Efficacy of a multifactorial intervention on therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): a randomized controlled trial
Open accessAbstract
BACKGROUND: Therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is poor. This study evaluated the effectiveness of a multifactorial intervention on improving the therapeutic adherence in chronic obstructive pulmonary disease (COPD) patients with scheduled inhalation therapy. METHODS: The study design consisted of a randomised controlled trial in a primary care setting. 146 patients diagnosed with COPD were randomly allocated into two groups using the block randomisation technique. One-year follow-ups with three visits were performed. The intervention consisted of motivational aspects related to adherence (beliefs and behaviour) in the form of group and individual interviews, cognitive aspects in the form of information about the illness and skills in the form of training in inhalation techniques. Cognitive-emotional aspects and training in inhalation techniques were reinforced during all visits of the intervention group. The main outcome measure was adherence to the medication regimen. Therapeutic adherence was determined by the percentage of patients classified as good adherent as evaluated by dose or pill count. RESULTS: Of the 146 participants (mean age 69.8 years, 91.8% males), 41.1% reported adherence (41.9% of the control group and 40.3% of the intervention group). When multifactorial intervention was applied, the reported adherence was 32.4% for the control group and 48.6% for the intervention group, which showed a statistically significant difference (p = 0.046). Number needed to treat is 6.37. In the intervention group, cognitive aspects increased by 23.7% and skilled performance of inhalation techniques increased by 66.4%. The factors related to adherence when multifactorial intervention was applied were the number of exacerbations (OR = 0.66), visits to health centre (OR = 0.93) and devices (OR = 2.4); illness severity (OR = 0.67), beta-2-adrenergic (OR = 0.16) and xantine (OR = 0.19) treatment; activity (OR = 1.03) and impact (OR = 1.03) scales of the Saint George Respiratory Questionnaire. CONCLUSION: Application of the multifactorial intervention designed for this study (COPD information, dose reminders, audio-visual material, motivational aspects and training in inhalation techniques) resulted in an improvement in therapeutic adherence in COPD patients with scheduled inhalation therapy. TRIAL REGISTRATION: Current Controlled Trials ISRCTN18841601.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The study will require 150 subjects based on statistical analysis, with recruitment between 128 and 172 depending on statistical power.
“Based on statistical analysis, preventive inherent power and sample size [40] we anticipate that the study will require 150 subjects. We will recruit between 128 subjects (statistical power of 0.80; α = 0.05; 1 − β = 0.80; t (126) =1.97) and 172 subjects (statistical power equal to 0.90; α = 0.05; 1 − β = 0.90; t (170) = 1.97).”
From A psychological intervention to promote acceptance and adherence to non-invasive ventilation in people with chronic obstructive pulmonary disease: study protocol of a randomised controlled trial. (2017) · cites this paper as [33]
The Methods (Participants, design and setting; page not specified) reports a sample-size calculation using 80% statistical power and a 95% confidence level. It describes a COPD trial with 146 enrolled patients, but does not support the citing study’s estimate of 150 subjects or its recruitment range of 128–172 at 80–90% power. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPsychosocial interventions, especially those incorporating cognitive elements, reduce psychological distress.
“This approach is supported by recent meta-analyses of controlled studies that emphasize that psychosocial interventions, especially those incorporating cognitive elements, reduce psychological distress (41) and, when based on meditative and relaxation practices, have the potential to improve physical and psychological outcomes (42).”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [42]
The Methods > Intervention section describes cognitive and motivational elements, but their purpose was to improve treatment adherence in patients with COPD. The Results > Intervention effectiveness and Conclusion report adherence and disease-knowledge outcomes, not a reduction in psychological distress. Searches for psychological distress, anxiety, and depression found no passage establishing the attributed effect. (LLM, conf=0.75)
Experimental — accuracy not yet measuredNo study has identified the individual psychological factors that increase the risk of rejection or improper use of NIV.
“No study has identified the individual psychological factors that increase the risk of rejection or improper use of NIV.”
