International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods
Abstract
The aetiology of asthma and allergic disease remains poorly understood, despite considerable research. The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration. Its specific aims are: 1) to describe the prevalence and severity of asthma, rhinitis and eczema in children living in different centres, and to make comparisons within and between countries; 2) to obtain baseline measures for assessment of future trends in the prevalence and severity of these diseases; and 3) to provide a framework for further aetiological research into genetic, lifestyle, environmental, and medical care factors affecting these diseases. The ISAAC design comprises three phases. Phase 1 uses core questionnaires designed to assess the prevalence and severity of asthma and allergic disease in defined populations. Phase 2 will investigate possible aetiological factors, particularly those suggested by the findings of Phase 1. Phase 3 will be a repetition of Phase 1 to assess trends in prevalence.
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Large multinational studies in children and adults confirmed that asthma is one of the most common chronic diseases across the globe in all age groups and there is substantial variation in asthma prevalence worldwide.
“These studies confirmed that asthma is one of the most common chronic diseases across the globe in all age groups and there is substantial variation in asthma prevalence worldwide.”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [8]
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Self-citationOriginal article: Rhinoconjunctivitis in 5‐year‐old children: a population‐based birth cohort study
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“‘Current wheeze’ was defined as a positive answer to the question, ‘Has your child had wheezing or whistling in the chest in the last 12 months?’ [17] ‘Current asthma’ was defined as a positive answer to two out of three of: ‘Has the doctor ever told you that your child had asthma?’; ‘Has your child had wheezing or wh…”
BackgroundAsthma severity and atopy: how clear is the relationship?
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Fetal Exposure to Maternal and Paternal Smoking and the Risks of Wheezing in Preschool Children
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Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort
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Impact of rhinitis on asthma severity in school-age children
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Traffic pollution is associated with early childhood aeroallergen sensitization
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Tobacco Smoke Exposure, Airway Resistance, and Asthma in School-age Children
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The impact of temperature on the skin barrier and atopic dermatitis
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Prevalence and Allergen of Allergic Rhinitis in Korean Children
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Pets at birth do not increase allergic disease in at‐risk children
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Contact with livestock – a protective effect against allergies and asthma?
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Swimming pool attendance and respiratory symptoms and allergies among Dutch children
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Effects of Indoor Air Pollutants on Atopic Dermatitis
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The Prevalence of Atopic Dermatitis in Korean Children
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Factors associated with Allergic Rhinitis in Colombian subpopulations aged 1 to 17 and 18 to 59
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- Authors
- Asher, M., Keil, U., Anderson, H., Beasley, R., Crane, J., Martinez, F., Mitchell, E., Pearce, N., Sibbald, B., Stewart, A., & et, A.
- Affiliations
- University of Auckland (NZ)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1995-03-01
- Volume
- 8
- Issue
- 3
- Pages
- 483-491
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2142010704
- Cited by
- 3,724
- References
- 57
- Citations by year
- 2026: 94 · 2025: 127 · 2024: 151 · 2023: 164 · 2022: 149 · 2021: 207 · 2020: 144 · 2019: 140 · 2018: 154 · 2017: 129 · 2016: 141 · 2015: 178 · 2014: 190 · 2013: 162 · 2012: 164
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Respiratory Journal (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, allergic diseases, childhood asthma, rhinitis, atopic dermatitis, prevalence, disease severity, international cooperation, standardized questionnaires, etiology, prevalence trends, Isaac
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