Nanoparticle Transport Across the Placental Barrier: Pushing the Field Forward!
Open accessAbstract
The human placenta is a multifunctional organ constituting the barrier between maternal and fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence that the extent of transfer is dependent on particle characteristics and functionalization. While translocated particles may pose risks to the growing fetus particles may also be engineered to enable new particle-based therapies in pregnancy. In both cases, a comprehensive understanding of nanoparticle uptake, accumulation and translocation is indispensable and requires predictive placental transfer models. We examine and evaluate the current literature to draw first conclusions on the possibility to steer translocation of nanoparticles. In addition, we discuss if current placental models are suitable for nanoparticle transfer studies and suggest strategies to improve their predictability.
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Evidence from in vivo animal exposure models, ex vivo human placental models, and human placentae demonstrates transport of ultrafine particles across the placental barrier, indicating possible direct effects on placental function and offspring health.
“Evidence from in vivo animal exposure models, ex vivo human placental models, and recent direct evidence from human placentae demonstrate transport of ultrafine particles (UFPs) across the placental barrier indicating possible direct effects on placental function and offspring health [133, 134].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [133]
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Cites
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,887 · see citing works
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037 · see citing works
Biomolecular coronas provide the biological identity of nanosized materials
Monopoli, M. P., Åberg, C., Salvati, A., & Dawson, K. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.207 · Cited by 3,017 · see citing works
Protein−Nanoparticle Interactions: Opportunities and Challenges
Mahmoudi, M., Lynch, I., Ejtehadi, M. R., Monopoli, M. P., Bombelli, F. B., & Laurent, S. (2011) · Chemical Reviews · doi:10.1021/cr100440g · Cited by 1,425 · see citing works
Thalidomide-induced Teratogenesis: History and Mechanisms
Vargesson, N. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21096 · Cited by 912 · see citing works
Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Yamashita, K., Yoshioka, Y., Higashisaka, K., Mimura, K., Morishita, Y., Nozaki, M., Yoshida, T., Ogura, T., Nabeshi, H., Nagano, K., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.41 · Cited by 739 · see citing works
Prospects and Challenges of Graphene in Biomedical Applications
Bitounis, D., Ali‐Boucetta, H., Hong, B. H., Min, D., & Kostarelos, K. (2013) · Advanced Materials · doi:10.1002/adma.201203700 · Cited by 668 · see citing works
Rapid translocation of nanoparticles from the lung airspaces to the body
Choi, H. S., Ashitate, Y., Lee, J. H., Kim, S. H., Matsui, A., Insin, N., Bawendi, M. G., Semmler‐Behnke, M., Frangioni, J. V., & Tsuda, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1696 · Cited by 651 · see citing works
Niikura, K., Matsunaga, T., Suzuki, T., Kobayashi, S., Yamaguchi, H., Orba, Y., Kawaguchi, A., Hasegawa, H., Kajino, K., Ninomiya, T., et al. (2013) · ACS Nano · doi:10.1021/nn3057005 · Cited by 639 · see citing works
Barrier Capacity of Human Placenta for Nanosized Materials
Wick, P., Malek, A., Manser, P., Meili, D., Maeder-Althaus, X., Diener, L., Diener, P., Zisch, A., Krug, H., & von Mandach, U. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901200 · Cited by 599 · see citing works
Self-citationNanopharmaceuticals (part 1): products on the market
Weissig, V., Pettinger, T. K., & Murdock, N. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s46900 · Cited by 591 · see citing works
Nanotoxicology: An Interdisciplinary Challenge
Krug, H. F., & Wick, P. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201001037 · Cited by 556 · see citing works
Self-citationNanoparticles in Biological Systems
Stark, W. J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.200906684 · Cited by 535 · see citing works
Classification Framework for Graphene‐Based Materials
Wick, P., Louw‐Gaume, A. E., Kucki, M., Krug, H. F., Kostarelos, K., Fadeel, B., Dawson, K. A., Salvati, A. L., Vázquez, E., Ballerini, L., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403335 · Cited by 472 · see citing works
Self-citationNanoparticle Size Detection Limits by Single Particle ICP-MS for 40 Elements
Lee, S., Bi, X., Reed, R. B., Ranville, J. F., Herckès, P., & Westerhoff, P. K. (2014) · Environmental Science & Technology · doi:10.1021/es502422v · Cited by 451 · see citing works
Jiang, Y. Y., Huo, S., Mizuhara, T., Das, R., Lee, Y.-W., Hou, S., Moyano, D. F., Duncan, B., Liang, X., & Rotello, V. M. (2015) · ACS Nano · doi:10.1021/acsnano.5b03521 · Cited by 402 · see citing works
Takeda, K., Suzuki, K., Ishihara, A., Kubo‐Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, Y., Ihara, T., & Sugamata, M. (2009) · Eisei kagaku · doi:10.1248/jhs.55.95 · Cited by 381 · see citing works
Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake
Gustafson, H. H., Schneider‐Daum, N., Jones, A. T., Huwer, H., Ghandehari, H., & Lehr, C. (2013) · ACS Nano · doi:10.1021/nn304439f · Cited by 327 · see citing works
Exploring the Interface of Graphene and Biology
Kostarelos, K., & Novoselov, K. S. (2014) · Science · doi:10.1126/science.1246736 · Cited by 319 · see citing works
Brun, É., Barreau, F., Veronesi, G., Barbara Fayard, C., Sorieul, S., Chanéac, C., Carapito, C., Rabilloud, T., Mabondzo, A. M., Herlin‐Boime, N., et al. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-13 · Cited by 299 · see citing works
Microscale tissue engineering using gravity-enforced cell assembly
Kelm, J. M., & Fussenegger, M. (2004) · Trends in biotechnology · doi:10.1016/j.tibtech.2004.02.002 · Cited by 296 · see citing works
Prescription drug use during pregnancy in developed countries: a systematic review
Daw, J. R., Hanley, G. E., Greyson, D. L., & Morgan, S. G. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2184 · Cited by 275 · see citing works
Placenta-on-a-chip: a novel platform to study the biology of the human placenta
Lee, J. S., Romero, R. J., Han, Y. M., Kim, H. C., Kim, C. J., Hong, J., & Huh, D. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1038518 · Cited by 272 · see citing works
Walczak, A. P., Kramer, E., Hendriksen, P. J. M., Tromp, P., Helsper, J. P. F. G., van der Zande, M., Rietjens, I. M. C. M., & Bouwmeester, H. (2014) · Nanotoxicology · doi:10.3109/17435390.2014.944599 · Cited by 238 · see citing works
Hougaard, K. S., Jackson, P., Jensen, K. A., Sloth, J. J., Loeschner, K., Larsen, E. H., Birkedal, R. K., Vibenholt, A., Boisen, A. M. Z., Wallin, H., et al. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-16 · Cited by 238 · see citing works
Pietroiusti, A., Massimiani, M., Fenoglio, I., Colonna, M., Valentini, F., Palleschi, G., Camaioni, A., Magrini, A., Siracusa, G., Bergamaschi, A., et al. (2011) · ACS Nano · doi:10.1021/nn200372g · Cited by 232 · see citing works
Comparative placental structure
Enders, A. C., & Blankenship, T. N. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00003-4 · Cited by 231 · see citing works
Prouillac, C., & Lecoeur, S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033571 · Cited by 214 · see citing works
Hutson, J. R., Garcia-Bournissen, F., Davis, A., & Koren, G. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.66 · Cited by 199 · cited 2× · see citing works
“Recent reviews comprehensively summarized the existing models and approaches to study the translocation and biological effects of xenobiotics at the human placenta [5, 6, 63-66].”
Grafmueller, S., Manser, P., Diener, L., Diener, P., Maeder-Althaus, X., Maurizi, L., Jochum, W., Krug, H., Buerki-Thurnherr, T., von Mandach, U., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409271 · Cited by 190 · see citing works
Self-citationA perspective on the developmental toxicity of inhaled nanoparticles
Hougaard, K. S., Campagnolo, L., Chavatte‐Palmer, P., Couturier‐Tarrade, A., Rousseau‐Ralliard, D., Valentino, S., Park, M. V. D. Z., de Jong, W. H., Wolterink, G., Piersma, A. H., et al. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.05.015 · Cited by 188 · see citing works
Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6
Miura, S., Sato, K., Kato‐Negishi, M., Teshima, T., & Takeuchi, S. (2015) · Nature Communications · doi:10.1038/ncomms9871 · Cited by 185 · see citing works
Effect of particle agglomeration in nanotoxicology
Bruinink, A., Wang, J., & Wick, P. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1460-6 · Cited by 183 · see citing works
Self-citationKinetics of gold nanoparticles in the human placenta
Myllynen, P. K., Loughran, M. J., Howard, C. V., Sormunen, R. T., Walsh, A. A., & Vähäkangas, K. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.06.008 · Cited by 177 · see citing works
Interactions of Engineered Nanoparticles with Organs Protected by Internal Biological Barriers
Pietroiusti, A., Campagnolo, L., & Fadeel, B. (2012) · Small · doi:10.1002/smll.201201463 · Cited by 172 · see citing works
Transfer of Quantum Dots from Pregnant Mice to Pups Across the Placental Barrier
Chu, M., Wu, Q., Yang, H. Y., Yuan, R., Hou, S., Yang, Y., Zou, Y., Xu, S. Q., Xu, K., Ji, A., et al. (2010) · Small · doi:10.1002/smll.200902049 · Cited by 170 · see citing works
Review: Transport across the placenta of mice and women
Dilworth, M. R., & Sibley, C. P. (2013) · Placenta · doi:10.1016/j.placenta.2012.10.011 · Cited by 155 · see citing works
Semmler‐Behnke, M., Lipka, J., Wenk, A., Hirn, S., Schäffler, M., Tian, F., Schmid, G., Oberdörster, G., & Kreyling, W. G. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0033-9 · Cited by 154 · see citing works
Blum, J. L., Xiong, J. Q., Hoffman, C. A., & Zelikoff, J. T. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs008 · Cited by 151 · see citing works
Poulsen, M. S., Rytting, E., Mose, T., & Knudsen, L. E. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.07.028 · Cited by 151 · see citing works
Placental transporters relevant to drug distribution across the maternal-fetal interface.
