Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Targeting HIF-1 for cancer therapy

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α

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CD133 glycosylation is enhanced by hypoxia in cultured glioma stem cells

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Artificial neural network classifier predicts neuroblastoma patients’ outcome

Cangelosi, D., Pelassa, S., Morini, M., Conte, M., Bosco, M. C., Eva, A., Sementa, A. R., & Varesio, L. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1194-3 · Cited by 42

Inhibition of miR-135b by SP-1 promotes hypoxia-induced vascular endothelial cell injury via HIF-1α

Yang, S., Yin, J. Y., & Hou, X. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.001 · Cited by 41

Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration

Offer, S., Menard, J. A., Pérez, J. E., de Oliveira, K. G., Chandran, V. I., Johansson, M. C., Bång-Rudenstam, A., Siesjö, P., Ebbesson, A., Hedenfalk, I. A., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1228-6 · Cited by 41

Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

Giaccia, A. J., & Schipani, E. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_73 · Cited by 43

Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets

Gore, M., Kabekkodu, S. P., & Chakrabarty, S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189292 · Cited by 41

Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells

Xu, Y., Han, S., Lei, K., Chang, X., Wang, K., Zhou, L., & Liu, J. (2015) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000205 · Cited by 39

A metabolic perspective of Peto's paradox and cancer

Dang, C. V. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0223 · Cited by 39

Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer

Ulivi, P., Marisi, G., & Passardi, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8712 · Cited by 40

Hif-1α/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker (Larimichthys crocea) under environmental hypoxia

Luo, S.-Y., 宁波大学海洋学院教育部应用海洋生物技术重点实验室, 浙. 宁. 3., Wang, J., Liu, C., Gao, X., Zhang, Y., Ding, J., Hou, C.-C., Zhu, J., Lou, B., et al. (2021) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2021.224 · Cited by 39

Glutathione peroxidase 8 is transcriptionally regulated by HIFα and modulates growth factor signaling in HeLa cells

Bosello-Travain, V., Forman, H. J., Roveri, A., Toppo, S., Ursini, F., Venerando, R., Warnecke, C., Zaccarin, M., & Maiorino, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.12.020 · Cited by 38

Hypoxia as a Cause of Treatment Failure in Non–Small Cell Carcinoma of the Lung

Brustugun, O. T. (2014) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2014.11.006 · Cited by 38

Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences

Yang, O. C. Y., Maxwell, P. H., & Pollard, P. J. (2013) · Kidney International · doi:10.1038/ki.2013.245 · Cited by 38

Normoxic accumulation of HIF1α is associated with glutaminolysis

Kappler, M., Pabst, U., Rot, S., Taubert, H. W., Wichmann, H., Schubert, J., Bache, M., Weinholdt, C., Immel, U., Große, I., et al. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1780-9 · Cited by 38

The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

Zhang, J., Zhang, Y., Mo, F., Patel, G., Butterworth, K. T., Shao, C., & Prise, K. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637454 · Cited by 38

Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer

Abreu, P. L., Ferreira, L. M. R., Alpoim, M. C., & Urbano, A. M. (2014) · BioMetals · doi:10.1007/s10534-014-9726-7 · Cited by 39

Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1–S cell cycle transition in radioresistance of perinecrotic tumor cells

Zhu, Y., Zhao, T., Itasaka, S., Li, Z., Yeom, C. J., Hirota, K., Suzuki, K., Morinibu, A., Shinomiya, K., Ou, G., et al. (2012) · Oncogene · doi:10.1038/onc.2012.223 · Cited by 38

In Vivo Imaging of HIF-Active Tumors by an Oxygen-Dependent Degradation Protein Probe with an Interchangeable Labeling System

Kuchimaru, T., Kadonosono, T., Tanaka, S., Ushiki, T., Hiraoka, M., & Kizaka‐Kondoh, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015736 · Cited by 37

Metabolic Reprogramming in Cancer: Role of HPV 16 Variants

Arizmendi-Izazaga, A., Navarro‐Tito, N., Jiménez‐Wences, H., Catalán, M. A. M., Martínez-Carrillo, D. N., Zacapala-Gómez, A. E., Olea‐Flores, M., Dircio-Maldonado, R., Torres‐Rojas, F. I., Soto-Flores, D. G., et al. (2021) · Pathogens · doi:10.3390/pathogens10030347 · Cited by 37

Acute responses of brown mussel (Perna perna) exposed to sub-lethal copper levels: Integration of physiological and cellular responses

Vosloo, D., Sara, J. R., & Vosloo, A. (2011) · Aquatic Toxicology · doi:10.1016/j.aquatox.2011.10.001 · Cited by 37

Noninvasive Multiparametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft

Penet, M., Pathak, A. P., Raman, V., Ballesteros, P., Artemov, D., & Bhujwalla, Z. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1782 · Cited by 37

Manipulation of Glycolysis in Malignant Tumors: Fantasy or Therapy?

