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Cited by 70Vitamin D Research StudiesPharmacological Effects and Toxicity StudiesBone health and osteoporosis research

The effect of anti epileptic drug therapy on serum 25-hydroxyvitamin D and parameters of calcium and bone metabolism—A longitudinal study

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Menon, Bindu, Harinarayan, C.V.·2010·Seizure
DOI 10.1016/j.seizure.2010.01.006
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Abstract

Background Chronic antiepileptic drug use is associated with bone loss. We sought to assess the longitudinal effect of antiepileptic drug on serum 25-hydroxyvitamin D [25(OH)D] levels and bone mineral metabolism markers.Methods Patients in the emergency services or those in neurology outpatient department with history of seizure were characterized and included in the study prospectively. Daily dietary intake of calories, calcium, phosphorus and phytates were characterized by dietary recall method. Base line bone mineral parameters - serum calcium, phosphorus, alkaline phosphatase (SAP), tartrate resistant acid phosphatase (TRACP), 25(OH)D levels, parathyroid hormone (PTH) and urinary calcium creatinine ratio (Ca.Cr), urinary calcium/kg/bodyweight (BW) and phosphate excretion index (PEI) were determined. Patients on AED therapy with normal 25(OH)D levels were followed up and were re-evaluated at the end of 6 months.Results The daily dietary calcium intake of the subjects was lower than the RDA (Recommended Dietary Allowance) by ICMR (Indian Council of Medical Research). The diet was high in phytates. Two-thirds of the recruited subjects were vitamin D deficient. Subjects with normal 25(OH)D levels at base line showed a significant fall of 25(OH)D levels, urinary calcium, urinary calcium/kg/BW and TRACP levels at the end of 6 months irrespective of the AED used or the plasma level of AED.Conclusions Hypovitaminosis D is common in our population. Subjects with normal 25(OH)D levels, irrespective of the type of antiepileptic medications even at sub-therapeutic serum levels of the drug, went into 25(OH)D deficiency and insufficiency states. Theoretically it can be worthwhile to supplement calcium and vitamin D even before initiation of antiepileptic therapy.

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  • Inflammation, gastrointestinal issues, antiepileptic drugs and genetics are among factors affecting vitamin D metabolism or absorption.

    “Inflammation [120,121], gastrointestinal issues [123,124], antiepileptic drugs [125] and genetics are among these factors.”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [125]

  • These deficiencies can exacerbate the condition.

    “It should be noted that at the same time, antiepileptic drugs impair vitamin D and calcium metabolism, leading to reduced levels of vitamin D and calcium [125], and these deficiencies can, on the other hand, exacerbate the condition.”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [125]

  • Antiepileptic drugs impair vitamin D and calcium metabolism, leading to reduced levels of vitamin D and calcium.

    “It should be noted that at the same time, antiepileptic drugs impair vitamin D and calcium metabolism, leading to reduced levels of vitamin D and calcium [125], and these deficiencies can, on the other hand, exacerbate the condition.”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [125]

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Authors
Menon, B., & Harinarayan, C. V.
Affiliations
Sri Venkateswara Institute of Medical Sciences (IN)
Corresponding author
  • Menon, Bindu
  • Harinarayan, C.V.
ORCID
Venue
Seizure
Publisher
Elsevier BV
Published
2010-04
Volume
19
Issue
3
Pages
153-158
ISSN
1059-1311 (ISSN-L)
DOI
10.1016/j.seizure.2010.01.006
OpenAlex
W1974962456
Cited by
70
References
47
Citations by year
2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 2 · 2013: 9 · 2012: 1
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Seizure (publishedVersion)
  • PubMed (publishedVersion)
Funders
Indian Council of Medical Research
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
antiepileptic drugs, 25-hydroxyvitamin D, vitamin D deficiency, bone metabolism, bone loss, serum calcium, phosphorus, alkaline phosphatase, tartrate-resistant acid phosphatase, parathyroid hormone, urinary calcium, calcium intake, phytic acid, epilepsy, vitamin D supplementation
MeSH terms
Adolescent, Adult, Aged, Anticonvulsants, Bone and Bones, Calcium, Calcium, Dietary, Child, Diet, Female, Humans, Male, Middle Aged, Seizures, Vitamin D, Vitamin D Deficiency, Young Adult

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