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Cited by 38Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchOccupational exposure and asthma

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Lung function impairment increases with age of diagnosis in adult onset asthma

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Porsbjerg, Celeste, Lange, Peter, Ulrik, Charlotte Suppli·2015·Respiratory Medicine
DOI 10.1016/j.rmed.2015.04.012
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Abstract

Background Asthma-onset in older individuals has been associated with an accelerated decline in lung function, but direct comparisons with younger adults have not been reported.Methods In a random population sample comprising 4983 individuals from the Copenhagen City Heart Study without asthma at baseline, we compared young (<35 years), middle-aged (35-64 years) and older (>64 years) adults with newly diagnosed asthma during a 10-year follow-up.Results The proportion of cases with newly diagnosed asthma during follow-up was similar across age groups (Older adults: 7% (84/1168), middle-aged adults: 7% (223/3147), and young adults: 6% (42/668) (p = ns)). In all three age groups, lung function was reduced at baseline in subjects who were subsequently diagnosed with asthma, but most pronounced in those >35 years. (Mean FEV1%: Young 90.2% (±13.9), middle-aged 80.8% (±20.8), and older adults 80.8% (±24.2), p < 0.001). Furthermore, incident asthma was associated with an accelerated decline in lung function in older adults (young adults 11.0 mL/year, middle-aged adults 18.2 mL/year, and older adults 30.8 mL/year). These differences were independent of FEV1 at baseline and smoking status, and were not explained by undiagnosed asthma in older adults, as the frequency of respiratory symptoms, including wheeze, was similar in all three age groups at baseline.Conclusions Asthma was diagnosed as frequently in older as in younger adults. Preexisting symptoms were equally common, but lung function was more reduced pre-diagnosis, and declined more rapidly in older adults. This emphasizes the need for a high level of therapeutic attention in patients with asthma diagnosed late in life.

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Crossref · 10.1016/j.rmed.2015.04.012

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  • Adults who developed new-onset asthma had reduced lung function at baseline.

    “It has been suggested that adults who developed new-onset asthma had reduced lung function at baseline (172, 173), but it is unknown whether lower lung function before early adulthood, in the absence of childhood asthma, predisposes to “true” adult onset asthma.”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [172]

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Metadata

Authors
Porsbjerg, C., Lange, P., & Ulrik, C. S.
Affiliations
University of Copenhagen (DK)
Corresponding author
  • Porsbjerg, Celeste
  • Lange, Peter
  • Ulrik, Charlotte Suppli
ORCID
Venue
Respiratory Medicine
Publisher
Elsevier BV
Published
2015-07
Volume
109
Issue
7
Pages
821-827
ISSN
0954-6111 (ISSN-L)
DOI
10.1016/j.rmed.2015.04.012
OpenAlex
W1990775993
Cited by
38
References
32
Citations by year
2026: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 2
FWCI
3.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Respiratory Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Capital Region of Copenhagen
  • Danish Heart Foundation
  • Danish Lung Foundation
  • Velux Foundation
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
adult-onset asthma, lung function decline, FEV1, age at diagnosis, newly diagnosed asthma, undiagnosed asthma, wheezing, smoking, Copenhagen City Heart Study
MeSH terms
Adult, Aged, Asthma, Denmark, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Male, Middle Aged, Population Surveillance, Respiratory Function Tests, Retrospective Studies, Time Factors, Vital Capacity, Incidence, Age of Onset, Young Adult

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