Sattler, U. G. A., Hirschhaeuser, F., & Mueller-Klieser, W. (2009) · Current Medicinal Chemistry · doi:10.2174/092986710790112657 · Cited by 37

Metabolic pathways fueling the suppressive activity of myeloid-derived suppressor cells

Goldmann, O., & Medina, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1461455 · Cited by 42

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells

Bock, K. D., Smet, F. D., de Oliveira, R. L., Anthonis, K., & Carmeliet, P. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0482-z · Cited by 39

Transforming growth factor‐β signaling enhancement by long‐term exposure to hypoxia in a tumor microenvironment composed of L ewis lung carcinoma cells

Furuta, C., Miyamoto, T., Takagi, T., Noguchi, Y., Kaneko, J., Itoh, S., Watanabe, T., & Itoh, F. (2015) · Cancer Science · doi:10.1111/cas.12773 · Cited by 37

Revisiting the Warburg effect in cancer cells with proteomics. The emergence of new approaches to diagnosis, prognosis and therapy

Scatena, R., Bottoni, P., Pontoglio, A., & Giardina, B. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900157 · Cited by 36

Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro

Maugeri, G., D’Amico, A. G., Reitano, R., Saccone, S., Federico, C., Cavallaro, S., & D’Agata, V. (2016) · Cell and Tissue Research · doi:10.1007/s00441-015-2340-3 · Cited by 35

Asparagus Polysaccharide inhibits the Hypoxia-induced migration, invasion and angiogenesis of Hepatocellular Carcinoma Cells partly through regulating HIF1α/VEGF expression via MAPK and PI3K signaling pathway

Cheng, W., Cheng, Z., Weng, L., Xing, D., & Zhang, M. (2021) · Journal of Cancer · doi:10.7150/jca.51407 · Cited by 36

Overexpression of factor inhibiting HIF‐1 enhances vessel maturation and tumor growth via platelet‐derived growth factor‐C

Kuzmanov, A., Wielockx, B., Rezaei, M., Kettelhake, A., & Breier, G. (2011) · International Journal of Cancer · doi:10.1002/ijc.27360 · Cited by 36

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development

Mangiavini, L., Merceron, C., Araldi, E., Khatri, R., Gerard-O’Riley, R. L., Wilson, T. L., Rankin, E. B., Giaccia, A. J., & Schipani, E. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.06.013 · Cited by 36

Reactive oxygen species in BCR-ABL1-expressing cells – relevance to chronic myeloid leukemia

Antoszewska-Smith, J., Pawłowska, E., & Błasiak, J. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1396 · Cited by 36

The Mechanisms of Regulation of Aerobic Glycolysis (Warburg Effect) by Oncoproteins in Carcinogenesis

Kobliakov, V. A. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919100018 · Cited by 34

Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients

Cangelosi, D., Blengio, F., Versteeg, R., Eggert, A., Garaventa, A., Gambini, C., Conte, M., Eva, A., Muselli, M., & Varesio, L. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-s7-s12 · Cited by 34

Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment

Logghe, T., van Zwol, E., Immordino, B., den Cruys, K. V., Peeters, M., Giovannetti, E., & Bogers, J. (2024) · Cancers · doi:10.3390/cancers16030505 · Cited by 37

The Diverse Roles of Histone Demethylase KDM4B in Normal and Cancer Development and Progression

Wang, Z., Cai, H., Zhao, E., & Cui, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790129 · Cited by 33

Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase

Liu, Q., Geng, H., Xue, C., Beer, T. M., & Qian, D. Z. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.011 · Cited by 32

Differential response to exercise in claudin-low breast cancer

Glass, O. K., Bowie, M., Fuller, J., Darr, D., Usary, J., Boss, K., Choudhury, K. R., Liu, X., Zhang, Z., Locasale, J. W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21054 · Cited by 32

Blue-Print Autophagy: Potential for Cancer Treatment

Ruocco, N., Costantini, S., & Costantini, M. (2016) · Marine Drugs · doi:10.3390/md14070138 · Cited by 33

Hypoxia-induced PGC-1α Regulates Mitochondrial Function and Tumorigenesis of Colorectal Cancer Cells

