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Early exposure to sunlight and allergic morbidity: The PARIS birth cohort
Open accessAbstract
The relationship between sunlight and allergies in children has received limited attention from researchers. We sought to explore how early exposure to solar radiation is associated with allergic morbidity within the PARIS birth cohort study. Our research dealt with children who attended at least one of two health checkups: at 18 months (n = 2012) and at 8-9 years (n = 1080). Early exposure to solar radiation was assessed using meteorological data (e.g., solar radiation, temperature, and relative humidity). Children with similar meteorological exposure trajectories were grouped by a longitudinal and multidimensional cluster analysis. The association between solar radiation exposure and allergic morbidity (i.e., allergic sensitization at 18 months and 8-9 years; current asthma, rhinitis, and eczema at 8-9 years) was quantified by multivariable logistic regression models adjusted for potential confounders. The effect modification of maternal vitamin D supplementation during pregnancy was tested. Four meteorological exposure trajectories were found. The trajectory with the highest exposure to early solar radiation had a reduced risk of sensitization at 8-9 years compared to the trajectory with the lowest exposure (p = 0.06). The association was statistically significant in the vitamin D supplementation group. Solar radiation during prenatal and postnatal periods was significantly associated with a lower risk of sensitization at 8-9 years (for one interquartile range (IQR) increase, adjusted odds ratio (aOR): 0.47; 95 % confidence interval (CI): 0.25-0.87 and 0.84; 0.7-1.00, respectively). Increased prenatal exposure to solar radiation was significantly associated with a lower risk of asthma at 8-9 years (for one IQR increase, aOR: 0.32; 95 % CI: 0.1-0.96). Early sunlight exposure may reduce the risk of sensitization and asthma in school-aged children, especially in those prenatally exposed to vitamin D. These findings highlight the importance of vitamin D in preventing allergic diseases in children, either through supplementation or sunlight exposure.
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“There was evidence that higher ambient solar radiation during pregnancy and the first year of life was associated with reduced allergen sensitisation at 8–9 years of age [e.g., the odds ratio for sensitisation to at least one inhalant allergen per one interquartile range increase in radiation was 0.49 (95% confidence interval 0.27–0.87)].”
In the citing paper
“There was a stronger association with prenatal maternal exposure than with postnatal exposure of the infant.”
In the citing paper
“The effects were most evident in children whose mothers had been supplemented with vitamin D during pregnancy, suggesting possible synergy between exposure to solar radiation and vitamin D.”
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Pinart, M., Benet, M., Annesi-Maesano, I., von Berg, A., Berdel, D., Carlsen, K. C. L., Carlsen, K.-H., Bindslev-Jensen, C., Eller, E., Fantini, M. P., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70277-7 · Cited by 334
Self-citationPhotoimmunology: how ultraviolet radiation affects the immune system
Bernard, J. J., Gallo, R. L., & Krutmann, J. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0185-9 · Cited by 329
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Cited by
Sorted by citations
Neale, P. J., Hylander, S., Banaszak, A. T., Häder, D.-P., Rose, K. C., Vione, D., Wängberg, S.-Å., Jansen, M. A. K., Busquets, R., Andersen, M. P. S., et al. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00687-x · Cited by 32
“The importance of early life exposure was exemplified by a study of 2260 children born in one of five maternity hospitals in Paris between 2003 and 2006 who underwent examinations at 18 months and/or 8 years of age [263].”
Metadata
- Authors
- Lefebvre, L., Amazouz, H., Rancière, F., & Momas, I.
- Affiliations
- Inserm (FR)
- Corresponding author
- Rancière, Fanny
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 930
- Pages
- 172543
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W4394840093
- Cited by
- 7
- References
- 2
- Citations by year
- 2026: 5 · 2025: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Science of The Total Environment (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence nationale de la recherche (16-CE36-0007-01)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- solar radiation, allergen sensitization, childhood asthma, rhinitis, atopic dermatitis, maternal vitamin D supplementation, prenatal exposure
- MeSH terms
- Child, Environmental Exposure, Female, Humans, Hypersensitivity, Infant, Paris, Pregnancy, Sunlight, Vitamin D, Dietary Supplements
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