Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging
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Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. The introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum. This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated.
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Intrinsic adaptations to endurance training, such as decreased blood flow, tissue hypoxia, and increased transit and absorptive capacity, can lead to changes in the GI tract.
“intrinsic adaptations to endurance training, such as decreased blood flow, tissue hypoxia, and increased transit and absorptive capacity can lead to changes in the GI tract [114, 115].”
From The athletic gut microbiota (2020) · cites this paper as [115]
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Intestinal Mucosal Lesion in Low-Flow States
Chiu, C.-J. (1970) · Archives of Surgery · doi:10.1001/archsurg.1970.01340280030009 · Cited by 1,809 · see citing works
Lipid peroxidation damage to cell components.
Tappel, A. L. (1973) · PubMed · Cited by 910 · see citing works
Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems
Davies, K. J. A. (2000) · IUBMB Life · doi:10.1080/713803728 · Cited by 774 · see citing works
Fraga, C. G., Leibovitz, B. E., & Tappel, A. L. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90023-8 · Cited by 679 · see citing works
Type of activity: resistance, aerobic and leisure versus occupational physical activity
Howley, E. T. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200106001-00005 · Cited by 672 · see citing works
Oxidants and antioxidants in exercise
Sen, C. K. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.3.675 · Cited by 628 · see citing works
Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems
Davies, K. J. A. (2000) · IUBMB Life · doi:10.1080/15216540051081010 · Cited by 608 · see citing works
Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 460 · see citing works
The UFAW Handbook on the Care and Management of Laboratory Animals.
(1958) · Archives of Ophthalmology · doi:10.1001/archopht.1958.00940081000029 · Cited by 451 · see citing works
Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants
Liu, J., Yeo, H. C. H., Övervik-Douki, E., Hagen, T. M., Doniger, S. J., Chu, D. W., Brooks, G. A., & Ames, B. N. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.21 · Cited by 435 · see citing works
Dröge, W. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_14 · Cited by 415 · see citing works
Antioxidant enzyme response to exercise and aging
Ji, L. L. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199302000-00011 · Cited by 388 · see citing works
Cardiovascular Physiology—Changes With Aging
Cheitlin, M. D. (2003) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2003.01751.x · Cited by 361 · see citing works
Beckman, K. B., & Ames, B. N. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50027-4 · Cited by 307 · see citing works
Schefer, V., & Talan, M. I. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02032-2 · Cited by 278 · see citing works
Doxorubicin-dependent lipid peroxidation at low partial pressures of O2
Winterbourn, C. C., Gutteridge, J. M. C., & Halliwell, B. B. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90028-5 · Cited by 272 · see citing works
Hedrich, H. J. (2012) · doi:10.1016/c2009-0-60982-x · Cited by 259 · see citing works
Responses of glutathione system and antioxidant enzymes to exhaustive exercise and hydroperoxide
Ji, L., & Fu, R. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.2.549 · Cited by 221 · see citing works
Chakravarthy, M., Joyner, M., & Booth, F. (2002) · Mayo Clinic proceedings · doi:10.4065/77.2.165 · Cited by 210 · see citing works
Fall in the number of myenteric neurons in aging guinea pigs
Gabella, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90516-7 · Cited by 187 · see citing works
Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant Systems
Ji, L. L., Leeuwenburgh, C., Leichtweis, S. B., Gore, M., Fiebig, R., Hollander, J. M., & Bejma, J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09896.x · Cited by 179 · see citing works
DeMaria, A. N., Neumann, A., Lee, G., Fowler, W., & Mason, D. T. (1978) · Circulation · doi:10.1161/01.cir.57.2.237 · Cited by 166 · see citing works
Effect of Training on Antioxidant Capacity, Tissue Damage, and Endurance of Adult Male Rats
Venditti, P., & Meo, S. D. (1997) · International Journal of Sports Medicine · doi:10.1055/s-2007-972671 · Cited by 141 · see citing works
Altered regional blood flow responses to submaximal exercise in older rats
Musch, T. I., Eklund, K. E., Hageman, K. S., & Poole, D. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00729.2003 · Cited by 140 · see citing works
The Effect of Long‐term Dietary Supplementation with Antioxidantsa
Meydani, M., Lipman, R. D., Han, S. N., Wu, D., Beharka, A. A., MARTIN, K. R., Bronson, R. T., Cao, G., Smith, D. E., & Meydani, S. N. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09915.x · Cited by 129 · see citing works
Exercise and oxidative stress methodology: a critique
Jenkins, R. R. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.670s · Cited by 127 · see citing works
Saltzman, J. R., & Russell, R. M. (1998) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70005-4 · Cited by 115 · see citing works
Muscular adaptations to resistance exercise in the elderly.