Ganapathy, V., Prasad, P., Ganapathy, M. E., & Leibach, F. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39087-1 · Cited by 144 · see citing works
Progress and future of in vitro models to study translocation of nanoparticles
Braakhuis, H., Kloet, S. K., Kežić, S., Kuper, C. F., Park, M. V. D. Z., Bellmann, S., van der Zande, M., Gac, S. L., Krystek, P., Peters, R., et al. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1518-5 · Cited by 141 · see citing works
Yang, H. Y., Sun, C., Fan, Z., Tian, X., Yan, L., Du, L., Liu, Y., Chen, C., Liang, X., Anderson, G. J., et al. (2012) · Scientific Reports · doi:10.1038/srep00847 · Cited by 141 · see citing works
Biodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice
Campagnolo, L., Massimiani, M., Palmieri, G., Bernardini, R., Sacchetti, C., Bergamaschi, A., Vecchione, L., Magrini, A., Bottini, M., & Pietroiusti, A. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-21 · Cited by 123 · see citing works
In vitro placental model optimization for nanoparticle transport studies
Rytting, E., Cartwright, Poulsen, Nielsen, Pojana, Knudsen, L. E., & Saunders, M. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s26601 · Cited by 122 · see citing works
Quality assessment of a placental perfusion protocol
Mathiesen, L., Mose, T., Mørck, T. J., Nielsen, J. K. S., Nielsen, L. K., Maroun, L. L., Dziegiel, M. H., Larsen, L. G., & Knudsen, L. E. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.01.006 · Cited by 119 · see citing works
Distribution of silver nanoparticles in pregnant mice and developing embryos
Austin, C. A., Umbreit, T. H., Brown, K. M., Barber, D. S., Dair, B. J., Francke‐Carroll, S., Feswick, A., Saint-Louis, M. A., Hikawa, H., Siebein, K. N., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.626539 · Cited by 118 · see citing works
Menjoge, A. R., Rinderknecht, A. L., Navath, R. S., Faridnia, M., Kim, C. J., Romero, R. J., Miller, R. K., & Kannan, R. M. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.023 · Cited by 117 · see citing works
Myllynen, P., & Vähäkangas, K. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.08.027 · Cited by 115 · see citing works
Nanoparticle accumulation and transcytosis in brain endothelial cell layers
Ye, D., Raghnaill, M. N., Bramini, M., Mahon, E., Åberg, C., Salvati, A. L., & Dawson, K. A. (2013) · Nanoscale · doi:10.1039/c3nr02905k · Cited by 114 · see citing works
Nanoparticles can cross mouse placenta and induce trophoblast apoptosis
Huang, J., Hsieh, P. C. H., Chen, C., Wang, T., Chen, P., Liu, C.-C., Chen, C.-C., & Chen, C. (2015) · Placenta · doi:10.1016/j.placenta.2015.10.007 · Cited by 113 · see citing works
Nanopharmaceuticals (part 2): products in the pipeline
Weissig, V., & Guzman‐Villanueva, D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s65526 · Cited by 110 · see citing works
Fadeel, B., Feliu, N., Vogt, C., Abdelmonem, A. M., & Parak, W. J. (2013) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1206 · Cited by 110 · see citing works
Philbrook, N. A., Walker, V. K., Afrooz, A. R. M. N., Saleh, N. B., & Winn, L. M. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.09.002 · Cited by 106 · see citing works
Bona, K. R. D., Xu, Y., Ramirez, P. A., DeLaine, J., Parker, C., Bao, Y., & Rasco, J. F. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.09.010 · Cited by 104 · see citing works
Ali, H., Kalashnikova, I. V., White, M. A., Sherman, M. B., & Rytting, E. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.010 · Cited by 103 · see citing works
Sumner, S., Fennell, T. R., Snyder, R. W., Taylor, G. F., & Lewin, A. H. (2010) · Journal of Applied Toxicology · doi:10.1002/jat.1503 · Cited by 100 · see citing works
Li, H., van Ravenzwaay, B., Rietjens, I. M. C. M., & Louisse, J. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1074-9 · Cited by 99 · see citing works
Nanomedicine Delivery: does Protein Corona Route to the Target or off Road?
Maiolo, D., del Pino, P., Metrangolo, P., Parak, W. J., & Bombelli, F. B. (2015) · Nanomedicine · doi:10.2217/nnm.15.163 · Cited by 98 · see citing works
Therapeutic and Safety Considerations of Nanoparticle-Mediated Drug Delivery in Pregnancy
Keelan, J. A., Leong, J. W., Ho, D., & Iyer, K. S. (2015) · Nanomedicine · doi:10.2217/nnm.15.48 · Cited by 97 · see citing works
Damaging Effects of Multi-walled Carbon Nanotubes on Pregnant Mice with Different Pregnancy Times
Qi, W., Bi, J., Zhang, X., Wang, J., Wang, J., Liu, P., Li, Z., & Wu, W. (2014) · Scientific Reports · doi:10.1038/srep04352 · Cited by 92 · see citing works
Su, G., Zhou, H., Mu, Q., Zhang, Y., Li, L., Jiao, P., Jiang, G., & Yan, B. (2012) · The Journal of Physical Chemistry C · doi:10.1021/jp211041m · Cited by 91 · see citing works
Kinetics of silica nanoparticles in the human placenta
Poulsen, M. S., Mose, T., Maroun, L. L., Mathiesen, L., Knudsen, L. E., & Rytting, E. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.812259 · Cited by 89 · see citing works
