M. Simovic, Danijela Djoković, Nemanja N. Muric, Sergey Bolevich, Vladimir Lj. Jakovljevic · 2021 · Heart Failure Reviews
  98. RETRACTED: Oxidized LDL Causes Endothelial Apoptosis by Inhibiting Mitochondrial Fusion and Mitochondria Autophagy
    Jia Zheng, Chengzhi Lu · 2020 · Frontiers in Cell and Developmental Biology · Retracted
  99. Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway
    Yangyang Wang, Yipei Ding, Pengbo Sun, Wanqiu Zhang, Qilei Xin, Ningchao Wang, Yaoyun Niu, Yang Chen, Jingyi Luo, Jinghua Lu et al. · 2022 · Antioxidants
  100. Mitochondrial Dysfunction in Atrial Fibrillation—Mechanisms and Pharmacological Interventions
    Paweł Muszyński, Tomasz Andrzej Bonda · 2021 · Journal of Clinical Medicine