Narici, M. V., Reeves, N. D., Morse, C. I., & Maganaris, C. N. (2004) · PubMed · Cited by 111 · see citing works
Physical Activity and Oxidative Stress During Aging
Polidori, M. C., Mecocci, P., Cherubini, A., & Senin, U. (2000) · International Journal of Sports Medicine · doi:10.1055/s-2000-8881 · Cited by 105 · see citing works
Is Aging As Complex As It Would Appear?
Kirkwood, T., & Franceschi, C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38685.x · Cited by 104 · see citing works
Nutrient absorption and intestinal adaptation with ageing
Woudstra, T. D., & Thomson, A. B. R. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0262 · Cited by 102 · see citing works
Endurance training attenuates exercise-induced oxidative stress in erythrocytes in rat
Öztaşan, N., Tayşi, S., Gümüştekin, K., Altınkaynak, K., Aktas, Ö., Timur, H., Şıktar, E., Keleş, M. S., Akar, S., Akçay, F., et al. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-1029-6 · Cited by 102 · see citing works
Ageing: definitions, mechanisms and the magnitude of the problem
Balcombe, N. R., & Sinclair, A. J. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0244 · Cited by 87 · see citing works
Morán, M., Delgado, J. F., González, B., Manso, R., & Megı́as, A. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.0001-6772.2003.01244.x · Cited by 66 · see citing works
Kohut, M. L., Thompson, J. R., Lee, W.-L., & Cunnick, J. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00792.2003 · Cited by 48 · see citing works
Anaesthetic considerations for laparoscopic cholecystectomy
Leonard, I., & Cunningham, A. J. (2002) · Best practice & research. Clinical anaesthesiology · doi:10.1053/bean.2001.0204 · Cited by 44 · see citing works
Exercise training increases the näive to memory T cell ratio in old mice
Woods, J. A., Ceddia, M. A., Zack, M. D., Lowder, T., & Lu, Q. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00030-8 · Cited by 42 · see citing works
Gastrointestinal diseases in the elderly
Holt, P. R. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00007 · Cited by 34 · see citing works
Löfgren, M., Fagher, K., Wede, O. K., & Arner, A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.027060 · Cited by 25 · see citing works
Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonists
Kobashi Yeda, L., Breuing, E. P., & Markus, R. P. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90683-1 · Cited by 15 · see citing works
Dietary lipids modify the age-associated changes in intestinal uptake of fructose in rats
Drozdowski, L. A., Woudstra, T. D., Wild, G., Clandinin, M. T., & Thomson, A. B. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00311.2003 · Cited by 10 · see citing works
Clues to ageing from cells, organs and outer space
Kinney, J. M., & Allison, S. P. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00002 · Cited by 6 · see citing works
Rf, O., & Cs, T. (1988) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Human gut microbiota/microbiome in health and diseases: a review
Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294 · see citing works
Estaki, M., Pither, J., Baumeister, P., Little, J. P., Gill, S. K., Ghosh, S., Ahmadi-Vand, Z., Marsden, K. R., & Gibson, D. L. (2016) · Microbiome · doi:10.1186/s40168-016-0189-7 · Cited by 476 · see citing works
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
“Simultaneously, intrinsic adaptations to endurance training, such as decreased blood flow, tissue hypoxia, and increased transit and absorptive capacity can lead to changes in the GI tract [114, 115].”
BackgroundPhysical inactivity: associated diseases and disorders.