Kloet, S. K., Walczak, A. P., Louisse, J., van den Berg, H. H. J., Bouwmeester, H., Tromp, P., Fokkink, R. G., & Rietjens, I. M. C. M. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.07.003 · Cited by 82 · see citing works
Active transport across the human placenta: impact on drug efficacy and toxicity
Evseenko, D. A., Paxton, J. W., & Keelan, J. A. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.1.51 · Cited by 80 · see citing works
The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development
Huang, X., Zhang, F., Sun, X., Choi, K. Y., Niu, G., Zhang, G., Guo, J., Lee, S., & Chen, X. S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.027 · Cited by 79 · see citing works
Ex vivo perfusion of the human placental cotyledon: implications for anesthetic pharmacology
Ala-Kokko, T. I., Myllynen, P. K., & Vähäkangas, K. (2000) · International Journal of Obstetric Anesthesia · doi:10.1054/ijoa.1999.0312 · Cited by 74 · see citing works
Rattanapinyopituk, K., Shimada, A., MORITA, T., Sakurai, M., ASANO, A., Hasegawa, T., Inoue, K., & Takano, H. (2013) · Journal of Veterinary Medical Science · doi:10.1292/jvms.13-0512 · Cited by 73 · see citing works
Carreira, S. C., Walker, L. A., Paul, K. B., & Saunders, M. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.833317 · Cited by 68 · see citing works
Assessment of an in vitro model of pulmonary barrier to study the translocation of nanoparticles
Dekali, S., Gamez, C., Kortulewski, T., Blazy, K., Rat, P., & Lacroix, G. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.03.003 · Cited by 66 · see citing works
Prescribing without evidence – pregnancy
Thomas, S., & Yates, L. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04332.x · Cited by 59 · see citing works
Knocking at the door of the unborn child: engineered nanoparticles at the human placental barrier
Buerki‐Thurnherr, T., von Mandach, U., & Wick, P. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13559 · Cited by 59 · see citing works
Self-citationGrafmüller, S., Manser, P., Krug, H. F., Wick, P., & von Mandach, U. (2013) · Journal of Visualized Experiments · doi:10.3791/50401 · Cited by 57 · see citing works
Self-citationThe impact of cocaine and heroin on the placental transfer of methadone
Malek, A., Obrist, C., Wenzinger, S., & von Mandach, U. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-61 · Cited by 55 · see citing works
Size of the nanovectors determines the transplacental passage in pregnancy: study in rats
Refuerzo, J., Godin, B., Bishop, K. D., Srinivasan, S., Shah, S. K., Amra, S., Ramin, S. M., & Mauro Ferrari, B. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.02.033 · Cited by 55 · see citing works
Grafmüller, S., Manser, P., Diener, L., Maurizi, L., Diener, P., Hofmann, H., Jochum, W., Krug, H. F., Buerki‐Thurnherr, T., von Mandach, U., et al. (2015) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/16/4/044602 · Cited by 51 · see citing works
Self-citationGeorge, I., Vranic, S., Boland, S., Courtois, A., & Baeza‐Squiban, A. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.08.003 · Cited by 51 · see citing works
Panigel, M., Pascaud, M., & Jl, B. (1967) · PubMed · Cited by 48 · see citing works
In vitro simulation of placental transport: Part I. Biological model of the placental barrier
Levkovitz, R., Zaretsky, U., Gordon, Z., Jaffa, A. J., & Elad, D. (2013) · Placenta · doi:10.1016/j.placenta.2013.03.014 · Cited by 47 · see citing works
Girardi, G., Fraser, J. A., Lennen, R. J., Vontell, R., Jansen, M. A., & Hutchison, G. R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.110 · Cited by 38 · see citing works
Modelling of Human Transplacental Transport as Performed in Copenhagen, Denmark
Mathiesen, L., Mørck, T. A., Zuri, G., Andersen, M. H., Pehrson, C., Frederiksen, M., Mose, T., Rytting, E., Poulsen, M. S., Nielsen, J. K., et al. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12228 · Cited by 31 · see citing works
Juch, H., Nikitina, L., Debbage, P. L., Dohr, G., & Gauster, M. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.05.011 · Cited by 29 · see citing works
The future of nanomedicine: Promises and limitations
Juliano, R. L. (2012) · Science and Public Policy · doi:10.3152/030234212x13214603531969 · Cited by 28 · see citing works
Systems Biology in Nanosafety Research
Fadeel, B. (2015) · Nanomedicine · doi:10.2217/nnm.15.17 · Cited by 10 · see citing works
Centre Suisse d'Electronique et de Microtechnique (CSEM)
Porter, M. E., Emmons, W. M., & Fenner, C. (2003) · Cited by 7 · see citing works
Exploring the interactions of nanoparticles with multiple models of the maternal--fetal interface
Rytting, E. (2015) · Nanotoxicology · doi:10.3109/17435390.2013.877997 · Cited by 4 · see citing works
Nanomaterials and ceramic nanoparticles - use without side-effects?
