Protective Effects of P-Coumaric Acid against Oxidant and Hyperlipidemia-an in Vitro and in Vivo Evaluation
Open accessAbstract
Dietary phenols are antioxidants with diverse physiological functions that are beneficial for human health. The objective of this research work was to investigate antioxidant activity of p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress in PC12 cells, and hypolipidemic effects on High fat-diet (HFD) mice model. The p-CA exhibited moderate antioxidant activity in the selected in vitro assay. The highest chelating activity of p-CA at 50 μg/mL was found to be 52.22%. Pretreatment with p-CA significantly enhanced cell viability of PC12 cell and suppressed AAPH-induced intracellular ROS generation and AAPH-induced LDH release. The hypolipidemic effects of p-CA (100 mg/kg BW) was directly linked to the increased expression of nuclear factor erythroid 2-related factor (Nrf2) by 2.0-fold, Glutathione peroxidase (Gpx) by 3.8-fold, Superoxide dismutase (SOD-1) by 1.6-fold, Heme oxygenase (HO-1) by 1.72-fold and NAD(P)H Quinone Dehydrogenase 1 (NQO-1) by 1.5-fold compared with HFD group. In addition to these effects, p-CA decreased total cholesterol and atherosclerosis index levels, and increased catalase (CAT) level in serum, total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) levels in liver as compared HFD group. Administration of p-CA also promoted the recovery of hyperlipidemia steatohepatitis in mice by ameliorating lipid peroxidation. These results suggested that p-CA is a potent antioxidant with potential therapeutic efficacy for treating hyperlipidemia symptoms.
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Treatment with p-CA promotes expression of Nrf2, with consequent increased levels of antioxidant enzymes including HO-1, SOD, NAD(P)H quinone dehydrogenase 1, CAT, and GPx.
“Being an antioxidant agent, the treatment with this acid promotes the expression of Nrf2, with the consequent increased levels of some antioxidant enzymes, including HO-1, SOD, NAD(P)H quinone dehydrogenase 1, CAT, and GPx [328].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [328]
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- Authors
- Shen, Y., Song, X., Li, L., Sun, J., Jaiswal, Y., Huang, J., Liu, C., Yang, W., Williams, L., Zhang, H., & Guan, Y.
- Affiliations
- University of Minnesota (US)
- Guangxi Academy of Agricultural Science (CN)
- North Carolina Agricultural and Technical State University (US)
- Jinan University (CN)
- Central South University of Forestry and Technology (CN)
- Nanjing University of Finance and Economics (CN)
- Jiangnan University (CN)
- Temple University (US)
- Corresponding author
- Guan, Yifu
- ORCID
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 111
- Pages
- 579-587
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2908302127
- Cited by
- 206
- References
- 42
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 34 · 2023: 39 · 2022: 35 · 2021: 29 · 2020: 18 · 2019: 6
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Postdoctoral Science Foundation (2016M602605)
- National Natural Science Foundation of China (21402166, 31670360, 31701594)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- p-coumaric acid, antioxidant activity, hyperlipidemia, oxidative stress, PC12 cells, high-fat diet, Nrf2, glutathione peroxidase, superoxide dismutase, heme oxygenase-1, NQO1, lipid peroxidation, steatohepatitis, atherosclerosis, catalase, total antioxidant capacity
- MeSH terms
- Animals, Antioxidants, Cell Survival, Coumaric Acids, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Hyperlipidemias, Male, Propionates, Lipid Peroxidation, Free Radical Scavengers, PC12 Cells, Treatment Outcome, Oxidative Stress, Mice, Rats, Diet, High-Fat
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