The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery
Open accessAbstract
Membrane proteins are of great research interest, particularly because they are rich in targets for therapeutic application. The suitability of various membrane proteins as targets for therapeutic formulations, such as drugs or antibodies, has been studied in preclinical and clinical studies. For therapeutic application, however, a protein must be expressed and purified in as close to its native conformation as possible. This has proven difficult for membrane proteins, as their native conformation requires the association with an appropriate cellular membrane. One solution to this problem is to use extracellular vesicles as a display platform. Exosomes and microvesicles are membranous extracellular vesicles that are released from most cells. Their membranes may provide a favourable microenvironment for membrane proteins to take on their proper conformation, activity, and membrane distribution; moreover, membrane proteins can cluster into microdomains on the surface of extracellular vesicles following their biogenesis. In this review, we survey the state‐of‐the‐art of extracellular vesicle (exosome and small‐sized microvesicle)‐based therapeutics, evaluate the current biological understanding of these formulations, and forecast the technical advances that will be needed to continue driving the development of membrane protein therapeutics.
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1 retracted
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Mesenchymal stromal/stem cell (MSC)-Derived exosomes in clinical trials
Lotfy, A., AboQuella, N. M., & Wang, H. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03287-7 · Cited by 482
Exosome engineering in cell therapy and drug delivery
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Metadata
- Authors
- Yang, Y., Hong, Y., Cho, E., Kim, G. B., & Kim, I.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 7
- Issue
- 1
- Pages
- 1440131-1440131
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W2793266847
- Cited by
- 258
- References
- 178
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, Y., Hong, Y., Cho, E., Kim, G. B., & Kim, I. (2018). Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery. Journal of Extracellular Vesicles. https://doi.org/10.1080/20013078.2018.1440131
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