Roesslein, M., Richter, V., Wick, P. (., & Krug, H. F. (2013) · DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) · doi:10.4416/jcst2012-00038 · Cited by 2 · see citing works
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Ambient black carbon particles reach the fetal side of human placenta
Bové, H., Bongaerts, E., Slenders, E., Bijnens, E. M., Saenen, N. D., Gyselaers, W., Van Eyken, P., Plusquin, M., Roeffaers, M. B. J., Ameloot, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11654-3 · Cited by 709 · see citing works
Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment
Fadeel, B., Bussy, C., Merino, S., Vázquez, E., Emmanuel Flahaut, B., Mouchet, F., Evariste, L., Gauthier, L., Koivisto, A. J., Vogel, U. B., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b04758 · Cited by 678 · see citing works
Self-citationJohnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
Saenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267 · see citing works
Potential adverse effects of nanoparticles on the reproductive system
Wang, R., Song, B., Wu, J., Zhang, Y., Chen, A., & Shao, L. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s170723 · Cited by 253 · see citing works
Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus
Campagnolo, L., Massimiani, M., Vecchione, L., Piccirilli, D., Toschi, N., Magrini, A., Bonanno, E., Scimeca, M., Castagnozzi, L., Buonanno, G., et al. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1343875 · Cited by 147 · see citing works
Tang, J., Bu, W., Hu, W., Zhao, Z., Liu, L., Luo, C., Wang, R., Fan, S., Yu, S., Wu, Q., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c09729 · Cited by 144 · see citing works
Toxicity of airborne particles—established evidence, knowledge gaps and emerging areas of importance
Kelly, F. J., & Fussell, J. C. (2020) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2019.0322 · Cited by 128 · see citing works
A Children’s Health Perspective on Nano- and Microplastics
Sripada, K., Wierzbicka, A., Abass, K., Grimalt, J. O., Erbe, A., Röllin, H. B., Weihe, P., Díaz, G. J., Singh, R. R., Visnes, T., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp9086 · Cited by 143 · see citing works
An advanced human in vitro co-culture model for translocation studies across the placental barrier
Aengenheister, L., Keevend, K., Muoth, C., Schönenberger, R., Diener, L., Wick, P., & Buerki‐Thurnherr, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-23410-6 · Cited by 121 · see citing works
Self-citationPlacenta-specific drug delivery by trophoblast-targeted nanoparticles in mice
Zhang, B., Tan, L., Yu, Y., Wang, B., Chen, Z., Han, J., Li, M., Chen, J., Xiao, T., Ambati, B. K., et al. (2018) · Theranostics · doi:10.7150/thno.22904 · Cited by 120 · see citing works
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials
Dugershaw, B. B., Aengenheister, L., Hansen, S. S. K., Hougaard, K. S., & Buerki‐Thurnherr, T. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00359-x · Cited by 114 · see citing works
Self-citationHou, C.-C., & Zhu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.19087 · Cited by 111 · see citing works
Plasma proteins facilitates placental transfer of polystyrene particles
Gruber, M., Hirschmugl, B., Berger, N., Holter, M., Radulović, S., Leitinger, G., Liesinger, L., Berghold, A., Roblegg, E., Birner‐Gruenberger, R., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00676-5 · Cited by 111 · see citing works
A critical review of assays for hazardous components of air pollution
Forman, H. J., & Finch, C. E. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.030 · Cited by 108 · see citing works
Cureton, N., Korotkova, I., Baker, B., Greenwood, S. L., Wareing, M., Kotamraju, V. R., Teesalu, T., Cellesi, F., Tirelli, N., Ruoslahti, E. I., et al. (2017) · Theranostics · doi:10.7150/thno.19678 · Cited by 102 · see citing works
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
Pritchard, N., Kaitu’u‐Lino, T. J., Harris, L. K., Tong, S., & Hannan, N. J. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa049 · Cited by 101 · see citing works
Toxicity of airborne nanoparticles: Facts and challenges
Portugal, J., Bedia, C., Amato, F., Juárez-Facio, A. T., Stamatiou, R., Lazou, A., Campiglio, C. E., Elihn, K., & Piña, B. (2024) · Environment International · doi:10.1016/j.envint.2024.108889 · Cited by 93 · see citing works
Umezawa, M., Onoda, A., Korshunova, I., Jensen, A. C. Ø., Koponen, I. K., Jensen, K. A., Khodosevich, K., Vogel, U. B., & Hougaard, K. S. (2018) · Particle and Fibre Toxicology · doi:10.1186/s12989-018-0272-2 · Cited by 86 · see citing works
Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta
Warth, B., Preindl, K., Manser, P., Wick, P., Marko, D., & Buerki‐Thurnherr, T. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4860 · Cited by 79 · see citing works
Self-citationA 3D co-culture microtissue model of the human placenta for nanotoxicity assessment
Muoth, C., Wichser, A., Monopoli, M. P., Correia, M., Ehrlich, N., Loeschner, K., Gallud, A., Kucki, M., Diener, L., Manser, P., et al. (2016) · Nanoscale · doi:10.1039/c6nr06749b · Cited by 76 · see citing works
Self-citationAir pollution and neurological development in children
Ha, S. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14758 · Cited by 75 · see citing works
Gold nanoparticle distribution in advanced in vitro and ex vivo human placental barrier models
Aengenheister, L., Dietrich, D., Sadeghpour, A., Manser, P., Diener, L., Wichser, A., Kärst, U., Wick, P., & Buerki‐Thurnherr, T. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0406-6 · Cited by 71 · see citing works