From A psychological intervention to promote acceptance and adherence to non-invasive ventilation in people with chronic obstructive pulmonary disease: study protocol of a randomised controlled trial. (2017) · cites this paper as [33]
The Background says COPD adherence studies have focused more on measuring adherence than on factors affecting it. The Discussion addresses motivation and incorrect inhaler use, but the passages found when searching for NIV, rejection, and psychological risk factors do not address whether any study has identified psychological predictors of NIV rejection or improper use. (LLM, conf=0.77)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
Bryan, H., Carpenter, C., & Hoult, S. (2010) · SAGE Publications Ltd eBooks · doi:10.4135/9781446251607.n8 · Cited by 4,174 · see citing works
McLeod, J. (1999) · SAGE Publications Ltd eBooks · doi:10.4135/9781849209588.n8 · Cited by 3,964 · see citing works
Buist, A. S., McBurnie, M. A., Vollmer, W. M., Gillespie, S., Burney, P., Mannino, D. M., Menezes, A. M., Sullivan, S. D., Lee, T. A., Weiss, K. B., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61377-4 · Cited by 2,364 · see citing works
DiMatteo, M. R. (2004) · Medical Care · doi:10.1097/01.mlr.0000114908.90348.f9 · Cited by 2,169 · see citing works
Global burden of COPD: risk factors, prevalence, and future trends
Mannino, D. M., & Buist, A. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61380-4 · Cited by 2,077 · see citing works
Trends in the leading causes of death in the United States, 1970-2002.
Jemal, A., Ward, E. M., Hao, Y.-P., & Thun, M. (2005) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.294.10.1255 · Cited by 1,054 · see citing works
Chronic obstructive pulmonary disease
Decramer, M., Janssens, W., & Miravitlles, M. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60968-9 · Cited by 975 · see citing works
Inhaler mishandling remains common in real life and is associated with reduced disease control
Melani, A. S., Bonavia, M., Cilenti, V., Cinti, C., Lodi, M., Martucci, P., Serra, M., Scichilone, N., Sestini, P., Aliani, M., et al. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.01.005 · Cited by 947 · see citing works
Kunz, R., & Oxman, A. D. (1998) · BMJ · doi:10.1136/bmj.317.7167.1185 · Cited by 770 · see citing works
RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION
Sackett, D., Gibson, E., Taylor, D. W., Haynes, R. B., Hackett, B. C., Roberts, R., & Johnson, A. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92192-3 · Cited by 502 · see citing works
Bourbeau, J., & Bartlett, S. J. (2008) · Thorax · doi:10.1136/thx.2007.086041 · Cited by 490 · see citing works
Herdman, M., Badia, X. C., & Berra, S. (2001) · Atención Primaria · doi:10.1016/s0212-6567(01)70406-4 · Cited by 456 · see citing works
Ferrer, M., Alonso, J., Prieto, L. M., Plaza, V., Monsó, E., Marrades, R. M., Aguar, M. C., Khalaf, A., & Anto, J. M. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09061160 · Cited by 432 · see citing works
Medication adherence issues in patients treated for COPD
Restrepo, R. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s3036 · Cited by 407 · see citing works
Treatment of Reflux Oesophagitis
COLE, P. V. (1988) · Inpharma Weekly · doi:10.1007/bf03308057 · Cited by 391 · see citing works
Gender differences in COPD: are women more susceptible to smoking effects than men?
