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Cited by 54Schizophrenia research and treatmentPsychopathy, Forensic Psychiatry, Sexual OffendingBipolar Disorder and Treatment

Hippocampus and amygdala volumes in children and young adults at high-risk of schizophrenia: Research synthesis

Ganzola, Rossana, Maziade, Michel, Duchesne, Simon·2014·Schizophrenia Research
DOI 10.1016/j.schres.2014.03.030
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Abstract

Background Studies have reported hippocampal and amygdala volume abnormalities in schizophrenic patients. It is necessary to explore the potential for these structures as early disease markers in subjects at high risk (HR) of schizophrenia. Methods We performed a review of 29 magnetic resonance imaging (MRI) studies measuring hippocampal and amygdala volumes in subjects at HR for schizophrenia. We reclassified subjects in 3 new HR categories: presence of only risk symptoms (psychotic moderate symptoms), presence of only risk factors (genetic, developmental or environmental), and presence of combined risk symptoms/factors. Results Hippocampal volume reductions were detected in subjects with first episode (FE) of psychosis, in all young adults and in adolescents at HR of schizophrenia. The loss of tissue was mainly located in the posterior part of hippocampus and the right side seems more vulnerable in young adults with only risk symptoms. Instead, the anterior sector seems more involved in HR subjects with genetic risks. Abnormal amygdala volumes were found in FE subjects, in children with combined risk symptoms/factors and in older subjects using different inclusion criteria, but not in young adults. Conclusion Hippocampal and amygdala abnormalities may be present before schizophrenia onset. Further studies should be conducted to clarify whether these abnormalities are causally or effectually related to neurodevelopment. Shape analysis could clarify the impact of environmenta…

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  • Individuals at ultra-high risk for the development of psychosis may also demonstrate reduced hippocampal volumes.

    “Individuals at ultra-high risk for the development of psychosis may also demonstrate reduced hippocampal volumes (80, 83).”

    From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [80]

  • The evidence for amygdalar volume differences in psychosis is more nuanced, with some studies of first episode psychosis revealing complex volume reduction while others did not show significant differences.

    “The evidence for amygdalar volume differences in psychosis is more nuanced (80) with some studies of first episode psychosis revealing complex volume reduction (81–83) while others did not show significant differences (84).”

    From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [80]

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Authors
Ganzola, R., Maziade, M., & Duchesne, S.
Affiliations
Institut Universitaire en Santé Mentale de Québec (CA)
Corresponding author
Ganzola, Rossana
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2014-06
Volume
156
Issue
1
Pages
76-86
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2014.03.030
OpenAlex
W2091628745
Cited by
54
References
2
Citations by year
2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 1
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Réseau en Bio-Imagerie du Quebec
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
hippocampal volume, amygdala volume
MeSH terms
Aging, Amygdala, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Risk Factors, Schizophrenia, Databases, Bibliographic

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