Cited by 77Exercise and Physiological ResponsesGenetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging

Open access
Rosa, Eloi F., Silva, Antonio C., Ihara, Silvia S. M., Mora, Oswaldo A., Aboulafia, Jeannine, Nouailhetas, Viviane L. A.·2005·Journal of Applied Physiology

Abstract

Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. The introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum. This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00417.2005

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Intrinsic adaptations to endurance training, such as decreased blood flow, tissue hypoxia, and increased transit and absorptive capacity, can lead to changes in the GI tract.

    “intrinsic adaptations to endurance training, such as decreased blood flow, tissue hypoxia, and increased transit and absorptive capacity can lead to changes in the GI tract [114, 115].”

    From The athletic gut microbiota (2020) · cites this paper as [115]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rosa, E. F., Silva, A. C., Ihara, S. S. M., Mora, O. A., Aboulafia, J., & Nouailhetas, V. L. A.
Affiliations
Universidade Federal de São Paulo (BR)
Venue
Journal of Applied Physiology
Published
2005-10
Volume
99
Issue
4
Pages
1569-1575
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2008936154
Cited by
77
References
45
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 5
FWCI
4.25
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
aging, aerobic exercise, oxidative stress, intestinal smooth muscle, skeletal muscle, myocardium, sarcopenia, cardiac hypertrophy, lipid peroxidation, mitochondrial cristae, lamellar bodies, treadmill running, gastrocnemius, ileum, physical performance
MeSH terms
Aging, Animals, Body Weight, Carbachol, Heart, Ileum, Intestines, Male, Mice, Inbred C57BL, Muscle, Smooth, Myocardium, Organ Size, Papillary Muscles, Physical Conditioning, Animal, Potassium Chloride, Lipid Peroxidation, Muscle, Skeletal, Muscarinic Agonists, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review