Sørheim, I.-C., Johannessen, A., Gulsvik, A., Bakke, P. S., Silverman, E. K., & DeMeo, D. L. (2010) · Thorax · doi:10.1136/thx.2009.122002 · Cited by 338 · see citing works
Tantucci, C., & Modina, D. (2012) · International Journal of COPD · doi:10.2147/copd.s27480 · Cited by 323 · see citing works
DUNEAR-JACOB, J., Erlen, J. A., Schlenk, E. A., Ryan, C. M., Sereika, S. M., & Doswell, W. M. (2000) · Annual Review of Nursing Research · doi:10.1891/0739-6686.18.1.48 · Cited by 323 · see citing works
Factors Associated With Medication Nonadherence in Patients With COPD
George, J., Kong, D. C. M., Thoman, R., & Stewart, K. (2005) · CHEST Journal · doi:10.1378/chest.128.5.3198 · Cited by 319 · see citing works
Guía Española de la EPOC (GesEPOC). Tratamiento farmacológico de la EPOC estable
Miravitlles, M., Soler‐Cataluña, J. J., Rubio, M. C., Molina, J., Almagro, P., Quintano, J. A., Riesco, J. A., Trigueros, J. A., Piñera, P., Simón, A., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2012.04.001 · Cited by 256 · see citing works
Foreman, M. G., Zhang, L., Murphy, J. R., Hansel, N. N., Make, B. J., Hokanson, J. E., Washko, G. R., Regan, E. A., Crapo, J. D., Silverman, E. K., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1928oc · Cited by 237 · see citing works
Gallefoss, F., Bakke, P. S., & RSGAARD, P. K. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.3.9804047 · Cited by 235 · see citing works
Functional Status and Quality of Life in Chronic Obstructive Pulmonary Disease
Reardon, J. Z., Lareau, S. C., & ZuWallack, R. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.08.005 · Cited by 216 · see citing works
Approaches to Patient Education: Emphasizing the Long-Term Value of Compliance and Persistence
Gold, D. T., & McClung, B. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.12.021 · Cited by 202 · see citing works
Adherence and persistence with fluticasone propionate/salmeterol combination therapy
Bender, B. G., Pedan, A., & Varasteh, L. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.07.002 · Cited by 193 · see citing works
Gallefoss, F., & Bakke, P. S. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9901028 · Cited by 187 · see citing works
Long-Term Metered-Dose Inhaler Adherence in a Clinical Trial. The Lung Health Study Research Group
Rand, C. S., Nides, M. A., Cowles, M. K., Wise, R. A., & Connett, J. E. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633711 · Cited by 181 · see citing works
The Asia Pacific COPD Roundtable Group (2005) · Respirology · doi:10.1111/j.1440-1843.2005.00692.x · Cited by 177 · see citing works
Guía clínica SEPAR-ALAT de diagnóstico y tratamiento de la EPOC
Peces‐Barba, G., Barberà, J. A., Agustí, A. G. N., Casanova, C., Casas, A., Alonso, J. L. I., Jardim, J. R., Varela, V. L., Monsó, E., Montemayor, T., et al. (2008) · Archivos de Bronconeumología · doi:10.1157/13119943 · Cited by 168 · see citing works
Factors Associated with Medication Adherence in Patients with Chronic Obstructive Pulmonary Disease
Ágh, T., Inotai, A., & Mészáros, Á. (2011) · Respiration · doi:10.1159/000324453 · Cited by 157 · see citing works
Khdour, M. R., Hawwa, A. F., Kidney, J. C., Smyth, B. M., & McElnay, J. C. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1279-5 · Cited by 126 · see citing works
Inhalatory therapy training: a priority challenge for the physician.
Melani, A. S. (2007) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 113 · see citing works
Medication non‐adherence—exploring the conceptual mire
Lehane, E. A., & McCarthy, G. M. (2009) · International Journal of Nursing Practice · doi:10.1111/j.1440-172x.2008.01722.x · Cited by 94 · see citing works
Hesselink, A. E., Penninx, B. W. J. H., van der Windt, D., van Duin, B. J., de Vries, P. W., Twisk, J. W. R., Bouter, L. M., & van Eijk, J. T. M. (2004) · Patient Education and Counseling · doi:10.1016/j.pec.2003.08.007 · Cited by 88 · see citing works
van Onzenoort, H. V., Verberk, W., Kessels, A., Kroon, A., Neef, C., van der Kuy, P. M., & de Leeuw, P. D. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2009.207 · Cited by 83 · see citing works
Soriano, J. B., Miravitlles, M., Borderías, L., Duran‐Tauleria, E., Rio, F. G., Martínez, J., Montemayor, T., Muñoz, L., Piñeiro, L., Sánchez, G., et al. (2010) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2010.06.008 · Cited by 82 · see citing works
Does patient education modify behaviour in the management of COPD?
