Do enteric neurons make hypocretin?

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118 · see citing works

Reduced Number of Hypocretin Neurons in Human Narcolepsy

Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089 · see citing works

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050 · see citing works

Orexin Synthesis and Response in the Gut

Kirchgessner, A. L., & Liu, M.-T. (1999) · Neuron · doi:10.1016/s0896-6273(00)81041-7 · Cited by 320 · see citing works

Concomitant loss of dynorphin, NARP, and orexin in narcolepsy

Crocker, A., España, R. A., Papadopoulou, M., Saper, C. B., Faraco, J., Sakurai, T., Honda, M., Mignot, E., & Scammell, T. E. (2005) · Neurology · doi:10.1212/01.wnl.0000168173.71940.ab · Cited by 301 · see citing works

Orexins/hypocretins regulate drinking behaviour1Published on the World Wide Web on 4 August 1999.1

Kunii, K., Yamanaka, A., Nambu, T., Matsuzaki, I., Goto, K., & Sakurai, T. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01884-3 · Cited by 212 · see citing works

Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas

Ouedraogo, R., Näslund, E. B., & Kirchgessner, A. L. (2003) · Diabetes · doi:10.2337/diabetes.52.1.111 · Cited by 121 · see citing works

Inhibitory Effect of Exogenous Orexin A on Gastric Emptying, Plasma Leptin, and the Distribution of Orexin and Orexin Receptors in the Gut and Pancreas in Man

Ehrström, M., Gustafsson, T. P., Finn, A., Kirchgessner, A. L., Grybäck, P., Jacobsson, H., Hellström, P. M., & Näslund, E. B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1408 · Cited by 93 · see citing works

Localization and effects of orexin on fasting motility in the rat duodenum

Näslund, E. B., Ehrström, M., Ma, J., Hellström, P. M., & Kirchgessner, A. L. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00219.2001 · Cited by 85 · see citing works

The Frustrating and Mostly Fruitless Search for an Autoimmune Cause of Narcolepsy

Scammell, T. E. (2006) · SLEEP · doi:10.1093/sleep/29.5.601 · Cited by 52 · see citing works

Immunocytochemical Detection of Orexin A in Endocrine Cells of the Developing Mouse Gut

de Miguel, M. J. S., & Burrell, M. A. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000107 · Cited by 44 · see citing works

Pharmacokinetic profile of orexin A and effects on plasma insulin and glucagon in the rat

Ehrström, M., Näslund, E. B., Levin, F., Kaur, R., Kirchgessner, A. L., Theodorsson, E., & Hellström, P. M. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.02.004 · Cited by 42 · see citing works

Orexin Receptors: Pharmacology and Therapeutic Opportunities

Scammell, T. E., & Winrow, C. J. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100528 · Cited by 379 · see citing works

The neurobiological basis of narcolepsy

Mahoney, C. E., Cogswell, A., Koralnik, I. J., & Scammell, T. E. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0097-x · Cited by 289 · see citing works

Loss of hypocretin (orexin) neurons with traumatic brain injury

Baumann, C. R., Bassetti, C. L., Valko, P. O., Haybaeck, J., Keller, M., Clark, E., Stocker, R., Tolnay, M., & Scammell, T. E. (2009) · Annals of Neurology · doi:10.1002/ana.21836 · Cited by 185 · see citing works

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

Xu, T., Yang, Y., Ward, R. J., Gao, L., & Liu, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.025 · Cited by 158 · see citing works

Sleep disorders, obesity, and aging: The role of orexin

Nixon, J. P., Mavanji, V., Butterick, T. A., Billington, C. J., Kotz, C. M., & Teske, J. A. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.001 · Cited by 134 · see citing works

Orexin Neurons Are Necessary for the Circadian Control of REM Sleep

Kántor, S., Mochizuki, T., Janisiewicz, A. M., Clark, E. L., Nishino, S., & Scammell, T. E. (2009) · SLEEP · doi:10.1093/sleep/32.9.1127 · Cited by 111 · see citing works

When do we eat? Ingestive behavior, survival, and reproductive success.

Schneider, J., Wise, J., Benton, N. A., Brozek, J., & Keen‐Rhinehart, E. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.07.005 · Cited by 107 · see citing works

Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?

