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Cited by 111Chronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in AgingClinical Nutrition and Gastroenterology

Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD

Open access
Sugawara, Keiyu, Takahashi, Hitomi, Kashiwagura, Takeshi, Yamada, Kohko, Yanagida, Satoko, Homma, Mitsunobu, Dairiki, Kazuo, Sasaki, Hajime +3 more·2012·Respiratory Medicine
DOI 10.1016/j.rmed.2012.07.001
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Abstract

Background One of the major pathophysiologies in advanced chronic obstructive pulmonary disease (COPD) has been attributed to systemic inflammation. Meta-analysis of the 2005 Cochrane Database concluded the effect of nutritional supplementation alone on stable COPD was insufficient to promote body weight gain or exercise capacity. The aim of this study was to investigate the effectiveness of nutritional supplementation therapy using a nutritional supplement containing whey peptide with low-intensity exercise therapy in stable elderly patients with COPD. Method In stable elderly COPD patients with %IBW and %FEV(1) of less than 110 and 80%, respectively, anti-inflammatory nutritional supplementation therapy was added to low-intensity exercise therapy. Thirty-six COPD patients were divided into those with and those without the ingestion of an anti-inflammatory nutritional supplement containing whey peptide, which exhibited an anti-inflammatory effect. These two groups were designated as the nutritional support and the control groups, respectively. The body composition, skeletal muscle strength, exercise tolerance, health-related QOL (HRQOL), and inflammatory cytokines were evaluated before and three months after nutritional support combined with exercise therapy in both the nutritional support group and the control group. Results In the nutritional support group, the body weight, %IBW, FM, energy intake, %AC, Alb, PImax, PEmax, 6MWD, WBI, emotional function, and CRQ total were significantly increased, and the levels of hsCRP, IL-6, IL-8, and TNF-α were reduced significantly, while no significant change was noted in any item of physiological evaluation or any biomarker in the control group. Conclusion Concomitant use of a anti-inflammatory nutritional supplement containing whey peptide, which exhibits an anti-inflammatory effect, with exercise therapy in stable elderly COPD patients with %IBW<110% and %FEV(1)<80% may not only increase body weight but may also inhibit systemic inflammation and thus improve exercise tolerance and HRQOL.

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  • Five RCTs were identified comparing combined exercise and nutrition interventions to singular exercise interventions in older people with malnutrition or at risk of malnutrition.

    “Five RCTs were identified comparing combined exercise and nutrition interventions to singular exercise interventions in older people with malnutrition or at risk of J o u r n a l P r e -p r o o f malnutrition (83,87,(94)(95)(96).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [94]

  • Four RCTs reported positive effects of oral nutritional supplementation in combination with exercise training on various outcome parameters, including body weight, MNA score, and muscle mass.

    “Four of them -one in COPD patients (94), two in rehabilitation patients (95,96), one in malnourished patients with lower limb fracture (87) -reported positive effects of oral nutritional supplementation in combination with exercise training on various outcome parameters, e.g.BW (87,94,95), MNA score (95), muscle mass (95,96).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [94]

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Authors
Sugawara, K., Takahashi, H., Kashiwagura, T., Yamada, K., Yanagida, S., Homma, M., Dairiki, K., Sasaki, H., Kawagoshi, A., Satake, M., & Shioya, T.
Affiliations
  • Akita City Hospital (JP)
  • Meiji (Japan) (JP)
  • Akita University (JP)
Corresponding author
Shioya, Takanobu
ORCID
Venue
Respiratory Medicine
Publisher
Elsevier BV
Published
2012-11
Volume
106
Issue
11
Pages
1526-1534
ISSN
0954-6111 (ISSN-L)
DOI
10.1016/j.rmed.2012.07.001
OpenAlex
W1971486155
Cited by
111
References
7
Citations by year
2026: 5 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 3 · 2012: 1
FWCI
5.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Respiratory Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
chronic obstructive pulmonary disease, whey peptides, dietary supplementation, systemic inflammation, elderly patients, weight gain, body composition, skeletal muscle strength, exercise tolerance, health-related quality of life, inflammatory cytokines, C-reactive protein, interleukin-6, interleukin-8, TNF-α
MeSH terms
Whey Proteins, Aged, Anti-Inflammatory Agents, Energy Intake, Combined Modality Therapy, Exercise Therapy, Female, Humans, Male, Milk Proteins, Quality of Life, Weight Gain, Treatment Outcome, Dietary Supplements, Pulmonary Disease, Chronic Obstructive

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