Worth, H., & Dhein, Y. (2003) · Patient Education and Counseling · doi:10.1016/s0738-3991(03)00101-0 · Cited by 81 · see citing works
Krigsman, K., Nilsson, J. L. G., & Ring, L. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1321 · Cited by 76 · see citing works
Piñeiro, F., Gil, V., Donis, M., Orozco, D., Pastor, R., & Merino, J. (1997) · PubMed · Cited by 68 · see citing works
Persistence with inhaled corticosteroid therapy in daily practice
Postma, N. S., Gerrits, C. M. J. M., Lammers, J. J., Raaijmakers, J. A. M., & Herings, R. M. C. (2004) · Respiratory Medicine · doi:10.1016/j.rmed.2004.01.014 · Cited by 62 · see citing works
van Grunsven, P. M., van Schayck, O. C. P., van Deuveren, M., van Herwaarden, C., Akkermans, R. P., & van Weel, C. (2000) · Journal of Asthma · doi:10.3109/02770900009055445 · Cited by 54 · see citing works
Correlates of adherence to respiratory drugs in COPD patients
Laforest, L., Denis, F., Ganse, E. H. V., Ritleng, C., Saussier, C., Passante, N., Devouassoux, G., Chatte, G., Freymond, N., & Pachéco, Y. (2010) · Primary Care Respiratory Journal · doi:10.4104/pcrj.2010.00004 · Cited by 52 · see citing works
Normativa sobre la utilización de fármacos inhalados
Giner, J., Basualdo, L. V., Casán, P., Hernández, C., Macián, V., Martínez, I., & Mengíbar, A. M. A. (2000) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(15)30231-3 · Cited by 51 · see citing works
Soriano, J. B., Miravitlles, M., Borderías, L., Duran‐Tauleria, E., Rio, F. G., Martínez, J., Montemayor, T., Muñoz, L., Piñeiro, L., Sánchez, G., et al. (2010) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(11)60005-0 · Cited by 47 · see citing works
Cómo diagnosticar el cumplimiento terapéutico en atención primaria
Pérez, G., Fernández, F. L., Crespo, F. M., Aj, G. R., Prados Torres, D., de la Cuesta, S., & Alarcon, F. J. (2000) · Cited by 40 · see citing works
Variations in FEV1 decline over time in chronic obstructive pulmonary disease and its implications
Tashkin, D. P. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32835d8ea4 · Cited by 38 · see citing works
Gutiérrez, F. J. Á., Miravitlles, M., Rubio, M. C., Gobartt, E., López, F., & Martín, A. (2007) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(07)60026-3 · Cited by 38 · see citing works
Impacto de la EPOC en la vida diaria de los pacientes. Resultados del estudio multicéntrico EIME
Gutiérrez, F. J. Á., Miravitlles, M., Rubio, M. C., Gobartt, E., López, F., & Martín, A. (2007) · Archivos de Bronconeumología · doi:10.1157/13098416 · Cited by 34 · see citing works
Barnestein‐Fonseca, P., Leiva-Fernández, J., Vidal-España, F., Ruíz, A., Prados-Torres, D., & Leiva-Fernández, F. (2011) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-11-6 · Cited by 34 · see citing works
Self-citationLeiva-Fernández, F., Leiva-Fernández, J., Zubeldia-Santoyo, F., Ruíz, A., Prados-Torres, D., & Barnestein‐Fonseca, P. (2012) · Trials · doi:10.1186/1745-6215-13-64 · Cited by 31 · see citing works
Self-citationBarnestein‐Fonseca, P., Leiva-Fernández, J., Vidal-España, F., Ruíz, A., Prados-Torres, D., & Leiva-Fernández, F. (2011) · Trials · doi:10.1186/1745-6215-12-40 · Cited by 27 · see citing works
Self-citationCharacteristics of outpatients with COPD in daily practice: The E4 Spanish project
Viejo-Bañuelos, J. L., Bastida, A. P., & Fueyo-Rodríguez, A. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.043 · Cited by 24 · see citing works
Guía Española de la EPOC (GesEPOC). Tratamiento farmacológico de la EPOC estable
Miravitlles, M., Soler‐Cataluña, J. J., Rubio, M. C., Molina, J., Almagro, P., Quintano, J. A., Riesco, J. A., Trigueros, J. A., Piñera, P., Simón, A., et al. (2012) · Atención Primaria · doi:10.1016/j.aprim.2012.04.005 · Cited by 22 · see citing works
López, J. B. C., & Pozo-Rodrı́guez, F. (1997) · PubMed · Cited by 17 · see citing works
Esteban, C., Moraza, J., Aburto, M., Quintana, J. M., & Capelastegui, A. (2003) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(03)75437-4 · Cited by 17 · see citing works
Vargas, A. M. F., Zafra, M. J. B., Leiva-Fernández, F., Crespo, F. M., Ruíz, A., & Torres, D. P. (2001) · Atención Primaria · doi:10.1016/s0212-6567(01)70457-x · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Haynes RB Ackloo E Sahota N McDonald HP Yao X Intervenciones para mejorar la adherencia a la medicación (Revisión Cochrane traducida) La Biblioteca Cochrane Plus 2008 2 Oxford: Update Software Ltd Available in: http://www.update-software.com. (Translate fromThe Cochrane Library, 2008 Issue 2. Chichester, UK: John Wiley & Sons, Ltd)