Self-citationVidmar, J., Loeschner, K., Correia, M., Larsen, E. H., Manser, P., Wichser, A., Boodhia, K., Al-Ahmady, Z. S., Ruiz, J., Astruc, D., et al. (2018) · Nanoscale · doi:10.1039/c8nr02096e · Cited by 68 · see citing works
Self-citationChandrasekar, V., Singh, A. V., Maharjan, R. S., Dakua, S. P., Balakrishnan, S., Dash, S., Laux, P., Luch, A., Singh, S., & Pradhan, M. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200010 · Cited by 67 · see citing works
Zhang, B., Liang, R., Zheng, M., Cai, L., & Fan, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153642 · Cited by 65 · see citing works
Nymark, P. E. H., Bakker, M. I., Dekkers, S., Franken, R., Fransman, W., García‐Bilbao, A., Greco, D., Gulumian, M., Hadrup, N., Halappanavar, S. S., et al. (2020) · Small · doi:10.1002/smll.201904749 · Cited by 66 · see citing works
Zhang, Q., Ding, Y., He, K., Li, H., Gao, F., Moehling, T. J., Wu, X., Duncan, J. W., & Niu, Q. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00253 · Cited by 64 · see citing works
Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy
Figueroa‐Espada, C. G., Hofbauer, S. I., Mitchell, M. J., & Riley, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.09.006 · Cited by 63 · see citing works
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review
Krausová, M., Braun, D., Buerki-Thurnherr, T., Gundacker, C., Schernhammer, E., Wisgrill, L., & Warth, B. (2023) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051922-113350 · Cited by 61 · see citing works
Self-citationPotential toxicity of nanoparticles on the reproductive system animal models: A review
Ajdary, M., Keyhanfar, F., Moosavi, M. A., Shabani, R., Mehdizadeh, M., & Varma, R. S. (2021) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2021.103384 · Cited by 64 · see citing works
Research on nanoparticles in human perfused placenta: State of the art and perspectives
Aengenheister, L., Fávaro, R. R., Prieto, D. M. M., Furer, L. A., Gruber, M., Wadsack, C., Markert, U. R., & Buerki‐Thurnherr, T. (2020) · Placenta · doi:10.1016/j.placenta.2020.12.014 · Cited by 57 · see citing works
Self-citationTrophoblast-Targeted Nanomedicine Modulates Placental sFLT1 for Preeclampsia Treatment
Li, L., Yang, H., Chen, P., Xin, T., Zhou, Q., Wei, D., Zhang, Y., & Wang, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00064 · Cited by 54 · see citing works
Buzea, C., & Pacheco, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102641-0.00028-1 · Cited by 54 · see citing works
Fetotoxicity of Nanoparticles: Causes and Mechanisms
Teng, C., Jiang, C., Gao, S., Liu, X., & Zhai, S. (2021) · Nanomaterials · doi:10.3390/nano11030791 · Cited by 51 · see citing works
Su, J., Duan, X., Qiu, Y., Zhou, L., Zhang, H., Gao, M., Liu, Y., Zou, Z., Qiu, J., & Chen, C. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00967-5 · Cited by 51 · see citing works
Aengenheister, L., Dugershaw, B. B., Manser, P., Wichser, A., Schoenenberger, R., Wick, P., Hesler, M., Kohl, Y., Straskraba, S., Suter, M. J. ‐., et al. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.07.018 · Cited by 50 · see citing works
Self-citationVidmar, J., Buerki‐Thurnherr, T., & Loeschner, K. (2018) · Journal of Analytical Atomic Spectrometry · doi:10.1039/c7ja00402h · Cited by 49 · see citing works
Self-citationMuoth, C., Großgarten, M., Kärst, U., Ruiz, J., Astruc, D., Moya, S. E., Diener, L., Grieder, K., Wichser, A., Jochum, W., et al. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0428 · Cited by 46 · see citing works
Self-citationEnvironmental Nanoparticles Reach Human Fetal Brains
Calderón‐Garcidueñas, L., Pérez-Calatayud, Á. A., González-Maciel, A., Reynoso-Robles, R., Silva-Pereyra, H. G., Ramos-Morales, A., Torres‐Jardón, R., Soberanes-Cerino, C. D. J., Carrillo-Esper, R., Briones‐Garduño, J. C., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10020410 · Cited by 43 · see citing works
Nanoparticle Uptake by Plants: Beneficial or Detrimental?
Pacheco, I., & Buzea, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-76708-6_1 · Cited by 43 · see citing works
Magnetic Nanoparticles Interact and Pass an In Vitro Co-Culture Blood-Placenta Barrier Model
Müller, E. K., Gräfe, C., Wiekhorst, F., Bergemann, C., Weidner, A., Dutz, S., & Clement, J. H. (2018) · Nanomaterials · doi:10.3390/nano8020108 · Cited by 40 · see citing works
The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development
Whigham, C., MacDonald, T. M., Walker, S. P., Hannan, N. J., Tong, S., & Kaitu’u‐Lino, T. J. (2019) · Placenta · doi:10.1016/j.placenta.2019.02.002 · Cited by 40 · see citing works
On the developmental toxicity of silver nanoparticles
Zhang, J., Liu, S., Han, J., Wang, Z., & Zhang, S. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.109611 · Cited by 40 · see citing works
Penetration and translocation of functional inorganic nanomaterials into biological barriers
Cong, Y., Baimanov, D., Zhou, Y., Chen, C., & Wang, L. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114615 · Cited by 40 · see citing works
Silica nanocarriers with user-defined precise diameters by controlled template self-assembly
Ribeiro, T., Rodrigues, A. S., Calderon, S., V, Fidalgo, A. M., Gonçalves, J., André, V., Duarte, M. T., Ferreira, P. J., Farinha, J. P. S., & Baleizão, C. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.11.036 · Cited by 39 · see citing works
Emam, B., Shahsavani, A., Khodagholi, F., Zarandi, S. M., Hopke, P. K., Hadei, M., Behbahani, H., & Yarahmadi, M. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-0336-y · Cited by 39 · see citing works
Shabani, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11620-3 · Cited by 39 · see citing works
