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Gradual vs. wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis
Abstract
To address whether wait discontinuation (i.e., introducing the new antipsychotic while maintaining the first for a period before initiating its discontinuation) is superior to non-wait discontinuation (i.e., initiating the first antipsychotic's discontinuation when introducing the new antipsychotic) in antipsychotic switching, we conducted a meta-analysis of randomized controlled trials comparing gradual vs. wait-and-gradual antipsychotic discontinuation in patients with schizophrenia. The meta-analysis of 5 studies (n=410) demonstrated no significant differences in any clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, between the two groups. These findings indicate either strategy can be used in clinical practice.
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There may be little difference in the risk of relapse with immediate and gradual antipsychotic stopping or switching.
“Evidence indicates there may be little difference in the risk of relapse with immediate and gradual antipsychotic stopping or switching.11”
From Stopping and switching antipsychotic drugs (2019) · cites this paper as [11]
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Cites
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Stopping and switching antipsychotic drugs
Keks, N., Schwartz, D., & Hope, J. (2019) · Australian Prescriber · doi:10.18773/austprescr.2019.052 · Cited by 63
Correll, C. U., Shi, L., Weiss, C., Hobart, M., Eramo, A., Duffy, R. A., Weiller, E., & Baker, R. A. (2019) · CNS Spectrums · doi:10.1017/s1092852918001086 · Cited by 16
Metadata
- Authors
- Takeuchi, H., Thiyanavadivel, S., Agid, O., & Remington, G.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Takeuchi, Hiroyoshi
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 189
- Pages
- 4-8
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2592870337
- Cited by
- 12
- References
- 1
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- antipsychotic switching
- MeSH terms
- Humans, Schizophrenia, Time Factors, Antipsychotic Agents, Randomized Controlled Trials as Topic, Drug Substitution
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