A cryptographic framework for secure medical imaging in smart healthcare environments
Open accessAbstract
• Proposed a hybrid AES-128 and RSA-1024 encryption model for medical image security. • Achieved efficient encryption/decryption times suitable for real-time applications. • Demonstrated strong security metrics including high NPCR and UACI values. • Maintained high image quality post-decryption with favorable PSNR and MSE values. • Validated encryption strength through histogram, correlation, and entropy analyses. In the dynamic environment of innovative healthcare, securing medical images is indispensable because they are commonly sent and stored over digital media. This paper introduces a strong hybrid encryption scheme combining AES-128 (Advanced Encryption Standard) and RSA-1024 (Rivest-Shamir-Adleman) to improve security and the performance of medical image encryption. The new model employs AES-128 to encrypt images speedily and efficiently and RSA-1024 to securely share keys. Experimental verification was performed on a brain MRI dataset of 7023 images of 512 × 512 pixels. Encryption time ranged from 0.5 to 2.9 seconds depending on the AES mode, whereas decryption was significantly faster, from 0.1 to 0.9 seconds. The throughput analysis indicated encryption rates of up to 21.8 Mbps and decryption rates of 22.5 Mbps, with the best performance in CTR and OCB modes. Security was measured with MSE, PSNR, NPCR, UACI, histogram uniformity, correlation analysis, and entropy. PSNR was more than 50 dB in CFB and CBC modes, NPCR was more than 99.5 %, and entropy was close to the…
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In CBC mode, chaining propagates local changes of plaintext pixels in each block to wipe out spatial correlation, and stronger diffusion is measured as NPCR/UACI values.
“in this case, the propagation of the chaining of local changes of plaintext pixels in each block will wipe out the spatial correlation, and the stronger diffusion will be measured in this case as NPCR/UACI values [58,59].”
From A hybrid encryption algorithm based on AES and Kyber for secure image protection in the post-quantum era (2026) · cites this paper as [59]
Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
Qasim, A. F., Meziane, F., & Aspin, R. (2017) · Computer Science Review · doi:10.1016/j.cosrev.2017.11.003 · Cited by 167 · see citing works
2018 International Conference on Communication and Signal Processing (ICCSP)
(2018) · International Conference on Communications and Signal Processing (ICCSP) · doi:10.1109/iccsp.2018.8524396 · Cited by 166 · see citing works
A Review of Medical Image Watermarking Requirements for Teleradiology
Nyeem, H., Boles, W., & Boyd, C. (2012) · Journal of Imaging Informatics in Medicine · doi:10.1007/s10278-012-9527-x · Cited by 159 · see citing works
An efficient image encryption scheme for healthcare applications
Sarosh, P., Parah, S. A., & Bhat, G. M. (2022) · Multimedia Tools and Applications · doi:10.1007/s11042-021-11812-0 · Cited by 93 · see citing works
Image encryption method based on improved ECC and modified AES algorithm
Hafsa, A., Sghaier, A., Malek, J., & Machhout, M. (2021) · Multimedia Tools and Applications · doi:10.1007/s11042-021-10700-x · Cited by 90 · see citing works
Image Steganography Using LSB and Hybrid Encryption Algorithms
Alanzy, M., Alomrani, R., Alqarni, B., & Almutairi, S. M. (2023) · Applied Sciences · doi:10.3390/app132111771 · Cited by 74 · see citing works
A security model to protect the isolation of medical data in the cloud using hybrid cryptography
Gadde, S., Amutharaj, J., & Usha, S. M. (2023) · Journal of Information Security and Applications · doi:10.1016/j.jisa.2022.103412 · Cited by 45 · see citing works
Robust medical and color image cryptosystem using array index and chaotic S-box
Podder, D., Deb, S., Banik, D., Kar, N., & Sahu, A. K. (2024) · Cluster Computing · doi:10.1007/s10586-024-04584-3 · Cited by 33 · see citing works
Medical Image Encryption Based on Hybrid AES with Chaotic Map
Hashim, A. T., Jabbar, A. K., & Hassan, Q. F. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1973/1/012037 · Cited by 20 · see citing works
Hybridization of RSA and AES algorithms for authentication and confidentiality of medical images
J, S. K. B., Nair, A., & Roshni Raj, V. K. (2017) · International Conference on Communications and Signal Processing (ICCSP) · doi:10.1109/iccsp.2017.8286536 · Cited by 19 · see citing works
Wen, W., Yuan, Z., Qi, S., Zhang, Y., & Fang, Y. (2023) · IEEE Transactions on Multimedia · doi:10.1109/tmm.2023.3339588 · Cited by 18 · see citing works
Kumar, P. R., & Goel, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-92245-9 · Cited by 18 · see citing works
Adabala, P. A., Gowtham, R., Thambi, J., Rishisri, V. S., & Kavitha, C. R. (2024) · IEEE Delhi Section Conference (DELCON) · doi:10.1109/delcon64804.2024.10866627 · Cited by 10 · see citing works
Das, A., Das, A., & Kar, N. (2021) · Journal of Ambient Intelligence and Humanized Computing · doi:10.1007/s12652-021-02943-1 · Cited by 9 · see citing works
Belkaid, B. M., Lahdir, M., Mehdi, C., & Ameur, S. (2015) · International Conference on Computer Vision and Image Analysis Applications (ICCVIA) · doi:10.1109/iccvia.2015.7351789 · Cited by 8 · see citing works
Hybrid Encryption Algorithms for 2D Medical Image Security and Anomaly Detection: A Novel Approach
Vidhyambika, S. R., & Rajathi, N. (2025) · International Conference on Computational Innovations and Engineering Sustainability (ICCIES) · doi:10.1109/iccies63851.2025.11033087 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Verma, 2022, Design simulation and analysis for securing medical images using hybrid algorithm, Acta Energ.
