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Overcoming the challenges of membrane protein crystallography
Open accessAbstract
Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than 150 unique structures are available. Membrane proteins have proven to be difficult to study owing to their partially hydrophobic surfaces, flexibility and lack of stability. The field is now taking advantage of the high-throughput revolution in structural biology and methods are emerging for effective expression, solubilisation, purification and crystallisation of membrane proteins. These technical advances will lead to a rapid increase in the rate at which membrane protein structures are solved in the near future.
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Yang, Y., Hong, Y., Cho, E., Kim, G. B., & Kim, I. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1440131 · Cited by 258
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Metadata
- Authors
- Carpenter, E. P., Beis, K., Cameron, A. D., & Iwata, S.
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 18
- Issue
- 5
- Pages
- 581-586
- ISSN
- 0959-440X (ISSN-L)
- OpenAlex
- W2015214828
- Cited by
- 525
- References
- 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carpenter, E. P., Beis, K., Cameron, A. D., & Iwata, S. (2008). Overcoming the challenges of membrane protein crystallography. Current Opinion in Structural Biology. https://doi.org/10.1016/j.sbi.2008.07.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