Yun, C. W., Lee, J. H., & Lee, S. H. (2019) · Anticancer Research · doi:10.21873/anticanres.13672 · Cited by 32

Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress

Sasaki, Y., Takagane, K., Konno, T., Itoh, G., Kuriyama, S., Yanagihara, K., Yashiro, M., Yamada, S., Murakami, S., & Tanaka, M. (2021) · Cancer Science · doi:10.1111/cas.14794 · Cited by 33

HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development

Dzhalilova, D. S., & Makarova, O. V. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921100011 · Cited by 34

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients

Cangelosi, D., Muselli, M., Parodi, S., Blengio, F., Becherini, P., Versteeg, R., Conte, M., & Varesio, L. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-s5-s4 · Cited by 32

Paris saponin H inhibits the proliferation of glioma cells through the A1 and A3 adenosine receptor‑mediated pathway

Bi, L., Yang, L., Yang, Q., Zhou, X., Li, H., Yang, L., Li, J., Lu, Y., & Tang, H. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4863 · Cited by 31

Hypoxia Promotes CEMP1 Expression and Induces Cementoblastic Differentiation of Human Dental Stem Cells in an HIF-1-Dependent Manner

Choi, H., Hexiu, J., Kim, J., Lim, K., Choung, H., Park, J., Chung, J. H., & Choung, P. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0132 · Cited by 31

Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells

Flores, R. E., Brown, A. K., Taus, L. J., Khoury, J., Glover, F., Kami, K., Sarangarajan, R., Walshe, T. E., Narain, N. R., Kiebish, M. A., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.03.012 · Cited by 31

Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

van Gisbergen, M. W., Offermans, K., Voets, A. M., Lieuwes, N. G., Biemans, R., Hoffmann, R. F., Dubois, L. J., & Lambin, P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00770 · Cited by 30

Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells

Lee, H., Jung, D., Sohn, E. J., Kim, H. H., Park, M. N., Lew, J.-H., Lee, S., Kim, B., & Kim, S. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/390957 · Cited by 30

1H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism

Čuperlović‐Culf, M., Cormier, K., Touaibia, M., Reyjal, J., Robichaud, S., Belbraouet, M., & Turcotte, S. (2015) · International Journal of Cancer · doi:10.1002/ijc.29947 · Cited by 31

Myristica fragransSuppresses Tumor Growth and Metabolism by Inhibiting Lactate Dehydrogenase A

Kim, E.-Y., Choi, H., Park, M.-J., Jung, Y.-S., Lee, S., Kim, K., Choi, J., Chung, T., & Ha, K. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500592 · Cited by 30

Targeting Pivotal Hallmarks of Cancer for Enhanced Therapeutic Strategies in Triple-Negative Breast Cancer Treatment—In Vitro, In Vivo and Clinical Trials Literature Review

Szulc, A., & Woźniak, M. (2024) · Cancers · doi:10.3390/cancers16081483 · Cited by 32

Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer

Durán, R., Mirpour, S., Pekurovsky, V., Ganapathy‐Kanniappan, S., Brayton, C. F., Cornish, T. C., Gorodetski, B., Reyes, J., Chapiro, J., Schernthaner, R. E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0725 · Cited by 29

Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism

Eyassu, F., & Angione, C. (2017) · Royal Society Open Science · doi:10.1098/rsos.170360 · Cited by 30

Expression levels of miR-143-3p and -424-5p in colorectal cancer and their clinical significance

Sahami-Fard, M. H., Kheirandish, S., & Sheikhha, M. H. (2019) · Cancer Biomarkers · doi:10.3233/cbm-182171 · Cited by 29

Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors

Sasajima, J., Mizukami, Y., Sugiyama, Y., Nakamura, K., Kawamoto, T., Koizumi, K., Fujii, R., Motomura, W., Sato, K., Suzuki, Y., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0412 · Cited by 29

A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells

Kim, D. H., Hossain, M. A., KIM, M. Y., KIM, J.-A., Yoon, J.-H., Suh, H. S., Kim, G., Choi, Y. H., Chung, H. Y., & Kim, N. D. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2116 · Cited by 29

Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy

She, W., Liu, T., Li, H., Wang, Z., Guo, Z., Liu, Y., & Liu, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01197 · Cited by 28

Long non-coding RNA-based glycolysis-targeted cancer therapy: feasibility, progression and limitations

Liu, R., Wang, X., Shen, Y., & He, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06247-7 · Cited by 28