- A. M. K. 1 Lakhtaria 2 Dr Kamaljit, “Journal of natural and applied sciences ural - enhancing hybrid system based mixing AES and RSA cryptography algorithms.” Accessed: Apr. 03, 2025. [Online]. Available: https://uraljournal.remahcenter.com/index.php/papers/no3-papers-volume-2/item/298-enhancing-hybrid-system-based-mixing-aes-and-rsa-cryptography-algorithms.
- “Securing cloud data: a hybrid encryption approach with RSA and AES for enhanced security and performance | Journal of integrated science and technology.” Accessed: Apr. 03, 2025. [Online]. Available: https://pubs.thesciencein.org/journal/index.php/jist/article/view/a1060.
- Verma, 2022, Design simulation and analysis for securing medical images using hybrid algorithm, Acta Energ., 42
- “Comparative study on AES and RSA algorithm for medical images, IEEE Conference Publication | IEEE Xplore.” Accessed: Aug. 10, 2025. [Online]. Available: https://ieeexplore.ieee.org/document/8286408.
- 2017, Brain tumor dataset, Figshare
Cited by
Sorted by citations
Thandya, R. P., Ramadhan, I. F., Croix, N. J. D. L., Ahmad, T., Ahmad, R. A., Ginting, D. K., Mamamoba, S. Y., & Uwizeye, D. (2025) · Results in Engineering · doi:10.1016/j.rineng.2025.108915 · Cited by 2 · see citing works
Al-Rufaye, F. M. L., Farhan, A. K., & Hamid, N. (2026) · Array · doi:10.1016/j.array.2026.100850 · Cited by 1 · see citing works
Singh, P., Hasija, T., Ramkumar, K. R., & Kanika (2026) · Discover Computing · doi:10.1007/s10791-026-10577-0
“AES-256 is the DEM as it is a symmetric block cypher that processes bulk image data quickly; it is the NIST-recommended [58, 59].”
Secure Brain MRI Encryption Using RNA Encoding and Substitution-Permutation Network
Rashid, O. F., Subhi, M. A., & Ali, S. M. M. (2025) · Journal of Artificial Intelligence in Medical Applications · doi:10.65511/jaima.v1i1.743
Chu, P., Wu, W., Guan, X., & Yang, Z. (2026) · Physica Scripta · doi:10.1088/1402-4896/ae4838
Dağ, G. N., & Horasan, F. (2026) · Expert Systems with Applications · doi:10.1016/j.eswa.2026.133214
A Robust Visual Cryptography Driven Authentication Framework for Secure Image Transmission
Karunya, A., & Selva Mary, G. (2026) · International Conference on Computational Intelligence and Communication Networks (CICN) · doi:10.1109/cicn70047.2026.11594150
Muley, N., & Kale, N. (2026) · Genetics and Molecular Research · doi:10.4238/npcfdd57
VARStego: A Reversible Local Variance-Based Steganographic Method
Salim, B. A., D’Layla, A. W. C., Croix, N. J. D. L., Ahmad, T., & Mtonga, K. (2026) · Computers, materials & continua/Computers, materials & continua (Print) · doi:10.32604/cmc.2026.085342
Katılmış, Z., & Koç, Ş. (2026) · El-Cezeri Fen ve Mühendislik Dergisi · doi:10.31202/ecjse.1796961
Securing Medical Imaging Systems Against Emerging Cyber Threats: A Multi-faceted Approach
Potlabathini, R., Jamalpur, B., & Khan, N. U. (2026) · International Research Journal of Multidisciplinary Scope · doi:10.47857/irjms.2026.v07i04.011127
Masruroh, S., Tahir, M., & Putri, K. (2026) · Jurnal Ilmiah Sistem Informasi (JISI) · doi:10.24127/jisi.v5i2.11828
Medical data protection: Advanced Bayesian tactical unit framework for encryption and auditing
Shankar, K. M. K., & Santhi, V. (2026) · Information Sciences · doi:10.1016/j.ins.2026.124373
- Authors
- Lata, K., Gupta, C., & Cenkeramaddi, L. R.
- Affiliations
- LNM Institute of Information Technology (IN)
- JK Lakshmipat University (IN)
- University of Agder (NO)
- Corresponding author
- Cenkeramaddi, Linga Reddy
- Venue
- Results in Engineering
- Publisher
- Elsevier BV
- Published
- 2025-09
- Volume
- 27
- Pages
- 106780
- ISSN
- 2590-1230 (ISSN-L)
- OpenAlex
- W4413289902
- Semantic Scholar
- 667bba1fb48d4fe739ee2ba6754b8a02aab5cb33
- Cited by
- 13
- References
- 19
- Citations by year
- 2026: 11 · 2025: 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Results in Engineering (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Chaos-based Image/Signal Encryption
- Physical Sciences › Computer Science › Artificial Intelligence › Cryptographic Implementations and Security
- Physical Sciences › Computer Science › Artificial Intelligence › Computer Science and Engineering
- Keywords
- medical image encryption, AES-128, key sharing, brain MRI, smart healthcare, encryption throughput, NPCR and UACI
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