- Giner J Basualdo LV Casan P Hernandez C Macián V Martinez I Utilización de fármacos inhalados: Recomendaciones SEPAR Available at: http://www.separ.es/biblioteca-1/Biblioteca-para-Profesionales/consensos (accessed sept 2012) 10726183
- Piñeiro F Gil V Donis M Orozco D Pastor A Merino J Validez de 6 métodos indirectos para valorar el cumplimiento del tratamiento farmacológico en la hipertensión arterial Aten Primaria 1997 19 7 372 376 9254142
- Cabello JB Pozo F Métodos de investigación en cardiología clínica(X): estudios de evaluación de las pruebas diagnósticas en cardiología Rev Esp Cardiol 1997 50 507 519 9304178
Cited by
Sorted by citations
Lenferink, A., Brusse-Keizer, M., van der Valk, P. D., Frith, P. A., Zwerink, M., Monninkhof, E. M., van der Palen, J., & Effing, T. W. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011682.pub2 · Cited by 328 · see citing works
Cross, A. J., Elliott, R. A., Petrie, K., Kuruvilla, L., & George, J. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012419.pub2 · Cited by 269 · see citing works
Self-management interventions for people with chronic obstructive pulmonary disease
Schrijver, J., Lenferink, A., Brusse-Keizer, M., Zwerink, M., van der Valk, P. D., van der Palen, J. A. M., & Effing, T. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002990.pub4 · Cited by 170 · see citing works
New insights to improve treatment adherence in asthma and COPD
George, M., & Bender, B. G. (2019) · Patient Preference and Adherence · doi:10.2147/ppa.s209532 · Cited by 128 · see citing works
Jansen, E. M., van de Hei, S. J., Dierick, B. J. H., Kerstjens, H. A. M., Kocks, J. W. H., & van Boven, J. F. M. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-20-2360 · Cited by 126 · see citing works
Status of and strategies for improving adherence to COPD treatment
López-Campos, J. L., Quintana‐Gallego, E., & Hernández, L. C. (2019) · International Journal of COPD · doi:10.2147/copd.s170848 · Cited by 111 · see citing works
Adherence in Asthma and COPD: New Strategies for an Old Problem
George, M. (2018) · Respiratory Care · doi:10.4187/respcare.05905 · Cited by 107 · see citing works
Adherence to COPD treatment: myth and reality
Rogliani, P., Ora, J., Puxeddu, E., Matera, M. G., & Cazzola, M. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.06.007 · Cited by 102 · see citing works
Dekhuijzen, R. P. N., Lavorini, F., Usmani, O. S., & van Boven, J. F. M. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.11.027 · Cited by 84 · see citing works
van Boven, J. F. M., Ryan, D. P., Eakin, M. N., Canonica, G. W., Barot, A., & Foster, J. M. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2016.03.007 · Cited by 81 · see citing works
Papus, M., Dima, A. L., Viprey, M., Schott, A., Schneider, M. P., & Novais, T. (2022) · Patient Education and Counseling · doi:10.1016/j.pec.2022.06.013 · Cited by 70 · see citing works
Ceyhan, Y. Ş., & Kartin, P. T. (2022) · Trials · doi:10.1186/s13063-022-06603-3 · Cited by 66 · see citing works
van de Hei, S. J., Dierick, B. J. H., Aarts, J. E. P., Kocks, J. W. H., & van Boven, J. F. M. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.05.025 · Cited by 55 · see citing works
Janjua, S., Pike, K. C., Carr, R., Coles, A., Normansell, R., & Batavia, M. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013381.pub2 · Cited by 52 · see citing works
Turan, O., Turan, P. A., & Mirici, A. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12823 · Cited by 47 · see citing works
Banfi, P. I., Cappuccio, A., Latella, M., Reale, L., Muscianisi, E., & Marini, M. G. (2018) · International Journal of COPD · doi:10.2147/copd.s148685 · Cited by 44 · see citing works
Adherence to Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review
Świątoniowska-Lonc, N., Chabowski, M., Polański, J., Mazur, G. J., & Jankowska‐Polańska, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_477 · Cited by 29 · see citing works
Volpato, E., Banfi, P., & Pagnini, F. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001053 · Cited by 24 · see citing works
“These statistical analyses were conducted taking into account data from scientific research with comparable primary outcome (45).”
