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Adherence to COPD treatment: Myth and reality
Open accessAbstract
COPD is a chronic disease in which effective management requires long-term adherence to pharmacotherapies but the level of adhesion to the prescribed medications is very low and this has a negative influence on outcomes. There are several approaches to detect non-adherence, such as pharmacy refill methods, electronic monitoring, and self-report measures, but they are all burdened with important limitations. Medication adherence in COPD is multifactorial and is affected by patients (health beliefs, cognitive abilities, self-efficacy, comorbidities, psychological profile, conscientiousness), physicians (method of administration, dosing regimen, polypharmacy, side effects), and society (patient-prescriber relationship, social support, access to medication, device training, follow-up). Patient-health care professional communication, especially that between patient and physician or pharmacist, is central to optimizing patient adherence. However, the most realistic approach is to keep in mind that non-adherence is always possible, indeed, probable.
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“Previous studies suggested that the misuse or rejection of medication or NIV can be influenced by some psychological factors such as anxiety, depression, health beliefs, and cognitive impairment (27–29); the unacknowledged recognition of the illness; and the use of different devices and medications due to comorbidities (30–32).”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [29]
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- Rolnick, 2013, Patient characteristics associated with medication adherence, Clin. Med. Res., 11, 54, 10.3121/cmr.2013.1113 · DOI
Cited by
Sorted by citations
Cazzola, M., Cavalli, F., Usmani, O. S., & Rogliani, P. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1739021 · Cited by 76
“Nevertheless, the documentation that in COPD [3] adherence to inhalation medication is device-related is sufficient on its own to highlight the importance of the device in therapeutic adherence [4].”
BackgroundSelf-citationDoxofylline is not just another theophylline!
Matera, M. G., Page, C. P., & Cazzola, M. (2017) · International Journal of COPD · doi:10.2147/copd.s150887 · Cited by 64
“There are now a bewildering array of inhaled devices and formulations of drugs available for the treatment of asthma and COPD, which are often associated with poor adherence.(49,50) Thus, the use of an orally active drug that is safe, effective and relatively inexpensive is to be encouraged, particularly for patients…”
Self-citationInhaler Adherence in COPD: A Crucial Step Towards the Correct
Turégano-Yedro, M., Trillo‐Calvo, E., Ros, F. M. N., Viejo, J. D. M., Villaescusa, C. G., Sustaeta, J. M. E., Doña, E., & Navarrete, B. A. (2023) · International Journal of COPD · doi:10.2147/copd.s431829 · Cited by 50
“18,19 Finally, in some patients, adherence is not correct due to difficulties in the inhalation technique, which may be influenced by the presence of cognitive impairment or pulmonary hyperinflation as a marker of disease severity.”
BackgroundEffects of a COPD self-management support intervention: a randomized controlled trial
Bringsvor, H., Langeland, E., Oftedal, B., Skaug, K., Assmus, J., & Bentsen, S. (2018) · International Journal of COPD · doi:10.2147/copd.s181005 · Cited by 36
Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities
Matera, M. G., Hanania, N. A., Maniscalco, M., & Cazzola, M. (2023) · Drugs & Aging · doi:10.1007/s40266-023-01038-0 · Cited by 40
“It is necessary to develop interventions that address adherence barriers specific to older patients (such as cognition, polypharmacy, and immobility), identify strategies for continuous inhaler technique support outside of the professional healthcare setting, and assess the impact of prescribing multiple types of inha…”
BackgroundSelf-citation
Metadata
- Authors
- Rogliani, P., Ora, J., Puxeddu, E., Matera, M. G., & Cazzola, M.
- Affiliations
- University of Rome Tor Vergata (IT)
- Policlinico Tor Vergata (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Cazzola, Mario
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 129
- Pages
- 117-123
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2624975405
- Cited by
- 102
- References
- 46
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 16 · 2023: 20 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 7 · 2018: 5 · 2017: 4
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Keywords
- chronic obstructive pulmonary disease, medication adherence, non-compliance, pharmacotherapy, patient beliefs, polypharmacy, social support, access to medicines
- MeSH terms
- Assessment of Medication Adherence, Administration, Inhalation, Adrenal Cortex Hormones, Adrenergic beta-Agonists, Classification, Communication, Female, Humans, Health Knowledge, Attitudes, Practice, Male, Pharmacists, Physicians, Social Support, Survival Analysis, Drug Monitoring, Pulmonary Disease, Chronic Obstructive, Medication Adherence, Self Report
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