Uptake and transport of pullulan acetate nanoparticles in the BeWo b30 placental barrier cell model
Tang, H., Jiang, Z., He, H., Li, X., Hu, H., Zhang, N., Dai, Y., & Zhou, Z. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s161319 · Cited by 36 · see citing works
Abdelkhaliq, A., van der Zande, M., Peters, R., & Bouwmeester, H. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00342-6 · Cited by 34 · see citing works
Developmental Toxicity of Nanomaterials: Need for a Better Understanding of Indirect Effects
Buerki‐Thurnherr, T., Schaepper, K., Aengenheister, L., & Wick, P. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00177 · Cited by 33 · see citing works
Self-citationNanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia
Valéro, L., Alhareth, K., Gil, S., Lecarpentier, É., Tsatsaris, V., Mignet, N., Fournier, T., & Andrieux, K. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.048 · Cited by 32 · see citing works
Pietroiusti, A., Vecchione, L., Malvindi, M. A., Aru, C., Massimiani, M., Camaioni, A., Magrini, A., Bernardini, R., Sabella, S., Pompa, P. P., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.01.026 · Cited by 32 · see citing works
Chen, Z., Geng, Y., Gao, R., Zhong, H., Chen, J., Mu, X., Chen, X., Zhang, Y., Li, F., & He, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01334-8 · Cited by 33 · see citing works
Valéro, L., Alhareth, K., Gil, S., Simasotchi, C., Roques, C., Scherman, D., Mignet, N., Fournier, T., & Andrieux, K. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.07.076 · Cited by 32 · see citing works
Bongaerts, E., Aengenheister, L., Dugershaw, B. B., Manser, P., Roeffaers, M. B. J., Ameloot, M. M., Nawrot, T. S., Bové, H., & Buerki‐Thurnherr, T. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00886-5 · Cited by 30 · see citing works
Self-citationTargeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction
Renshall, L. J., Beards, F., Evangelinos, A., Greenwood, S. L., Brownbill, P., Stevens, A., Sibley, C. P., Aplin, J., Johnstone, E., Teesalu, T., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111778 · Cited by 30 · see citing works
NPs-TiO2 and Lincomycin Coexposure Induces DNA Damage in Cultured Human Amniotic Cells
Mottola, F., Iovine, C., Santonastaso, M., Romeo, M. L., Pacifico, S., Cobellis, L., & Rocco, L. (2019) · Nanomaterials · doi:10.3390/nano9111511 · Cited by 29 · see citing works
On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
Deval, G., Boland, S., Fournier, T., & Ferecatu, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212266 · Cited by 28 · see citing works
Juch, H., Nikitina, L., Reimann, S., Gauster, M., Dohr, G., Obermayer-Pietsch, B. M., Hoch, D., Kornmueller, K., & Haag, R. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1425496 · Cited by 26 · see citing works
Adaptive changes induced by noble-metal nanostructures in vitro and in vivo
Huang, Q., Zhang, J., Zhang, Y., Timashev, P. S., Ma, X., & Liang, X. (2020) · Theranostics · doi:10.7150/thno.42569 · Cited by 26 · see citing works
Zhang, S., Meng, P., Cheng, S., Jiang, X., Zhang, J., Qin, X., Tang, Q., Bai, L., Zou, Z., & Chen, C. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.07.004 · Cited by 25 · see citing works
Fliedel, L., Alhareth, K., Mignet, N., Fournier, T., & Andrieux, K. (2022) · Biomedicines · doi:10.3390/biomedicines10050936 · Cited by 24 · see citing works
El-Ashram, S. A., Kheirallah, D. A. M., El‐Samad, L. M., & Toto, N. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241837 · Cited by 23 · see citing works
An overview on the reproductive toxicity of graphene derivatives: Highlighting the importance
Hadizadeh, N., Zeidi, S., Khodabakhsh, H., Zeidi, S., Rezaei, A., Liang, Z., Dashtizad, M., & Hashemi, E. (2022) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0063 · Cited by 21 · see citing works
Kaur, S., Morales‐Hidalgo, P., Arija, V., & Canals, J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20085443 · Cited by 21 · see citing works
Zhang, Y., Wu, J., Feng, X., Wang, R., Chen, A., & Shao, L. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1397131 · Cited by 21 · see citing works
Costanzo, M., & Malatesta, M. (2019) · European Journal of Histochemistry · doi:10.4081/ejh.2019.3026 · Cited by 21 · see citing works
Pereira, K. V., Giacomeli, R., de Gomes, M. G., & Haas, S. E. (2020) · Placenta · doi:10.1016/j.placenta.2020.08.005 · Cited by 22 · see citing works
Rahman, M. M., Carter, S., Lin, J. C., Chow, T., Yu, X., Martinez, M. P., Levitt, P. R., Chen, Z., Chen, J., Rud, D., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107736 · Cited by 20 · see citing works
Lu, C., Peng, W., Kuang, J., Wu, M., Wu, H., Murithi, R. G., Johnson, M. B., & Zheng, X. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111860 · Cited by 20 · see citing works
Harris, L. K. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0234 · Cited by 20 · see citing works
Gender-specific effects of prenatal polystyrene nanoparticle exposure on offspring lung development
Bu, W., Yu, M., Ma, X., Shen, Z., Ruan, J., Qu, Y., Huang, R., Xue, P., Ma, Y., Tang, J., et al. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.03.001 · Cited by 19 · see citing works
Advance in placenta drug delivery: concern for placenta-originated disease therapy
Tang, M., Zhang, X., Fei, W., Xin, Y., Zhang, M., Yao, Y., Zhao, Y., Zheng, C., & Sun, D. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2184315 · Cited by 19 · see citing works
Naguib, G. H., El-Aziz, G. S. A., Kayal, R. A., Mira, A. I., Hajjaj, M. S., Mously, H. A., & Hamed, M. T. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2258917 · Cited by 19 · see citing works
Drug Delivery During pregnancy: How Can Nanomedicine Be used?