Knight, J. A. (2012) · PubMed · Cited by 208 · see citing works
Novel quantitative phenotypes of exercise training in mouse models
De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00694.2005 · Cited by 197 · see citing works
Ventura‐Clapier, R., Mettauer, B., & Bigard, X. A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.003 · Cited by 130 · see citing works
Fell, J. W., & Williams, A. D. (2008) · Journal of Aging and Physical Activity · doi:10.1123/japa.16.1.97 · Cited by 116 · see citing works
Lin, J., Lopez, E. F., Jin, Y., Remmen, H. V., Bauch, T. D., Han, H., & Lindsey, M. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.005 · Cited by 116 · see citing works
Sugawara, K., Takahashi, H., Kashiwagura, T., Yamada, K., Yanagida, S., Homma, M., Dairiki, K., Sasaki, H., Kawagoshi, A., Satake, M., et al. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.07.001 · Cited by 111 · see citing works
Leem, Y., Lim, H., Shim, S., Cho, J., Kim, B., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22075 · Cited by 105 · see citing works
Animal models in the study of exercise-induced cardiac hypertrophy
Wang, Y., Wisløff, U., & Kemi, O. J. (2010) · Physiological Research · doi:10.33549/physiolres.931928 · Cited by 103 · see citing works
Inactivity‐induced oxidative stress: A central role in age‐related sarcopenia?
Derbré, F., Gratas‐Delamarche, A., Gómez‐Cabrera, M. C., & Viña, J. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2011.654268 · Cited by 89 · see citing works
Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., Chang, L., Wang, H., Li, Y., Long, J., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.001 · Cited by 86 · see citing works
Corsetti, G., Pasini, E., D’Antona, G., Nisoli, E., Flati, V., Assanelli, D., Dioguardi, F. S., & Bianchi, R. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.078 · Cited by 78 · see citing works
Effects of cafeteria diet on the jejunum in sedentary and physically trained rats
Scoaris, C. R., Rizo, G. V., Roldi, L. P., de Moraes, S. M. F., de Proença, A. R. G., Peralta, R. M., & Natali, M. R. M. (2009) · Nutrition · doi:10.1016/j.nut.2009.04.012 · Cited by 73 · see citing works
Yang, Y., Shi, Y., Wiklund, P., Tan, X., Wu, N., Zhang, X., Tikkanen, O., Zhang, C., Munukka, E., & Cheng, S. (2017) · Nutrients · doi:10.3390/nu9080792 · Cited by 72 · see citing works
Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function
Rosa, E. F., Takahashi, S., Aboulafia, J., Nouailhetas, V. L. A., & Oliveira, M. G. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01158.2006 · Cited by 72 · see citing works
Self-citationOxidative stress in older adults: effects of physical fitness
Traustadóttir, T., Davies, S. S., Su, Y., Choi, L., Brown‐Borg, H. M., Roberts, L. J., & Harman, S. M. (2011) · AGE · doi:10.1007/s11357-011-9277-6 · Cited by 72 · see citing works
Kain, V., Ingle, K. A., Kachman, M. T., Baum, H., Shanmugam, G., Rajasekaran, N. S., Young, M. E., & Halade, G. V. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00297.2017 · Cited by 62 · see citing works
Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool
Wang, X., Pickrell, A. M., Rossi, S. G., Pinto, M., Dillon, L. M., Hida, A., Rotundo, R. L., & Moraes, C. T. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt251 · Cited by 54 · see citing works
Small intestinal disorders in the elderly
Thomson, A. B. R. (2009) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2009.10.009 · Cited by 54 · see citing works
Redox homeostasis and age‐related deficits in neuromuscular integrity and function
Sakellariou, G. K., Lightfoot, A. P., Earl, K. E., Stofanko, M., & McDonagh, B. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12223 · Cited by 49 · see citing works
Holland, A. M., Hyatt, H. W., Smuder, A. J., Sollanek, K. J., Morton, A. B., Roberts, M. D., & Kavazis, A. N. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1500-6 · Cited by 43 · see citing works
