Surviving out-of-hospital cardiac arrest: the neurological and functional outcome and health-related quality of life one year later
Open accessAbstract
Background Data on long-term functional outcome and quality of life (QoL) after out-of-hospital cardiac arrest (OHCA) are limited. We assessed long-term functional outcome and health-related QoL of OHCA survivors regardless of arrest aetiology. Methods All adult unconscious OHCA patients treated in 21 Finnish ICUs between March 2010 and February 2011 were followed. Barthel Index (BI), activities of daily living (ADL), accommodation, help needed and received, working status, car driving and self-experienced cognitive deficits were assessed in 1-year survivors (N = 206, 40.9% of the original FINNRESUSCI cohort) with a structured telephone interview. Health-related QoL and more complex ADL-functions were evaluated by EQ-5D and instrumental ADL questionnaires. Results Good outcome, defined as Cerebral Performance Categories 1 or 2, had been reached by 90.3% of survivors. The median BI score was 100, and 91.3% of survivors were independent in basic ADL-functions. The great majority of survivors were living at home, only 8.7% lived in a sheltered home or needed institutionalized care. Of home-living survivors 71.4% scored high in instrumental ADL assessment. The majority (72.6%) of survivors who were working previously had returned to work. Health-related QoL was similar as in age- and gender-adjusted Finnish population. Conclusions Long-term functional outcome was good in over 90% of patients surviving OHCA, with health-related quality of life similar to that of an age and gender…
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The EIC model mandates obtaining post-enrolment consent.
“The EIC model also mandates obtaining post-enrolment consent. 317”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [317]
Striking the best balance between respect for autonomy and beneficence or non-maleficence has been recognised as one of the greatest challenges of emergency research conduct.
“Striking the best balance between respect for autonomy (i.e. the right to selfdetermination) and beneficence (i.e. improving patient outcomes) or even non-maleficence (i.e. avoiding patient exposure to unproven treatments) has been recognised as one of the greatest challenges of emergency research conduct. 63,195,317,319”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [317]
Deferred consent may be necessary because the therapeutic window is too narrow to obtain a valid preenrolment consent.
“Deferred consent (i.e. obtaining consent from a surrogate and/or patient as soon as possible after enrolment) may be necessary because the therapeutic window is too narrow to obtain a valid preenrolment consent. 63,317,322 324”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [317]
Regulatory improvements are still needed as the new regulation does not concern clinical trials evaluating devices.
“Nevertheless, regulatory improvements are still needed as the new regulation does not concern clinical trials evaluating devices. 317”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [317]
The new regulation enables potentially beneficial, low-risk, multicentre, and multinational cardiac arrest research.
“Thus, the new regulation enables potentially beneficial, low-risk, multicentre, and multinational cardiac arrest research. 195,317,320”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [317]
Cites
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Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
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Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
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European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions
Mentzelopoulos, S. D., Couper, K., Voorde, P. V. D., Druwé, P., Blom, M., Perkins, G. D., Lulic, I., Djakow, J., Raffay, V., Lilja, G., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.017 · Cited by 246 · see citing works
“Response rates vary markedly across trials.(288,308,309) A key concern is that respondents may be systematically different to non-respondents.”
Background
- Authors
- Tiainen, M., Vaahersalo, J., Skrifvars, M. B., Hästbacka, J., Grönlund, J., & Pettilä, V.
- Affiliations
- Helsinki University Hospital (FI)
- University of Helsinki (FI)
- University of Turku (FI)
- Corresponding author
- Tiainen, Marjaana
- Venue
- Resuscitation
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 129
- Pages
- 19-23
- ISSN
- 0300-9572 (ISSN-L)
- OpenAlex
- W2803385094
- Cited by
- 43
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 1 · 2015: 1
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Resuscitation (publishedVersion)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkléns minne
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Keywords
- out-of-hospital cardiac arrest, long-term functional outcome, health-related quality of life, neurological outcome, activities of daily living, Barthel Index, return to work, living at home, cognitive impairment, driving
- MeSH terms
- Activities of Daily Living, Aged, Cognition, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Surveys and Questionnaires, Time Factors, Cardiopulmonary Resuscitation, Survivors, Recovery of Function, Out-of-Hospital Cardiac Arrest
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