MethodEffects of targeting disease and medication management interventions towards patients with COPD
van Boven, J. F. M., Stuurman-Bieze, A. G. G., Hiddink, E., & Postma, M. J. (2015) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1110129 · Cited by 24 · see citing works
Dąbrowska, M., Łuczak-Woźniak, K., Miszczuk, M., Domagała, I., Lubański, W., Leszczyński, A., Maskey‐Warzęchowska, M., Rubinsztajn, R., Hermanowicz-Salamon, J., & Krenke, R. (2019) · Respiratory Care · doi:10.4187/respcare.06740 · Cited by 24 · see citing works
Davis, E., Marra, C. A., Gamble, J., Farrell, J., Lockyer, J., FitzGerald, J. M., Abu-Ashour, W., Gillis, C. J., & Hawboldt, J. (2016) · Trials · doi:10.1186/s13063-016-1623-7 · Cited by 23 · see citing works
Alwashmi, M. F., FitzPatrick, B., Davis, E., Farrell, J., Gamble, J., & Hawboldt, J. (2020) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466620951044 · Cited by 23 · see citing works
Inhalation therapy in the next decade: Determinants of adherence to treatment in asthma and COPD
Donner, C. F., Amaducci, S., Bacci, E., Baldacci, S., Bartoli, M. L., Beghi, G. M., Benfante, A., Brighindi, S., Casali, L., Castiglia, D., et al. (2018) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2018.886 · Cited by 21 · see citing works
Volpato, E., Banfi, P., & Pagnini, F. (2017) · Trials · doi:10.1186/s13063-017-1802-1 · Cited by 18 · see citing works
“quantifying adherence [32] and largely neglected predictors of nonadherence [33].”
BackgroundAdisa, R., Ufuah, U. F., & Ige, O. M. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11683-9 · Cited by 18 · see citing works
Medication Compliance in COPD Patients
Polański, J., Chabowski, M., Świątoniowska-Lonc, N., Mazur, G. J., & Jankowska‐Polańska, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_508 · Cited by 18 · see citing works
Effects of a Digital Self-care Intervention in Adults with COPD: A Pilot Study
Bugajski, A., Frazier, S. K., Cousin, L., Rechenberg, K., Brown, J. D., Lengerich, A. J., Moser, D. K., & Lennie, T. A. (2019) · Western Journal of Nursing Research · doi:10.1177/0193945919892282 · Cited by 17 · see citing works
Ahmed, R. E., Bdair, I. A., Al‐Mugheed, K., Alshahrani, S. H., Alalyani, M. M., Ramaiah, R., Abd-Elrahman, S. I., Mahmoud, S. A., & Arrab, M. M. (2023) · Healthcare · doi:10.3390/healthcare11030430 · Cited by 15 · see citing works
Do not do in COPD: consensus statement on overuse
Álvarez, F. V., Moreno-Zabaleta, R., Mira, J. J., Corbella, E. C., Lobato, S. D., González-Torralba, F., Hernando-Sanz, A., Núñez-Palomo, S., Salgado-Aranda, S., Simón-Rodríguez, B., et al. (2018) · International Journal of COPD · doi:10.2147/copd.s151939 · Cited by 15 · see citing works
Nguyen, T. N., Truong, M. T. X., Lam, D. N., Nguyen, H. T. T., Huynh, A. M., Duong, V. K., Vo, T. P. M., Nguyen, T. H. P., Cao, T. T. M., Pham, S. T., et al. (2023) · Patient Education and Counseling · doi:10.1016/j.pec.2023.108037 · Cited by 14 · see citing works
Regular access and adherence to medications of the specialized component of pharmaceutical services
Fritzen, J. S., Motter, F. R., & Paniz, V. M. V. (2017) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2017051006932 · Cited by 14 · see citing works