Sarcopenia in older mice is characterized by a decreased anabolic response to a protein meal
van Dijk, M., Nagel, J., Dijk, F. J., Salles, J., Verlaan, S., Walrand, S., van Norren, K., & Luiking, Y. C. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.11.014 · Cited by 41 · see citing works
Morphological changes in the enteric nervous system of aging and APP23 transgenic mice
Ginneken, C. J. V., Schäfer, K., Dam, D. V., Huygelen, V., & Deyn, P. P. D. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.030 · Cited by 41 · see citing works
Ventura‐Clapier, R. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-013 · Cited by 38 · see citing works
Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview
Ghosh, S., Golbidi, S., Werner, I., Verchere, C. B., & Laher, I. (2010) · Clinical Science · doi:10.1042/cs20090389 · Cited by 37 · see citing works
The Aged Intestine: Performance and Rejuvenation
Wang, Q., Qi, Y., Shen, W., Xu, J., Wang, L., Chen, S., Hou, T., & Si, J. (2021) · Aging and Disease · doi:10.14336/ad.2021.0202 · Cited by 35 · see citing works
McMahon, C. D., Chai, R. J., Radley‐Crabb, H. G., Watson, T. J., Matthews, K. G., Sheard, P. W., Soffe, Z., Grounds, M. D., & Shavlakadze, T. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12200 · Cited by 33 · see citing works
Aerobic exercise affects C57BL/6 murine intestinal contractile function
de Lira, C. A. B., Vancini, R. L., Ihara, S. S. M., da Silva, A. C., Aboulafia, J., & Nouailhetas, V. L. A. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0689-7 · Cited by 27 · see citing works
Self-citationRosa, E. F., Ribeiro, R. F., Pereira, F. M. T., Freymüller, E. H., Aboulafia, J., & Nouailhetas, V. L. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91166.2008 · Cited by 26 · see citing works
Self-citationAraujo, L. C. D. C., de Souza, I. L. L., Vasconcelos, L. H. C., Brito, A. D. F., Queiroga, F. R., Silva, A. S., da Silva, P. M., Cavalcante, F. D. A., & da Silva, B. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00103 · Cited by 25 · see citing works
Self-citationDamaging effects of intense repetitive treadmill running on murine intestinal musculature
Rosa, E. F., Freymüller, E. H., Ihara, S. S. M., Aboulafia, J., & Nouailhetas, V. L. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00377.2007 · Cited by 24 · see citing works
Self-citationLong, Y., Chow, S. K., Cui, C., Wong, R. M. Y., Qin, L., Law, S. W., & Cheung, W. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.06.003 · Cited by 23 · see citing works
Gavin, T. P., Westerkamp, L. M., & Zwetsloot, K. A. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01609.x · Cited by 23 · see citing works
Jin, S., Cui, S., Mu, X., Liu, Z., Han, Y., Cui, T., Xiong, W., Wei, X., & Zhang, X. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30924-8 · Cited by 22 · see citing works
Effect of lifestyle on age-related mitochondrial protein oxidation in mice cardiac muscle
Padrão, A. I., Ferreira, R. M., Vitorino, R. M. P., Alves, R. M. P., Figueiredo, P., Duarte, J. A., & Amado, F. M. L. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2100-3 · Cited by 21 · see citing works
Moderate-intensity treadmill exercise training decreases murine cardiomyocyte cross-sectional area
Sturgeon, K. M., Muthukumaran, G., Ding, D., Bajulaiye, A., Ferrari, V. A., & Libonati, J. R. (2015) · Physiological Reports · doi:10.14814/phy2.12406 · Cited by 19 · see citing works
Chronic aerobic swimming exercise promotes functional and morphological changes in rat ileum
Araujo, L. C. D. C., de Souza, I. L. L., Vasconcelos, L. H. C., Brito, A. D. F., Queiroga, F. R., Silva, A. S., da Silva, P. M., Cavalcante, F. D. A., & da Silva, B. A. (2015) · Bioscience Reports · doi:10.1042/bsr20150001 · Cited by 16 · see citing works
Self-citationRoss, M., Lithgow, H., Hayes, L. D., & Florida-James, G. D. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_12 · Cited by 16 · see citing works
