The safety of calcium channel blockers during pregnancy: a prospective, multicenter, observational study
Abstract
Objective To assess the safety of calcium channel blockers during the first trimester of pregnancy.Study design A multicenter (n=11), prospective observational study of the European Network of Teratology Information Services (ENTIS). The rate of major birth defects was compared between a cohort of pregnant women exposed to calcium channel blockers during the first trimester (n=299) and a control group not exposed to potential teratogens (n=806).Results Major birth defects were not more common in the study group than in the control group. Birth weight was significantly lower in exposed term newborns. There were more preterm infants in the study group than in the control group (23.8% vs. 6.5%). These adverse effects are more likely due to the underlying disease than to the medication.Conclusion This study suggests that calcium channel blockers during the first trimester of pregnancy do not represent a major teratogenic risk.
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Among calcium channel blockers, experience is greatest with verapamil, which overall appears relatively safe.
“Among the calcium channel blockers the experience is greatest with verapamil which overall appear to be relatively safe.405”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [405]
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Advances in pharmacological treatment of type 1 diabetes during pregnancy
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Chronic Hypertension and Pregnancy
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Medication Use During Pregnancy in the Intensive Care Unit
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- Authors
- Weber-Schoendorfer, C., Hannemann, D., Meister, R., Eléfant, E., Cuppers-Maarschalkerweerd, B., Arnon, J., Vial, T., Rodriguez-Pinilla, E., Clementi, M., Robert-Gnansia, E., De Santis, M., Malm, H., Dolivo, A., & Schaefer, C.
- Affiliations
- Berliner Hochschule für Technik (DE)
- Israel Ministry of Health (IL)
- Hospices Civils de Lyon (FR)
- University of Padua (IT)
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 26
- Issue
- 1
- Pages
- 24-30
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2027351405
- Cited by
- 104
- References
- 15
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 18 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Bundesinstitut für Arzneimittel und Medizinprodukte
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- calcium channel blockers, pregnancy, first trimester, teratogenicity, congenital malformations, birth weight, preterm birth, drug safety in pregnancy
- MeSH terms
- Abnormalities, Drug-Induced, Abortion, Spontaneous, Adolescent, Adult, Birth Weight, Calcium Channel Blockers, Europe, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Israel, Middle Aged, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Premature Birth
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