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Cited by 39Neuroscience of respiration and sleepHeart Rate Variability and Autonomic ControlRespiratory and Cough-Related Research

Learning to breathe: habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.

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Dutschmann, Mathias, Bautista, Tara G., Mörschel, Michael, Dick, Thomas E.·2014·Respiratory Physiology & Neurobiology
DOI 10.1016/j.resp.2014.02.009PMC PMC4111629
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Abstract

The Hering-Breuer (HBR) reflex is considered a major regulatory feedback for the generation and patterning of respiratory activity. While HBR is important in neonates, its significance in adults is controversial. Previous experiments that investigated the plasticity of entrainment of the respiratory rhythm by vagal input demonstrated postnatal changes in HBR plasticity. Here we analyzed postnatal changes in the plasticity of HBR by mimicking the classic lung inflation tests with repetitive tonic vagal stimulation across different postnatal stages in an in situ perfused brainstem preparation of rat. The study shows that neonates stereotypically exhibit HBR stimulus-dependent prolongation of expiration while juvenile preparations (>postnatal day 16) showed significant habituation of HBR following repetitive stimulation. Subsequent experiments employing physiological lung inflation tests in situ confirmed HBR habituation in juveniles. We conclude that postnatal emergence of HBR habituation explains the weak contribution and high activation threshold of HBR in the regulation of eupnea.

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Authors
Dutschmann, M., Bautista, T. G., Mörschel, M., & Dick, T. E.
Affiliations
  • Florey Institute of Neuroscience and Mental Health (AU)
  • Bernstein Center for Computational Neuroscience Göttingen (DE)
  • Case Western Reserve University (US)
Corresponding author
Dutschmann, Mathias
ORCID
Venue
Respiratory Physiology & Neurobiology
Publisher
Elsevier BV
Published
2014-05
Volume
195
Pages
44-49
ISSN
1569-9048 (ISSN-L)
DOI
10.1016/j.resp.2014.02.009
PMC
PMC4111629
OpenAlex
W2094029706
Cited by
39
References
1
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 9 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1
FWCI
1.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Respiratory Physiology & Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R33HL087377)
  • National Institute of Neurological Disorders and Stroke (R01NS069220)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords
Hering-Breuer reflex, habituation, vagus nerve stimulation, neonatal respiratory development, lung inflation, rat brainstem
MeSH terms
Animals, Brain Stem, Electric Stimulation, Lung, Neuronal Plasticity, Phrenic Nerve, Reflex, Respiration, Vagus Nerve, Exhalation, Rats, In Vitro Techniques

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