Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
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Antineoplastic drugs that target the VEGF pathway have emerged as inducers of hypertension in patients being treated for malignancies.
“In patients being treated for malignancies, antineoplastic drugs that target the VEGF (vascular endothelial growth factor) pathway have emerged as inducers of hypertension.225–227”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [225]
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- Authors
- Ferrara, N., Hillan, K. J., Gerber, H.-P., & Novotny, W.
- Affiliations
- Genentech (US)
- Corresponding author
- Ferrara, Napoleone
- Venue
- Nature Reviews Drug Discovery
- Published
- 2004-05-01
- Volume
- 3
- Issue
- 5
- Pages
- 391-400
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1539571840
- Semantic Scholar
- b49795dfc6a855137bcd5454c47c7cc07eae9a1e
- Cited by
- 2,625
- References
- 161
- Citations by year
- 2026: 71 · 2025: 84 · 2024: 93 · 2023: 117 · 2022: 93 · 2021: 118 · 2020: 118 · 2019: 115 · 2018: 100 · 2017: 101 · 2016: 130 · 2015: 126 · 2014: 148 · 2013: 174 · 2012: 150
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- bevacizumab, anti-VEGF antibody, vascular endothelial growth factor, tumor angiogenesis, anti-angiogenic therapy, metastatic colorectal cancer, monoclonal antibodies, humanized monoclonal antibody, drug development history
- MeSH terms
- Bevacizumab, Animals, Antibodies, Monoclonal, Drug Administration Schedule, Humans, Colorectal Neoplasms, Survival Analysis, Randomized Controlled Trials as Topic, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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