Cited by 3,724Asthma and respiratory diseasesAllergic Rhinitis and SensitizationOccupational exposure and asthma

International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods

Asher, MI, Keil, U, Anderson, HR, Beasley, R, Crane, J, Martinez, F, Mitchell, EA, Pearce, N +3 more·1995·European Respiratory Journal

Abstract

The aetiology of asthma and allergic disease remains poorly understood, despite considerable research. The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration. Its specific aims are: 1) to describe the prevalence and severity of asthma, rhinitis and eczema in children living in different centres, and to make comparisons within and between countries; 2) to obtain baseline measures for assessment of future trends in the prevalence and severity of these diseases; and 3) to provide a framework for further aetiological research into genetic, lifestyle, environmental, and medical care factors affecting these diseases. The ISAAC design comprises three phases. Phase 1 uses core questionnaires designed to assess the prevalence and severity of asthma and allergic disease in defined populations. Phase 2 will investigate possible aetiological factors, particularly those suggested by the findings of Phase 1. Phase 3 will be a repetition of Phase 1 to assess trends in prevalence.

Integrity signals

Registry

Crossref · 10.1183/09031936.95.08030483

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Large multinational studies in children and adults confirmed that asthma is one of the most common chronic diseases across the globe in all age groups and there is substantial variation in asthma prevalence worldwide.

    “These studies confirmed that asthma is one of the most common chronic diseases across the globe in all age groups and there is substantial variation in asthma prevalence worldwide.”

    From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [8]

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Authors
Asher, M., Keil, U., Anderson, H., Beasley, R., Crane, J., Martinez, F., Mitchell, E., Pearce, N., Sibbald, B., Stewart, A., & et, A.
Affiliations
University of Auckland (NZ)
Venue
European Respiratory Journal
Published
1995-03-01
Volume
8
Issue
3
Pages
483-491
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
OpenAlex
W2142010704
Cited by
3,724
References
57
Citations by year
2026: 94 · 2025: 127 · 2024: 151 · 2023: 164 · 2022: 149 · 2021: 207 · 2020: 144 · 2019: 140 · 2018: 154 · 2017: 129 · 2016: 141 · 2015: 178 · 2014: 190 · 2013: 162 · 2012: 164
FWCI
18.11
Type
journal article
Language
en
Open access
closed
Locations
European Respiratory Journal (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
asthma, allergic diseases, childhood asthma, rhinitis, atopic dermatitis, prevalence, disease severity, international cooperation, standardized questionnaires, etiology, prevalence trends, Isaac

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