Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 328

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Daphnia magna model in the toxicity assessment of pharmaceuticals: A review

Tkaczyk, Angelika, Bownik, Adam, Dudka, Jarosław, Kowal, Krzysztof, Ślaska, Brygida·2021·Science of The Total Environment
DOI 10.1016/j.scitotenv.2020.143038
Open this paper in CoChat — free account

Abstract

Daphnia magna is one of the most commonly used model organism to assess toxicity of wide range of pharmaceuticals such as antibiotics, anticancer drugs, antidepressants, anti-inflammatory drugs, beta-blockers and lipid-regulating agents. Currently, daphnia toxicity tests based on immobilisation and lethality standardised by OECD, acute immobilisation test and reproduction test, are mainly used in toxicological studies. Detailed analysis of Daphnia biology allows distinguishing the swimming behaviour and physiological endpoints such as swimming speed, distance travelled, hopping frequency, heart rate, ingestion rate, feeding rate, oxygen consumption, thoracic limb activity which could be also useful in assessment of toxic effects. The advantage of behavioural and physiological parameters is the possibility to observe sublethal effects induced by lower concentrations of pharmaceuticals which would not be possible to notice by using OECD tests. Additionally, toxic effects of tested drugs could be assessed using enzymatic and non-enzymatic biomarkers of daphnia toxicity. This review presents scientific data considering characteristics of D. magna, analysis of immobilisation, lethality, reproductive, behavioural, physiological and biochemical parameters used in the toxicity assessment of pharmaceuticals. The aim of this paper is also to emphasize usefulness, advantages and disadvantages of these invertebrate model organisms to assess toxicity of different therapeutic classes of pharmaceuticals. Also, various examples of application of D. magna in studies on pharmaceutical toxicity are presented.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.scitotenv.2020.143038

