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Cited by 267

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Spectroscopic studies on the antioxidant activity of p-coumaric acid

Kiliç, Ismail, Yeşiloğlu, Yeşim·2013·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI 10.1016/j.saa.2013.06.110
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Abstract

p-coumaric acid (4-hydroxycinnamic acid), a phenolic acid, is a hydroxyl derivative of cinnamic acid. It decreases low density lipoprotein (LDL) peroxidation and reduces the risk of stomach cancer. In vitro radical scavenging and antioxidant capacity of p-coumaric acid were clarified using different analytical methodologies such as total antioxidant activity determination by ferric thiocyanate, hydrogen peroxide scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and superoxide anion radical scavenging, ferrous ions (Fe(2+)) chelating activity and ferric ions (Fe(3+)) reducing ability. p-Coumaric acid inhibited 71.2% lipid peroxidation of a linoleic acid emulsion at 45μg/mL concentration. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and ascorbic acid displayed 66.8%, 69.8%, 64.5% and 59.7% inhibition on the peroxidation of linoleic acid emulsion at the same concentration, respectively. In addition, p-coumaric acid had an effective DPPH scavenging, ABTS(+) scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, ferric ions (Fe(3+)) reducing power and ferrous ions (Fe(2+)) chelating activities. Also, those various antioxidant activities were compared to BHA, BHT, α-tocopherol and ascorbic acid as references antioxidant compounds. These results suggested that p-coumaric acid can be used in the p…

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Metadata

Authors
Kiliç, I., & Yeşiloğlu, Y.
Venue
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Publisher
Elsevier BV
Published
2013-11
Volume
115
Pages
719-724
ISSN
1386-1425
DOI
10.1016/j.saa.2013.06.110
Cited by
267
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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