CoChat
Sign Up
Cited by 158

The DOI matches its Crossref record.

Kinetics of gold nanoparticles in the human placenta

Myllynen, Päivi K., Loughran, Michael J., Howard, C. Vyvyan, Sormunen, Raija, Walsh, Adrian A., Vähäkangas, Kirsi H.·2008·Reproductive Toxicology
DOI 10.1016/j.reprotox.2008.06.008
Open this paper in CoChat — free account

Abstract

We studied the transfer of PEGylated gold nanoparticles through perfused human placenta. In 'once-through' perfusions using 15 and 30nm nanoparticles both maternal and fetal outflows were collected. Recirculating perfusions using 10 or 15nm nanoparticles lasted 6h. The gold concentration in samples was analysed on ICP-MS. The reference compound antipyrine crossed the placenta rapidly, as expected. In open perfusions nanoparticles were detected in maternal but not in fetal outflow, suggesting the lack of placental transfer. During 6h re-circulating perfusions, no particles were detected in fetal circulation. Using transmission electron microscopy (TEM) and silver enhancement, nanoparticles could be visualized in the placental tissue mainly in the trophoblastic cell layer. In in vitro experiments, nanoparticles were taken up by BeWo choriocarcinoma cells and retained inside the cells for an extended period of 48h. In conclusion, PEGylated gold nanoparticles of the size 10-30nm did not cross the perfused human placenta in detectable amounts into the fetal circulation within 6h. Whether PEGylated gold nanoparticles eventually are able to cross placenta and whether nanoparticles affect placental functions needs to be further studied.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.reprotox.2008.06.008

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 26

  1. Liu, 2006, Nanoparticles and their biological and environmental applications, J Biosci Bioeng, 1, 1, 10.1263/jbb.102.1 · DOI
  2. Thomas, 2005, Research strategies for safety evaluation of nanomaterials. Part I: evaluating the human health implications of exposure to nanoscale materials, Toxicol Sci, 87, 316, 10.1093/toxsci/kfi270 · DOI
  3. Renwick, 2004, Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types, Occup Environ Med, 61, 442, 10.1136/oem.2003.008227 · DOI
  4. Barlow, 2005, Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration, Toxicol Lett, 155, 397, 10.1016/j.toxlet.2004.11.006 · DOI
  5. Chen, 2005, Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles, Exp Cell Res, 305, 51, 10.1016/j.yexcr.2004.12.021 · DOI
  6. Ala-Kokko, 2000, Ex vivo perfusion of human placental cotyledon. Implications for anesthetic pharmacology, Int J Obstet Anesth, 9, 26, 10.1054/ijoa.1999.0312 · DOI
  7. Hayat, 1989, vol. 1
  8. Panigel, 1962, Placental perfusion experiments, Am J Obstet Gynecol, 84, 1664, 10.1016/0002-9378(62)90009-1 · DOI
  9. Schneider, 1985, Dual in vitro perfusion of an isolated lobe of human placenta: method and instrumentation, Contrib Gynecol Obstet, 13, 40, 10.1159/000410668 · DOI
  10. Myllynen, 2003, Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo, Eur J Clin Pharmacol, 58, 677, 10.1007/s00228-002-0544-4 · DOI
  11. Heikkilä, 2002, Gene transfer to human placenta ex vivo: a novel application of dual perfusion of human placental cotyledon, Am J Obstet Gynecol, 186, 1046, 10.1067/mob.2002.121724 · DOI
  12. Pienimäki, 1995, Carbamazepine and its metabolites in human perfused placenta and in maternal and cord blood, Epilepsia, 36, 241, 10.1111/j.1528-1157.1995.tb00991.x · DOI
  13. Schneider, 1991, Placental transport function, Reprod Fertil Dev, 3, 345, 10.1071/RD9910345 · DOI
  14. Leach, 2002, The phenotype of the human materno-fetal endothelial barrier: molecular occupancy of paracellular junctions dictate permeability and angiogenic plasticity, J Anat, 200, 599, 10.1046/j.1469-7580.2002.00062.x · DOI
  15. Kertschanska, 1997, Pressure dependence of so-called transtrophoblastic channels during fetal perfusion of human placental villi, Microsc Res Tech, 38, 52, 10.1002/(SICI)1097-0029(19970701/15)38:1/2<52::AID-JEMT7>3.0.CO;2-W · DOI
  16. Leach, 1997, Structure and permeability of human placental microvasculature, Microsc Res Tech, 38, 137, 10.1002/(SICI)1097-0029(19970701/15)38:1/2<137::AID-JEMT14>3.0.CO;2-Q · DOI
  17. Desoye, 1997, Location of insulin receptors in the placenta and its progenitor tissues, Microsc Res Tech, 38, 63, 10.1002/(SICI)1097-0029(19970701/15)38:1/2<63::AID-JEMT8>3.0.CO;2-V · DOI
  18. Moestrup, 1996, Megalin-mediated endocytosis of transcobalamin–vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis, Proc Natl Acad Sci USA, 93, 8612, 10.1073/pnas.93.16.8612 · DOI
  19. Malek, 1995, Transport of immunoglobulin G and its subclasses across the in vitro-perfused human placenta, Am J Obstet Gynecol, 173, 760, 10.1016/0002-9378(95)90336-4 · DOI · Paper page
  20. Kaul, 2005, Cellular interactions and in vitro DNA transfection studies with poly(ethylene glycol)-modified gelatin nanoparticles, J Pharm Sci, 94, 184, 10.1002/jps.20216 · DOI
  21. Yang, 2005, Transferrin-mediated gold nanoparticle cellular uptake, Bioconjug Chem, 6, 494, 10.1021/bc049775d · DOI
  22. Brayner, 2006, Toxicological impact studies based on Escherichia coli bacteria in ultrafine ZnO nanoparticles colloidal medium, Nano Lett, 6, 866, 10.1021/nl052326h · DOI
  23. Kawano, 2006, Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses, J Control Release, 111, 382, 10.1016/j.jconrel.2005.12.022 · DOI
  24. Nemmar, 2001, Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster, Am J Respir Crit Care Med, 164, 1665, 10.1164/ajrccm.164.9.2101036 · DOI
  25. Mills, 2006, Do inhaled carbon nanoparticles translocate directly into the circulation in humans?, Am J Respir Crit Care Med, 173, 426, 10.1164/rccm.200506-865OC · DOI
  26. Oyewumi, 2004, Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice, J Control Release, 95, 613, 10.1016/j.jconrel.2004.01.002 · DOI

Cited by

Sorted by citations

Metadata

Authors
Myllynen, P. K., Loughran, M. J., Howard, C. V., Sormunen, R., Walsh, A. A., & Vähäkangas, K. H.
Venue
Reproductive Toxicology
Publisher
Elsevier BV
Published
2008-10
Volume
26
Issue
2
Pages
130-137
ISSN
0890-6238
DOI
10.1016/j.reprotox.2008.06.008
Cited by
158
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review