Joshi, M. D. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0084 · Cited by 18 · see citing works
Kucki, M., Aengenheister, L., Diener, L., Rippl, A., Vranic, S., Newman, L., Vázquez, E., Kostarelos, K., Wick, P., & Buerki‐Thurnherr, T. (2018) · 2D Materials · doi:10.1088/2053-1583/aab9e2 · Cited by 18 · see citing works
Self-citationNanotechnologies in Obstetrics and Cancer during Pregnancy: A Narrative Review
Bertozzi, S., Corradetti, B., Seriau, L., Ñañez, J. A. D., Cedolini, C., Fruscalzo, A., Cesselli, D., Cagnacci, A., & Londero, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081324 · Cited by 14 · see citing works
Safety and toxicity concerns of graphene and its composites
Koyyada, A., & Orsu, P. (2020) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2020.08.011 · Cited by 16 · see citing works
Wang, P., Li, G., Shou, H., Huang, X., Xu, H., Zhang, S., & Zhu, H. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105918 · Cited by 14 · see citing works
Active Diffusion of Nanoparticles of Maternal Origin Within the Embryonic Brain
Yuryev, M. V., Ferreira, M. P. A., Balasubramanian, V., Correia, A. M. R., Mäkilä, E. M., Jokinen, V. P., Andriichuk, L., Kemell, M., Salonen, J., Hirvonen, J. J., et al. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0207 · Cited by 14 · see citing works
Belagalla, N., Kumar, A., Badekhan, A., Chaturvedi, K., Kumar, A., Panigrahi, C. K., Sachan, K., & Singh, B. V. (2024) · Journal of Advances in Biology & Biotechnology · doi:10.9734/jabb/2024/v27i5791 · Cited by 13 · see citing works
Lei, M., Zhu, Z., Wei, C., Xie, H., Guo, R., Zhao, Y., Wang, K., Wang, M., Chen, W., Xu, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202410353 · Cited by 12 · see citing works
Tse, W. H., Higgins, S., Patel, D., Xing, M. M. Q., West, A. R., Labouta, H. I., & Keijzer, R. (2022) · Biomaterials Science · doi:10.1039/d2bm00293k · Cited by 13 · see citing works
Qualitative and quantitative analysis of the uptake of lipoplexes by villous placenta explants
Alhareth, K., Valéro, L., Mohamed, K. E., Fliedel, L., Roques, C., Gil, S., Mignet, N., Fournier, T., & Andrieux, K. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118479 · Cited by 11 · see citing works
Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development
Zhang, P., Li, T., Liu, C., Sindi, M., Cheng, X., Qi, S., Liu, X., Yan, Y., Bao, Y., Brand‐Saberi, B., et al. (2020) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2020.151617 · Cited by 11 · see citing works
Jia, M., Jia, X., Zhang, D., Liu, W., Yi, S., Li, Z., Cong, B., Ma, C., Li, S., & Zhang, J. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-980 · Cited by 10 · see citing works
Hamdi, H., & Hassan, M. M. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.05.003 · Cited by 10 · see citing works
Nanotoxicology and Human Health
Sia, P. D. (2018) · World Scientific News · Cited by 10 · see citing works
Güneş, M. S. A., Aktaş, K., Yalçın, B., Burgazlı, A. Y., Asiltürk, M., Ünşar, A. E., & Kaya, B. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104412 · Cited by 9 · see citing works
Estimation of silver nanoparticles effect on the reproductive health of female Wistar rats
Mohamed, Y., El-Ghareeb, A.-W., Attaby, F. A., & El‐Rahman, H. A. A. (2022) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2022.2092821 · Cited by 8 · see citing works
Furer, L. A., Abad, Á. D., Manser, P., Hannig, Y., Schuerle, S., Fortunato, G., & Buerki‐Thurnherr, T. (2022) · Nanoscale · doi:10.1039/d2nr01742c · Cited by 8 · see citing works
Self-citationStuettgen, V., Giffney, H. E., Anandan, A., Alabdali, A., Twarog, C., Belhout, S. A., O′Loughlin, M., Podhorska, L., Delaney, C., Geoghegan, N., et al. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1621402 · Cited by 8 · see citing works
Rduch, T., Arn, N., Kinkel, J., Fischer, T., Binet, I., Hornung, R., & Herrmann, I. K. (2023) · Artificial Organs · doi:10.1111/aor.14531 · Cited by 8 · see citing works
Epigenetic Effects of Air Pollution
Burgio, E., & Ciaula, A. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-62731-1_13 · Cited by 8 · see citing works
Lederer, C. W., Koniali, L., Buerki‐Thurnherr, T., Papasavva, P. L., Grutta, S. L., Licari, A., Štaud, F., Bonifazi, D., & Kleanthous, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040793 · Cited by 8 · see citing works
Self-citationNemati, A., Beyranvand, F., Assadollahi, V., Salahshoor, M. R., Alasvand, M., & Gholami, M. (2020) · Birth Defects Research · doi:10.1002/bdr2.1844 · Cited by 7 · see citing works
Lavezzi, A. M., Pusiol, T., & Paradiso, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074164 · Cited by 7 · see citing works
Fliedel, L., Alhareth, K., Séguin, J., Elkhashab, M., Chissey, A., Mignet, N., Fournier, T., & Andrieux, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116299 · Cited by 7 · see citing works
Wang, Z., Liu, W., Zhang, S., Zhang, J., & Liu, S. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b04581 · Cited by 7 · see citing works
- Authors
- Muoth, C., Aengenheister, L., Kucki, M., Wick, P., & Buerki-Thurnherr, T.
- Affiliations
- Empa (CH)
- Empa–Swiss Federal Laboratories for Materials Science & Technology, St. Gallen, Switzerland
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2016-03-16
- Volume
- 11
- Issue
- 8
- Pages
- 941-957
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2301631169
- Cited by
- 146
- References
- 88
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 6 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 23 · 2019: 13 · 2018: 22 · 2017: 7 · 2016: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.dora.lib4ri.ch
- Licence
- other-oa
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion, other-oa)
- Funders
- Graphene Flagship
- European Commission
- Leibniz-Gemeinschaft
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- nanoparticle transport, placental barrier, nanoparticle functionalization, particle properties, prenatal exposure, prediction model
- MeSH terms
- Animals, Biological Transport, Female, Humans, Placenta, Pregnancy, Nanotechnology, Nanomedicine, Nanoparticles
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