Toyama, T., Kawayama, T., Kinoshita, T., Imamura, Y., Yoshida, M., Takahashi, K., Fujii, K., Higashimoto, I., & Hoshino, T. (2018) · Internal Medicine · doi:10.2169/internalmedicine.0488-17 · Cited by 14 · see citing works
ADESÃO ÀS ORIENTAÇÕES NUTRICIONAIS: UMA REVISÃO DE LITERATURA
Estrela, K. C. A., Alves, A. C. D. C., Gomes, T. T., & Isosaki, M. (2017) · DEMETRA Alimentação Nutrição & Saúde · doi:10.12957/demetra.2017.22407 · Cited by 14 · see citing works
Vitacca, M., Paneroni, M., Fracassi, M., Mandora, E., Cerqui, L., Benedetti, G., Zanoni, C., Pluda, A., Bertacchini, L., & Fiorenza, D. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.04.010 · Cited by 12 · see citing works
Case, M. A., & Eakin, M. N. (2023) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2023.2239708 · Cited by 11 · see citing works
Ammous, O., Kampo, R. S., Wollsching-Strobel, M., Zimmermann, M., Andreas, S., Friede, T., Kroppen, D., Stanzel, S. B., Salem, S., Windisch, W., et al. (2024) · European Respiratory Review · doi:10.1183/16000617.0011-2024 · Cited by 11 · see citing works
Hendrychova, T., Svoboda, M., Malý, J., Vlček, J., Zimčíková, E., Dvořák, T., Zatloukal, J., Voláková, E., Plutinský, M., Brat, K., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.860270 · Cited by 11 · see citing works
Granata, N., Traversoni, S., Kardas, P., Kurczewska-Michalak, M., Costa, E. M., Midão, L., & Giardini, A. (2020) · Patient Education and Counseling · doi:10.1016/j.pec.2020.04.006 · Cited by 11 · see citing works
Leiva-Fernández, J., Vazquez-Alarcon, R., Aguiar-Leiva, V. P., Lobnig-Becerra, M., Leiva-Fernández, F., & Barnestein‐Fonseca, P. (2016) · Trials · doi:10.1186/s13063-016-1269-5 · Cited by 9 · see citing works
Self-citationRabahi, M. F., Silva, D. G. S. T., Silva, J. B., Ribeiro, L. S., & Conde, M. B. (2016) · International Journal of COPD · doi:10.2147/copd.s110779 · Cited by 8 · see citing works
Sommariva, S., Finch, A. P., & Jommi, C. (2015) · Multidisciplinary Respiratory Medicine · doi:10.1186/s40248-016-0038-3 · Cited by 3 · see citing works
Revue générale sur l’adhésion aux traitements inhalés de la BPCO
Dalon, F., Ganse, E. H. V., Silva, C. C. D., Nachbaur, G., Sail, L., & Belhassen, M. (2019) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2019.06.005 · Cited by 3 · see citing works
Plaza, V., Fernández, C., Curto, E., Bel, N. A.-O. M., Orue, M. I., Vega, J. M., Cosío, B. G., & Giner, J. (2020) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2020.09.001 · Cited by 2 · see citing works
Tiwari, R., Timilsina, M., & Banstola, S. (2024) · Journal of Health and Allied Sciences · doi:10.37107/jhas326 · Cited by 2 · see citing works
Yimenu, D. K., Quek, H. W., Rafeld, P., Hareem, A., Gebreyohannes, E. A., Wang, K., Seubert, L., Lee, K., & Page, A. T. (2025) · International Journal of Pharmacy Practice · doi:10.1093/ijpp/riaf060 · Cited by 1 · see citing works
Current treatments for chronic obstructive pulmonary disease (COPD)
Cope, G. F. (2014) · British Journal of Healthcare Management · doi:10.12968/bjhc.2014.20.8.372
