The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Consequences of exercise-induced respiratory muscle work
Abstract
We briefly review the evidence for a hypothesis, which links the ventilatory response to heavy intensity, sustained exercise-to-exercise performance limitation in health. A key step in this linkage is a respiratory muscle fatigue-induced metaboreflex, which increases sympathetic vasoconstrictor outflow, causing reduced blood flow to locomotor muscles and locomotor muscle fatigue. In turn, the limb fatigue comprises an important dual contribution to both peripheral and central fatigue mechanisms, which contribute to limiting exercise performance. Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined.
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“Apical breathing causes reliance on fatiguable accessory muscles of respiration, underutilising the efficient and relatively fatigue-resistant diaphragmatic muscle, further increasing the work of breathing and intensifying breathlessness.”
From The Breathing, Thinking, Functioning clinical model: a proposal to facilitate evidence-based breathlessness management in chronic respiratory disease (2017) · cites this paper as [32]
Citations
Cites
Spinal and Supraspinal Factors in Human Muscle Fatigue
Gandevia, S. C. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1725 · Cited by 3,855
Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076
Respiratory muscle work compromises leg blood flow during maximal exercise
Harms, C. A., Babcock, M. A., McClaran, S. R., Pegelow, D. F., Nickele, G. A., Nelson, W. B., & Dempsey, J. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.5.1573 · Cited by 711
Self-citationExercise‐induced diaphragmatic fatigue in healthy humans.
Johnson, B. D., Babcock, M. A., Suman-Vejas, O. E., & Dempsey, J. A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019477 · Cited by 487
Self-citationProportional Assist Ventilation, a New Approach to Ventilatory Support: Theory
Younes, M. K. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.1.114 · Cited by 483
Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise
Harms, C. A., Wetter, T. J., McClaran, S. R., Pegelow, D. F., Nickele, G. A., Nelson, W. B., Hanson, P., & Dempsey, J. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.2.609 · Cited by 469
Self-citationEffects of respiratory muscle work on exercise performance
Harms, C. A., Wetter, T. J., St. Croix, C. M., Pegelow, D. F., & Dempsey, J. A. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.131 · Cited by 419
Self-citationMechanical constraints on exercise hyperpnea in endurance athletes
Johnson, B. D., Saupe, K. W., & Dempsey, J. A. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.3.874 · Cited by 384
Self-citationOxygen cost of exercise hyperpnea: implications for performance
Aaron, E. A., Seow, K. C., Johnson, B. D., & Dempsey, J. A. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.5.1818 · Cited by 377
Self-citationFatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans
Sheel, A. W., Derchak, P. A., Morgan, B. J., Pegelow, D. F., Jacques, A. J., & Dempsey, J. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0277k.x · Cited by 331
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Research works printed but not linked: 1
- Miller, 2005, Respiratory muscle metaboreflex limits locomotor limb blood flow during submaximal exercise in CHF, FASEB J., 19
Cited by
Sorted by citations
Aquatic Therapy: Scientific Foundations and Clinical Rehabilitation Applications
Becker, B. E. (2009) · PM&R · doi:10.1016/j.pmrj.2009.05.017 · Cited by 675
Ansdell, P., Thomas, K., Hicks, K. M., Hunter, S. K., Howatson, G., & Goodall, S. (2020) · Experimental Physiology · doi:10.1113/ep088548 · Cited by 403
Effect of Respiratory Muscle Training on Exercise Performance in Healthy Individuals
Illi, S. K., Held, U., Frank, I., & Spengler, C. M. (2012) · Sports Medicine · doi:10.1007/bf03262290 · Cited by 367
Exercise-induced respiratory muscle fatigue: implications for performance
Romer, L. M., & Polkey, M. I. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01157.2007 · Cited by 354
Self-citationHøydal, M. A., Wisløff, U., Kemi, O. J., & Ellingsen, Ø. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3281eacef1 · Cited by 352
Metadata
- Authors
- Dempsey, J. A., Romer, L., Rodman, J., Miller, J., & Smith, C.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Dempsey, Jerome A.
- Venue
- Respiratory Physiology & Neurobiology
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 151
- Issue
- 2-3
- Pages
- 242-250
- ISSN
- 1569-9048 (ISSN-L)
- OpenAlex
- W1973218442
- Cited by
- 398
- References
- 35
- Citations by year
- 2026: 23 · 2025: 22 · 2024: 19 · 2023: 18 · 2022: 28 · 2021: 23 · 2020: 34 · 2019: 26 · 2018: 26 · 2017: 22 · 2016: 14 · 2015: 18 · 2014: 14 · 2013: 9 · 2012: 22
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Respiratory Physiology & Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- muscle metaboreflex, ventilatory response, central fatigue, peripheral fatigue, sympathetic vasoconstriction, chronic obstructive pulmonary disease, chronic heart failure, respiratory muscle work
- MeSH terms
- Animals, Humans, Models, Biological, Physical Endurance, Respiratory Muscles, Exercise, Muscle, Skeletal, Muscle Fatigue
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