Cognitive disorders in epilepsy I: Clinical experience, real-world evidence and recommendations
Open accessAbstract
This is the first of two narrative reviews on cognitive disorders in epilepsy (companion publication : Cognitive disorders in epilepsy II: Clinical targets, indications and selection of test instruments). Its focus is on clinical experience, real-world evidence, and clinical recommendations. Cognitive disorders are a common comorbidity in children and adults with epilepsy. These cognitive disturbances may preceed the onset of seizures and are multifactorial including contributions by pre-existing brain damage, seizures, interictal epileptic discharges, and treatments including medications and surgery. Comorbid cognitive impairments can have a negative impact on the quality of life in people with epilepsy. They are under-identified and frequently not treated. Comorbid psychiatric disorders, such as ADHD can also contribute to a worse cognitive performance and can benefit from pharmacotherapy with CNS stimulants. Likewise, mood disorders cause a subjective perception of poor memory and attention, which can be reversed with antidepressants of the SSRI family. This narrative review discusses these issues from a real-world clinical perspective in children and adults with newly diagnosed and chronic epilepsy. The need for further research to understand and treat these disorders is noted.
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Representations and algorithms in digital technologies can model how brain systems are organized and work, suggesting theoretical connections between neuroscience and digital technologies used in e-learning.
“For example, representations and algorithms in digital technologies can model how brain systems are organized and work, suggesting sound theoretical connections between neuroscience and digital technologies used in e-learning [119-122].”
From Leveraging AI in E-Learning: Personalized Learning and Adaptive Assessment through Cognitive Neuropsychology—A Systematic Analysis (2024) · cites this paper as [121]
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- Authors
- Kanner, A. M., Helmstaedter, C., Sadat-Hossieny, Z., & Meador, K.
- Affiliations
- University of Miami (US)
- University Hospital Bonn (DE)
- Stanford Medicine (US)
- Corresponding author
- Kanner, Andres M.
- Venue
- Seizure
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 83
- Pages
- 216-222
- ISSN
- 1059-1311 (ISSN-L)
- OpenAlex
- W3093464171
- Cited by
- 89
- References
- 60
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 23 · 2023: 15 · 2022: 11 · 2021: 7
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Seizure (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ational Institutes of Health and Sunovion Pharmaceuticals,
- EU Grant E-Epilepsy,
- piCare European Network (ERN),
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cognitive impairment, epilepsy, comorbidities, attention deficit hyperactivity disorder, mood disorders, antidepressants, selective serotonin reuptake inhibitors, psychostimulants, antiepileptic drugs, epilepsy surgery, interictal epileptiform discharges, quality of life, underdiagnosis
- MeSH terms
- Anticonvulsants, Cognition, Cognition Disorders, Epilepsy, Humans, Quality of Life, Seizures
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