The Ketogenic Diet in Colorectal Cancer: A Means to an End

Tamraz, M., Ghossaini, N. A., & Temraz, S. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043683 · Cited by 28

Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

Quaegebeur, A., & Carmeliet, P. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_83 · Cited by 27

The Glycolytic Phenotype is Correlated with Aggressiveness and Poor Prognosis in Invasive Ductal Carcinomas

Jang, S. M., Han, H., Jang, K.-S., Jun, Y. J., Jang, S., Min, K., Chung, M. S., & Paik, S. S. (2012) · Journal of Breast Cancer · doi:10.4048/jbc.2012.15.2.172 · Cited by 28

Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq

Chen, X., Yang, M. Y., Hao, W., Han, J., Ma, J., Wang, C., Sun, S., & Zheng, Q. (2016) · Gene · doi:10.1016/j.gene.2016.07.052 · Cited by 28

Fueled by microtubules: Does tubulin dimer/polymer partitioning regulate intracellular metabolism?

Cassimeris, L., Silva, V. C., Miller, E., Ton, Q. V., Molnar, C. A., & Fong, J. T. (2012) · Cytoskeleton · doi:10.1002/cm.21008 · Cited by 30

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Jones, D. T., Valli, A., Haider, S. A., Zhang, Q., Smethurst, E. A., Schug, Z. T., Peck, B., Aboagye, E. O., Critchlow, S. E., Schulze, A., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0857 · Cited by 26

Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma

Smeland, E., Kilvaer, T. K., Sørbye, S. W., Valkov, A., Andersen, S., Bremnes, R. M., Busund, L., & Dønnem, T. (2012) · Sarcoma · doi:10.1155/2012/541650 · Cited by 27

Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing

Zhang, X., Zhang, W., Ma, S., Miasniakova, G., Sergueeva, A., Ammosova, T., Xu, M., Nekhai, S. A., Nourai, M., Wade, M. S., et al. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.07.016 · Cited by 26

Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α

Zhang, Q., Qin, Y., Sun, X., Bian, Z., Liu, H., Liu, H., Mao, L., & Sun, S. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111227 · Cited by 33

Hypoxia-inducible-factor-1 in trauma and critical care

Bogdanovski, D. A., DiFazio, L. T., Bogdanovski, A. K., Csóka, B., Jordan, G. B., Paul, E. R., Antonioli, L., Pilip, S. A., & Németh, Z. H. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.07.029 · Cited by 26

Forchlorfenuron Disrupts SEPT9_i1 Filaments and Inhibits HIF-1

Vardi‐Oknin, D., Golan, M., & Mabjeesh, N. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073179 · Cited by 26

Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the Development of Innovative Radiation Therapy

Yeom, C. J., Zeng, L., Zhu, Y., Hiraoka, M., & Harada, H. (2011) · Cancers · doi:10.3390/cancers3033610 · Cited by 26

Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines

Straud, S., Zubovych, I. O., Brabander, J. K. D., & Roth, M. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011629 · Cited by 26

Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism

Wan, X., Liu, Y., Zhao, Y., Sun, X., Fan, D., & Guo, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184213 · Cited by 27

Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts

Kokkonen, N., Khosrowabadi, E., Hassinen, A., Harrus, D., Glumoff, T., Kietzmann, T., & Kellokumpu, S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7389 · Cited by 26

The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation

Manley, S., Liu, W., & Welch, D. R. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1552-2 · Cited by 26

Bioactive food components, cancer cell growth limitation and reversal of glycolytic metabolism

Keijer, J., Bekkenkamp‐Grovenstein, M., Venema, D. P., & Dommels, Y. E. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.08.007 · Cited by 25

The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen

Fox, S. B., Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2011) · Breast Cancer Research · doi:10.1186/bcr2825 · Cited by 24

The estrogen-related receptors in metabolism and cancer: newer insights

Ranhotra, H. S. (2018) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2018.1456552 · Cited by 24

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Combined therapies of antithrombotics and antioxidants delayin silicobrain tumour progression

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Regulation of Glucose Metabolism in Hepatocarcinogenesis by MicroRNAs

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Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma

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Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

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Metabolic Alterations During the Growth of Tumour Spheroids

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Novel insights into the role of hypoxia-inducible factor-1 in the pathogenesis of human post-intubation tracheal stenosis

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Cyclic Distraction–Compression Dynamization Technique Enhances the Bone Formation During Distraction Osteogenesis

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Regulation of Hypoxia Dependent Reprogramming of Cancer Metabolism: Role of HIF-1 and Its Potential Therapeutic Implications in Leukemia

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