Acevedo, J. I. E. (2015) · Journal of Pharmaceutical Care & Health Systems · doi:10.4172/2376-0419.1000137
Efek program manajemen diri pada pasien penyakit paru obstruktif kronik : Systematis review
Harniati, H., Syahrul, S., & Tahir, T. (2019) · Jurnal Keperawatan Muhammadiyah · doi:10.30651/jkm.v4i2.2878
Plaza, V., Fernández, C., Curto, E., Ortiz, M. B. A., Orue, M. I., Vega, J. M., Cosío, B. G., & Giner, J. (2021) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2020.09.006
Ahmed, R. E., & Bahgat, Z. F. (2022) · Tanta Scientific Nursing Journal · doi:10.21608/tsnj.2022.267658
Alnewar, P., Singh, S., Wanjari, M. B., Kothe, A., & Ankar, R. S. (2023) · Medical Science · doi:10.54905/disssi/v27i132/e103ms2601
Neuropsychiatric Disorders During Non-Invasive Ventilation
Castagna, A., Fabbo, G., & Ruberto, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-27968-3_36
Уразбаев, М. А., Халиуллин, Ф. А., Шарипов, И. М., & Клен, Е. Э. (2023) · Problems of Biological Medical and Pharmaceutical Chemistry · doi:10.29296/25877313-2023-07-04
Gomes, D. S., Seixas, C., & Cravo, J. M. (2025) · Jornal Brasileiro de Pneumologia · doi:10.36416/1806-3756/e20250393
Jarab, A. S., Al-Qerem, W. A., Alzoubi, K. H., Heshmeh, S. A., Momany, E. M. A., Hamarneh, Y. N. A., Mukattash, T. L., Eberhardt, J., Aburuz, S., & Akour, A. A. (2025) · Pharmacy Practice · doi:10.18549/pharmpract.2025.2.3142
Phuong, N. T., Phuc, N. D., Hang, N. T. T., Huong, D. T. L., & Thuy, P. N. (2026) · VNU Journal of Science Medical and Pharmaceutical Sciences · doi:10.25073/2588-1132/vnumps.4973
Zhu, Y., Chen, J., Li, S., Liu, B., Huang, M., Xue, L., Zheng, S., & Huang, H. (2026) · International Journal of COPD · doi:10.2147/copd.s623486
- Authors
- Leiva-Fernández, J., Leiva-Fernández, F., García-Ruiz, A., Prados-Torres, D., & Barnestein-Fonseca, P.
- Affiliations
- Área de Gestión Sanitaria Este de Málaga-Axarquía (ES)
- Venue
- BMC Pulmonary Medicine
- Published
- 2014-04-25
- Volume
- 14
- Issue
- 1
- Pages
- 70-70
- ISSN
- 1471-2466 (ISSN-L)
- PMC
- PMC4011779
- OpenAlex
- W1988780857
- Cited by
- 57
- References
- 56
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 1
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Pulmonary Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositorio Institucional de la Universidad de Málaga (University of Málaga) (submittedVersion, cc-by)
- Funders
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- chronic obstructive pulmonary disease, medication adherence, multifactorial intervention, patient education, motivational interviewing, primary care, inhaler devices, exacerbations, St George's Respiratory Questionnaire, illness beliefs, health behavior change, number needed to treat
- MeSH terms
- Assessment of Medication Adherence, Administration, Inhalation, Age Factors, Aged, Aged, 80 and over, Attitude to Health, Bronchodilator Agents, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Middle Aged, Primary Health Care, Reference Values, Respiratory Therapy, Severity of Illness Index, Sex Factors, Time Factors, Odds Ratio, Treatment Outcome, Drug Monitoring, Risk Assessment, Pulmonary Disease, Chronic Obstructive, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