Fontana, A., Gast, H., Reith, W., Recher, M., Birchler, T., & Bassetti, C. L. (2010) · Brain · doi:10.1093/brain/awq086 · Cited by 97 · see citing works

Role of orexin in the regulation of glucose homeostasis

Tsuneki, H., Wada, T., & Sasaoka, T. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02008.x · Cited by 85 · see citing works

Autonomic disturbances in narcolepsy

Plazzi, G., Moghadam, K. K., Maggi, L. S., Donadio, V. A., Vetrugno, R., Liguori, R., Zoccoli, G., Poli, F., Pizza, F., Pagotto, U., et al. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.05.002 · Cited by 83 · see citing works

Neuropeptides Controlling Energy Balance: Orexins and Neuromedins

Nixon, J. P., Kotz, C. M., Novak, C. M., Billington, C. J., & Teske, J. A. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_4 · Cited by 56 · see citing works

REM sleep, energy balance and ‘optimal foraging’

Horne, J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.12.002 · Cited by 56 · see citing works

Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review

Laburthe, M., Voisin, T., & Firar, A. E. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02035.x · Cited by 42 · see citing works

An Autoantibody in Narcolepsy Disrupts Colonic Migrating Motor Complexes

Jackson, M. W., Reed, J. H., Smith, A., & Gordon, T. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4489-08.2008 · Cited by 28 · see citing works

Immunohistochemical identification and localization of orexin A and orexin type 2 receptor in the horse gastrointestinal tract

Dall’Aglio, C., Pascucci, L., Mercati, F., Giontella, A., Pedini, V., & Ceccarelli, P. (2008) · Research in Veterinary Science · doi:10.1016/j.rvsc.2008.07.001 · Cited by 20 · see citing works

Is suvorexant a better choice than alternative hypnotics?

Kripke, D. F. (2015) · F1000Research · doi:10.12688/f1000research.6845.1 · Cited by 19 · see citing works

Orexins

Adeghate, E. A. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00007-x · Cited by 19 · see citing works

Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs

Dallâ€TMAglio, C., Pascucci, L., Mercati, F., Giontella, A., Pedini, V., Scocco, P., & Ceccarelli, P. (2009) · European Journal of Histochemistry · doi:10.4081/1221 · Cited by 16 · see citing works

Localization of the orexin system in the gastrointestinal tract of fallow deer

Dall’Aglio, C., Pascucci, L., Mercati, F., Boiti, C., & Ceccarelli, P. (2011) · Acta Histochemica · doi:10.1016/j.acthis.2011.02.006 · Cited by 14 · see citing works

Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type 1

Ægidius, H. M., Kruse, L. S., Christensen, G. L., Lorentzen, M. P., Jørgensen, N. R., Moresco, M., Pizza, F., Plazzi, G., Jennum, P., & Kornum, B. R. (2021) · Brain Communications · doi:10.1093/braincomms/fcab050 · Cited by 13 · see citing works

An overview of the orexinergic system in different animal species

Azeez, I. A., Igado, O. O., & Olopade, J. O. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00761-0 · Cited by 13 · see citing works

Orexin system expression in the gastrointestinal tract of pigs

Dall’Aglio, C., Zannoni, A., Forni, M., Bacci, M. L., Ceccarelli, P., & Boiti, C. (2013) · Research in Veterinary Science · doi:10.1016/j.rvsc.2013.02.001 · Cited by 7 · see citing works

Wide implications of a trial on pitolisant for cataplexy

Baumann, C. R. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30398-2 · Cited by 5 · see citing works

The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications

Stránský, D., Barabas, M., Šíma, M., & Slanař, O. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1831913 · Cited by 1 · see citing works

Narcolepsy: Autoimmunity or Secondary to Infection?

Fontana, A., Gast, H., & Birchler, T. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8390-9_2 · Cited by 1 · see citing works

Etude de l'implication fonctionnelle du système orexinergique dans les mécanismes physiopathogéniques de la dépression majeure

Nollet, M. (2011) · doi:10.70675/d6583b25zf214z4c33za37az96220fd3b12f

Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy

Liblau, R., Vassalli, A., Seifinejad, A., & Tafti, M. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70218-2 · Cited by 189 · see citing works

The Hypocretins (Orexins)

de Lecea, L., & Sutcliffe, J. G. (2006) · Elsevier eBooks · doi:10.1016/b978-012369442-3/50103-3 · Cited by 3 · see citing works

The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

Taheri, S., Zeitzer, J. M., & Mignot, E. J.-M. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142826 · Cited by 333 · see citing works

Molecular Characterization of Hypocretin/Orexin and Melanin Concentrating Hormone Neurons: Relevance to Narcolepsy

Peyron, C. (2006) · CRC Press eBooks · doi:10.3109/9781420019254-25 · Cited by 2 · see citing works

Narcolepsy and Autoimmunity

Taheri, S., Paterno, J., Lin, L., & Mignot, E. (2006) · Contemporary clinical neuroscience · doi:10.1385/1-59259-950-8:341 · Cited by 3 · see citing works