Efeitos do exercício físico sobre o trato gastrintestinal
de Lira, C. A. B., Vancini, R. L., da Silva, A. C., & Nouailhetas, V. L. A. (2008) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922008000100012 · Cited by 40 · see citing works
Self-citationSouza, M. R. D. A., Pimenta, L., Pithon‐Curi, T. C., Bucci, M., Fontinele, R. G., & de Souza, R. R. (2014) · Microscopy Research and Technique · doi:10.1002/jemt.22394 · Cited by 13 · see citing works
Free Radicals and Gastrointestinal Disorders
Brown, K., Molcan, E., Rajendiran, E., Nusrat, A., Baker, J., Ruscheinsky, S., & Gibson, D. L. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_137 · Cited by 12 · see citing works
Sports Activities and Cardiovascular System Change
ŠTURSOVÁ, P., Budinskaya, K., Nováková, Z., Dobšák, P., & Babula, P. (2023) · Physiological Research · doi:10.33549/physiolres.935238 · Cited by 11 · see citing works
Ko, S.-H., Baeg, M. K., Jung, H., Kim, P., & Choi, M. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.13002 · Cited by 11 · see citing works
Redox Homeostasis in Age-Related Muscle Atrophy
Sakellariou, G. K., & McDonagh, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_13 · Cited by 11 · see citing works
Exercise changes the size of cardiac neurons and protects them from age-related neurodegeneration
Gama, E. F., Santarém, J. M., Liberti, É. A., Filho, W. J., & de Souza, R. R. (2009) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2009.09.004 · Cited by 10 · see citing works
The Interplay of Gut Microbiome in Health and Diseases
Mishra, T. K., Mallik, B., Kesheri, M., & Kanchan, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-1769-9_1 · Cited by 9 · see citing works
Lee, E. K., Jung, K. J., Choi, J., Kim, H. J., Han, Y. K., Jeong, K., Ji, A., Park, J., Yu, B. P., & Chung, H. Y. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.019 · Cited by 9 · see citing works
Schmitt, A., Haug, A.-L., Schlegel, F., Fragasso, A., & Munz, B. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-018-0914-1 · Cited by 7 · see citing works
Interval training does not decrease oxidative stress in the heart of mice
da Silva, L. A., Tromm, C. B., da Rosa, G. L., Gonçalves, C. L., Pinho, C. A., de Souza, C. T., STRECK, E. L., & Pinho, R. A. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.12.062 · Cited by 6 · see citing works
Models to Investigate Cardiac Metabolism
Schwarzer, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802394-5.00008-x · Cited by 6 · see citing works
Tsuruta, T., Wakisaka, M., Watanabe, T., Nishijima, A., Ikeda, A., Teraoka, M., Wang, T., Chen, K., & Nishino, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125742 · Cited by 5 · see citing works
Rosa, E. F., Alves, G., Luz, J., Silva, S. M. A., Suchecki, D., Pesquero, J. B., Aboulafia, J., & Nouailhetas, V. L. A. (2014) · Physiological Research · doi:10.33549/physiolres.932562 · Cited by 5 · see citing works
Self-citationEfeito do treinamento físico em alterações induzidas pelo envelhecimento no músculo papilar do rato
Maifrino, L. B. M., Araújo, R. C., Faccini, C. C., Liberti, É. A., Gama, E. F., Ribeiro, A. A. C. M., & de Souza, R. R. (2009) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2009000500009 · Cited by 5 · see citing works
Exercise and Reactive Oxygen Species in Elderly -Exercise as Prevention of Oxidative Stress-
Masuda, K., Tanabe, K., & Kuno, S. (2006) · International Journal of Sport and Health Science · doi:10.5432/ijshs.4.348 · Cited by 5 · see citing works
Effect of bedrest on the human gut and oral microbiome: implications for frailty
Alvaro-Fuss, M., DeClercq, V., Blodgett, J. M., Theou, O., Langille, M. G. I., & Beiko, R. G. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113079 · Cited by 3 · see citing works
