Cited by 398Cardiovascular and exercise physiologySports Performance and TrainingNeuroscience of respiration and sleep

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Consequences of exercise-induced respiratory muscle work

Dempsey, Jerome A., Romer, Lee, Rodman, Joshua, Miller, Jordan, Smith, Curtis·2006·Respiratory Physiology & Neurobiology

DOI 10.1016/j.resp.2005.12.015

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Abstract

We briefly review the evidence for a hypothesis, which links the ventilatory response to heavy intensity, sustained exercise-to-exercise performance limitation in health. A key step in this linkage is a respiratory muscle fatigue-induced metaboreflex, which increases sympathetic vasoconstrictor outflow, causing reduced blood flow to locomotor muscles and locomotor muscle fatigue. In turn, the limb fatigue comprises an important dual contribution to both peripheral and central fatigue mechanisms, which contribute to limiting exercise performance. Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined.

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Authors: Dempsey, J. A., Romer, L., Rodman, J., Miller, J., & Smith, C.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Dempsey, Jerome A.
ORCID: Dempsey, Jerome A.
Romer, Lee
Miller, Jordan
Smith, Curtis
Venue: Respiratory Physiology & Neurobiology
Publisher: Elsevier BV
Published: 2006-04
Volume: 151
Issue: 2-3
Pages: 242-250
ISSN: 1569-9048 (ISSN-L)
DOI: 10.1016/j.resp.2005.12.015
OpenAlex: W1973218442
Cited by: 398
References: 35
Citations by year: 2026: 23 · 2025: 22 · 2024: 19 · 2023: 18 · 2022: 28 · 2021: 23 · 2020: 34 · 2019: 26 · 2018: 26 · 2017: 22 · 2016: 14 · 2015: 18 · 2014: 14 · 2013: 9 · 2012: 22
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Respiratory Physiology & Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Heart, Lung, and Blood Institute
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: muscle metaboreflex, ventilatory response, central fatigue, peripheral fatigue, sympathetic vasoconstriction, chronic obstructive pulmonary disease, chronic heart failure, respiratory muscle work
MeSH terms: Animals, Humans, Models, Biological, Physical Endurance, Respiratory Muscles, Exercise, Muscle, Skeletal, Muscle Fatigue

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Consequences of exercise-induced respiratory muscle work

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