Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis
Open accessAbstract
Background Allergic rhinitis is a chronic respiratory disorder with a detrimental impact on health-related quality of life (HRQOL) and health status. Enhancement and maintenance of patient function and well-being are therefore considered as essential.Objective To determine whether long-term treatment with levocetirizine 5mg improves HRQOL and health status in persistent allergic rhinitis (PER) patients assessed with RQLQ and SF-36 scales over a 6-month period.Methods The Xyzal in PER Trial (XPERT) was a multi-center, double-blind, parallel-group study. A total of 551 patients were randomized to receive levocetirizine 5mg or placebo once daily for 6 months and assessed for symptoms, HRQOL (Rhinoconjunctivitis Quality of Life Questionnaire: RQLQ) and health status (SF-36). Sensitivity of the RQLQ and SF-36 to disease severity was tested to ensure their suitability for use in PER patients. Treatment effect was assessed by means of repeated measures analyses.Results Over the 6-month treatment period, levocetirizine showed statistically significant improvements over placebo in HRQOL (P < 0.001 for all RQLQ domains and overall scores) and health status (P < or = 0.004 for SF-36 physical and mental summary scores; P < 0.05 for all SF-36 scales). The relative improvement of levocetirizine over placebo exceeded the predefined clinically meaningful threshold of 30% for all RQLQ scores and the improvement from baseline was 3 times the established MID for RQLQ.Conclusion The RQLQ and SF-36 could be used to measure HRQOL and health status in PER patients. Long-term treatment with levocetirizine provides sustained improvement of HRQOL and reduces disease burden in PER patients.
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Two randomized controlled trials of levocetirizine over 6 months showed that both placebo and treatment groups experienced clinically and statistically significant improvements in generic and disease-specific quality of life, with greater improvement in the treatment arm.
“These RCTs show that over a 6-month period, both the placebo and treatment group experience clinically and statistically significantly improvements in generic and disease-specific QOL; however, the improvement is greater in the treatment arm.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [677]
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Self-citation
- Authors
- Walter Canonica, G., Bousquet, J., Van Hammée, G., Bachert, C., Durham, S. R., Klimek, L., Mullol, J., & Van Cauwenberge, P. B.
- Affiliations
- Hôpital Arnaud de Villeneuve (FR)
- Ghent University Hospital (BE)
- Royal Brompton Hospital (GB)
- Zentrum für Rhinologie und Allergologie (DE)
- Hospital Clínic de Barcelona (ES)
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 100
- Issue
- 10
- Pages
- 1706-1715
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2047870486
- Cited by
- 44
- References
- 40
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2012: 2
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- levocetirizine, persistent allergic rhinitis, health-related quality of life, health status, Rhinoconjunctivitis Quality of Life Questionnaire, SF-36, disease burden, patient-reported outcomes
- MeSH terms
- Double-Blind Method, Health Status, Humans, Piperazines, Quality of Life, Surveys and Questionnaires, Rhinitis, Allergic, Perennial, Treatment Outcome, Cetirizine, Histamine H1 Antagonists, Non-Sedating
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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