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 60 references

Research works printed but not linked: 29

  1. Anderson, 1944, The toxicity thresholds of various substances found in industrial wastes as determined by the use of Daphnia magna, Sew. Work. J., 1156
  2. Argese, 2001, Assessment of chloroaniline toxicity by the submitochondrial particle assay, Environ. Toxicol. Chem. Int. J., 20, 826, 10.1002/etc.5620200418 · doi:10.1002/etc.5620200418
  3. Borgatta, 2015, The anticancer drug metabolites endoxifen and 4-hydroxy-tamoxifen induce toxic effects on Daphnia pulex in a two-generation study, Sci. Total Environ., 520, 232, 10.1016/j.scitotenv.2015.03.040 · doi:10.1016/j.scitotenv.2015.03.040
  4. Borgatta, 2016, Multigenerational effects of the anticancer drug tamoxifen and its metabolite 4-hydroxy-tamoxifen on Daphnia pulex, Sci. Total Environ., 545-546, 21, 10.1016/j.scitotenv.2015.11.155 · doi:10.1016/j.scitotenv.2015.11.155
  5. Bownik, 2018, Effects of apomorphine, a dopamine agonist, on Daphnia magna: imaging of swimming track density as a novel tool in the assessment of swimming activity, Sci. Total Environ., 635, 249, 10.1016/j.scitotenv.2018.04.157 · doi:10.1016/j.scitotenv.2018.04.157
  6. Bownik, 2019, Procaine penicillin alters swimming behaviour and physiological parameters of Daphnia magna, Environ. Sci. Pollut. Res. Int., 26, 18662, 10.1007/s11356-019-05255-2 · doi:10.1007/s11356-019-05255-2
  7. Bownik, 2019, Cisplatin affects locomotor activity and physiological endpoints of Daphnia magna, J. Hazard. Mater., 121259
  8. Bownik, 2020, Ketoprofen affects swimming behavior and impairs physiological endpoints of Daphnia magna, Sci. Total Environ., 725, 10.1016/j.scitotenv.2020.138312 · doi:10.1016/j.scitotenv.2020.138312
  9. Consi, 1990, Eye movements in Daphnia magna, J. Comp. Physiol. A., 166, 411, 10.1007/BF00204815 · doi:10.1007/bf00204815
  10. De Coen, 2001, The use of biomarkers in Daphnia magna toxicity testing V. In vivo alterations in the carbohydrate metabolism of Daphnia magna exposed to sublethal concentrations of mercury and lindane, Ecotoxicol. Environ. Saf., 48, 223, 10.1006/eesa.2000.2009 · doi:10.1006/eesa.2000.2009
  11. Dodson, 1991, Size-specific swimming behavior of Daphnia pulex, J. Plankton Res., 13, 1367, 10.1093/plankt/13.6.1367 · doi:10.1093/plankt/13.6.1367
  12. Dodson, 1997, Daphnia swimming behavior during vertical migration, J. Plankton Res., 19, 969, 10.1093/plankt/19.8.969 · doi:10.1093/plankt/19.8.969
  13. Dzialowski, 2006, Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna, Arch. Environ. Contam. Toxicol., 50, 503, 10.1007/s00244-005-0121-9 · doi:10.1007/s00244-005-0121-9
  14. Goodrich, 1990, A behavioral screening assay for Daphnia magna: a method to assess the effects of xenobiotics on spacial orientation, Environ. Toxicol. Chem. Int. J., 9, 21, 10.1002/etc.5620090104 · doi:10.1002/etc.5620090104
  15. Gorski, 1996, Free-swimming Daphnia pulex can avoid following Stokes’ law, Limnol. Oceanogr., 41, 1815, 10.4319/lo.1996.41.8.1815 · doi:10.4319/lo.1996.41.8.1815
  16. Hassold, 2009, Chronic toxicity of five structurally diverse demethylase-inhibiting fungicides to the crustacean Daphnia magna: a comparative assessment, Environ. Toxicol. Chem. Int. J., 28, 1218, 10.1897/08-339.1 · doi:10.1897/08-339.1
  17. Jeong, 2018, Mode of action characterization for adverse effect of propranolol in Daphnia magna based on behavior and physiology monitoring and metabolite profiling, Environ. Pollut., 233, 99, 10.1016/j.envpol.2017.10.043 · doi:10.1016/j.envpol.2017.10.043
  18. Lu, 2013, Effects of selected pharmaceuticals on growth, reproduction and feeding of Daphnia magna, Fresenius Environ. Bull., 22, 2583
  19. Øien, 2004, Daphnicle dynamics based on kinetic theory: an analogue-modelling of swarming and behaviour of daphnia, Bull. Math. Biol., 66, 1, 10.1016/S0092-8240(03)00065-X · doi:10.1016/s0092-8240(03)00065-x
  20. Oropesa, 2016, Assessment of the effects of the carbamazepine on the endogenous endocrine system of Daphnia magna, Environ. Sci. Pollut. Res. Int., 23, 17311, 10.1007/s11356-016-6907-7 · doi:10.1007/s11356-016-6907-7
  21. Oropesa, 2016, Oxidative stress responses of Daphnia magna exposed to effluents spiked with emerging contaminants under ozonation and advanced oxidation processes, Environ. Sci. Pollut. Res., 24, 1735, 10.1007/s11356-016-7881-9 · doi:10.1007/s11356-016-7881-9
  22. Pan, 2017, Lethal/sublethal responses of Daphnia magna to acute norfloxacin contamination and changes in phytoplankton-zooplankton interactions induced by this antibiotic, Sci. Rep., 7
  23. Pijanowska, 1997, Predators can induce swarming behaviour and locomotory responses in Daphnia, Freshw. Biol., 37, 649, 10.1046/j.1365-2427.1997.00192.x · doi:10.1046/j.1365-2427.1997.00192.x
  24. Pirow, 1999, The importance of the feeding current for oxygen uptake in the water flea Daphnia magna, J. Exp. Biol., 202, 553, 10.1242/jeb.202.5.553 · doi:10.1242/jeb.202.5.553
  25. Shimizu, 2002, Fractal analysis of Daphnia motion for acute toxicity bioassay, Environ. Toxicol., 17, 441, 10.1002/tox.10077 · doi:10.1002/tox.10077
  26. Simão, 2019, Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs, Sci. Total Environ., 662, 160, 10.1016/j.scitotenv.2019.01.187 · doi:10.1016/j.scitotenv.2019.01.187
  27. Tian, 2019, Chronic toxicological effects of carbamazepine on Daphnia magna Straus: effects on reproduction traits, body length, and intrinsic growth, Bull. Environ. Contam. Toxicol., 103, 723, 10.1007/s00128-019-02715-w · doi:10.1007/s00128-019-02715-w
  28. Villarroel, 1999, Daphnia magna feeding behavior after exposure to tetradifon and recovery from intoxication, Ecotoxicol. Environ. Saf., 44, 40, 10.1006/eesa.1999.1817 · doi:10.1006/eesa.1999.1817
  29. Vollmer, 2006, Vortex formation by active agents as a model for Daphnia swarming, Phys. Rev. E Stat. Nonlinear Soft Matter Phys., 73, 061924, 10.1103/PhysRevE.73.061924 · doi:10.1103/physreve.73.061924

Cited by

See all 328

Metadata

Authors
Tkaczyk, A., Bownik, A., Dudka, J., Kowal, K., & Ślaska, B.
Venue
Science of The Total Environment
Publisher
Elsevier BV
Published
2021-04
Volume
763
Pages
143038
ISSN
0048-9697 (ISSN-L)
DOI
10.1016/j.scitotenv.2020.143038
OpenAlex
W3093076357
Cited by
328
References
60
FWCI
12.21
Type
journal article
Language
en
Open access
closed
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Daphnia magna model in the toxicity assessment of pharmaceuticals: A review. https://app.cochat.ai/papers/10.1016/j.scitotenv.2020.143038
The paper
Tkaczyk, A., Bownik, A., Dudka, J., Kowal, K., & Ślaska, B. (2021). Daphnia magna model in the toxicity assessment of pharmaceuticals: A review. Science of The Total Environment. https://doi.org/10.1016/j.scitotenv.2020.143038

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.