Ünsal, H., Ünsal, C., Üner, A. G., Yıldırım, E. K., Eki̇ci̇, M., Balkaya, M., & Belge, F. (2016) · Kafkas Universitesi Veteriner Fakultesi Dergisi · doi:10.9775/kvfd.2016.15949 · Cited by 3 · see citing works
Comparative Skeletal Muscle Aging
Marcinek, D. J., Wanagat, J., & Villarin, J. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_13 · Cited by 3 · see citing works
Histological Effects of Aging on Male Albino Rats Duodenum
Al-Qudah, M. M. (2014) · Cited by 2 · see citing works
Jimenes, D. R., Pereira, V. A. R., Pereira, A. V., Pedrosa, M. M. D., Berti, J. A., Sant’Ana, D. D. M. G., & Barbosa, C. P. (2020) · Research Society and Development · doi:10.33448/rsd-v9i9.7602 · Cited by 2 · see citing works
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch12 · Cited by 1 · see citing works
Efeitos do Treinamento Combinado Resistido-Aeróbio no Ventrículo Esquerdo de Rato Wistar
de Souza, M. R., Pimenta, L., Pithon‐Curi, T. C., & de Souza, R. R. (2014) · Revista Brasileira de Ciência e Movimento · doi:10.18511/0103-1716/rbcm.v22n2p72-77
Aboulafia, J., Nouailhetas, V. L. A., Rosa, E. F., Ribeiro, R. F., Pereira, F. M. T., & Freymüller, E. H. (2015)
Self-citationde Abreu, E. S., Alves, J. O., dos Santos, A. C. C., Soares Marreiros Ferraz, A., & Ceccatto, V. M. (2024) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.5281/zenodo.14532643
Cardiac Aging in Female Wistar Rat Models With Sedentary or Physicaly Active Lifestyle
Hoffmann, M. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/qtk2-ae50
Major, J. A. D. A., Clébis, N. K., Mari, R. D. B., Gagliardo, K. M., Guimarães, J. P., de Souza, R. R., Stabille, S. R., Dias, N. S. D. O., & Germano, R. D. M. (2016) · Arquivos de Ciências Veterinárias e Zoologia da UNIPAR · doi:10.25110/arqvet.v18i3.2015.5531
Exercise-Induced Fatigue and Recovery in the Ageing Athlete
Fell, J. W. (2006) · Griffith Research Online · doi:10.25904/1912/1059
Physical Inactivity is not the Same as Sedentarism: The Harm of Prolonged Sitting to Human Health
Nouailhetas, V. L. (2017) · MOJ Anatomy & Physiology · doi:10.15406/mojap.2017.03.00110
Self-citationEffect of Aging on the Histological Structure of the Duodenum Wall in Male Albino Rats
Ali, R. A., Abdelrahim, E. A., Ahmed, Y. A. G., & Abdel-lateif, S. M. (2020) · SVU-International Journal of Medical Sciences · doi:10.21608/svuijm.2020.123754
Cardiometabolic adaptations to altered fuel supply, Ca2+ handling and exercise
Boardman, N. T. (2011) · NORA - Norwegian Open Research Archives
Mida, M., Michalik, M., Majda, U., Maruszak, A., Kwiecień, J., Stołtny, J., Goryczka, J., Lisik, M., Kimla, W., & Hajok, N. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.1(49).2026.4850
Exercise-induced mitochondrial remodeling in energy-demanding organs during aging
Zhou, Z., Gao, J., Wang, M., & Zhang, H. (2026) · iScience · doi:10.1016/j.isci.2026.116791
- Authors
- Rosa, E. F., Silva, A. C., Ihara, S. S. M., Mora, O. A., Aboulafia, J., & Nouailhetas, V. L. A.
- Affiliations
- Universidade Federal de São Paulo (BR)
- ORCID
- Rosa, Eloi F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-10
- Volume
- 99
- Issue
- 4
- Pages
- 1569-1575
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2008936154
- Cited by
- 77
- References
- 45
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 5
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- aging, aerobic exercise, oxidative stress, intestinal smooth muscle, skeletal muscle, myocardium, sarcopenia, cardiac hypertrophy, lipid peroxidation, mitochondrial cristae, lamellar bodies, treadmill running, gastrocnemius, ileum, physical performance
- MeSH terms
- Aging, Animals, Body Weight, Carbachol, Heart, Ileum, Intestines, Male, Mice, Inbred C57BL, Muscle, Smooth, Myocardium, Organ Size, Papillary Muscles, Physical Conditioning, Animal, Potassium Chloride, Lipid Peroxidation, Muscle, Skeletal, Muscarinic Agonists, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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