From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

Efferth, Thomas·2017·Seminars in Cancer Biology
DOI 10.1016/j.semcancer.2017.02.009

Cites (261)

Items 201–261 of 261

  1. Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin
    Yan Yang, Xiaomin Zhang, Xiaofen Wang, Xiaomei Zhao, Tianrui Ren, Feng Wang, Bo Yu · 2014 · International Journal of Pharmaceutics
  2. DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal
    Hong Zhu, Sida Liao, Jia-Jie Shi, Lin-Lin Chang, Yunguang Tong, Ji Cao, Yingying Fu, Xiuping Chen, Meidan Ying, Bo Yang et al. · 2014 · Free Radical Biology and Medicine
  3. Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy
    Dieter Lemke, Hans-Werner Pledl, Markus Zorn, Manfred Jugold, Ed Green, Jonas Blaes, Sarah Löw, Anne Hertenstein, Martina Ott, Felix Sahm et al. · 2016 · Oncotarget
  4. Effects of artemisinin antimalarials on Cytochrome P450 enzymesin vitrousing recombinant enzymes and human liver microsomes: potential implications for combination therapies
    Therese Ericsson, Jesper Sundell, Angelica Torkelsson · 2014 · Xenobiotica
  5. From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria
    Ushma S. Neill · 2011 · Journal of Clinical Investigation
  6. Dihydroartemisinin Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in HepG2 Human Hepatoma Cells
    Xiaoling Gao, Ziguo Luo, Tingxiu Xiang, Kejian Wang, Jian Li, Pilong Wang · 2011 · Tumori Journal
  7. Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71
    Fei Linda Zhao, HAN WANG, PATRICILIA KUNDA, Xuemei Chen, QIU-LING LIU, TAO LIU · 2013 · Oncology Reports
  8. Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma
    Shunqin Zhu, Wanhong Liu, Xiaoxue Ke · 2014 · Oncology Reports
  9. Erratum to: Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study
    Miriam König, Cornelia von Hagens, S. Hoth · 2016 · Cancer Chemotherapy and Pharmacology
  10. Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion
    Xiuhua Wu, Huijun Zhou, Jun Hyung Lee · 2006 · Anti-Cancer Drugs
  11. A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine
    Richard Kingston Haynes, Kwan‐Wing Cheu, Ka‐Yan Li · 2011 · ChemMedChem
  12. Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells.
    Xiaoling Gao, Ziguo Luo, Tingxiu Xiang, Kejian Wang, Jian Li, Wang Pi-long · 2011 · Tumori
  13. Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells
    Dezhi Mu, Hui Min Qi, Wei Chen · 2007 · Methods and Findings in Experimental and Clinical Pharmacology
  14. Inhibitive Effect of Artemether on Tumor Growth and Angiogenesis in the Rat C6 Orthotopic Brain Gliomas Model
    Zhiping Wu, Cheng-wei Gao, Yong-gui Wu · 2009 · Integrative Cancer Therapies
  15. Translationally Controlled Tumor Protein Is a Novel Biological Target for Neurofibromatosis Type 1-associated Tumors
    Daiki Kobayashi, Mio Hirayama, Yoshihiro Komohara, Souhei Mizuguchi, Masayo Wilson‐Morifuji, Hironobu Ihn, Motohiro Takeya, Akira Kuramochi, Norie Araki · 2014 · Journal of Biological Chemistry
  16. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua
    Elmar Breuer, Thomas Efferth · 2014 · Natural Products and Bioprospecting
  17. Effect of artesunate on immune cells in ret-transgenic mouse melanoma model
    Marcel Ramacher, Viktor Umansky, Thomas Efferth · 2009 · Anti-Cancer Drugs
  18. Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase
    Qing-Ping Zeng, Ping-Zu Zhang · 2010 · Nitric Oxide
  19. Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumor model evaluated by conventional methods and optical imaging.
    Winn Aung, Chizuru Sogawa, Takako Furukawa · 2011 · PubMed
  20. Mechanism of dihydroartemisinin-induced apoptosis in prostate cancer PC3 cells: An iTRAQ-based proteomic analysis
    Ge Xu, Wen-Qin Zou, Shijuan Du, Mingjun Wu, Tingxiu Xiang, Ziguo Luo · 2016 · Life Sciences
  21. Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network
    Yilong Li, Yongwei Wang, Rui Kong, Dongbo Xue, Shangha Pan, Hua Chen, Bei Sun · 2016 · Oncotarget
  22. Artesunate attenuates glioma proliferation, migration and invasion by affecting cellular mechanical properties
    Shizhong Lian, Ruyi Shi, Xun Huang, Xiaoling Hu, Bin Song, Yinshan Bai, Bin Juan Yang, Jinyao Dong, Zhi-jie Du, Yanyan Zhang et al. · 2016 · Oncology Reports
  23. High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism
    Amit Subedi, Yushi Futamura, Mayuko Nishi, Akihide Ryo, Nobumoto Watanabe, Hiroyuki Osada · 2016 · Biochemical and Biophysical Research Communications
  24. Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction
    Chao Huang, Qian Ba, Qing‐Xi Yue · 2013 · Molecular BioSystems
  25. Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
    Liu Cao, Wangsheng Duanmu, Yi Yin et al. · 2014 · Die Pharmazie
  26. Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line
    Shokoofe Noori, Zuhair Muhammad Hassan, Vida Farsam · 2013 · Chinese Journal of Integrative Medicine
  27. Biological activity of dihydroartemisinin in canine osteosarcoma cell lines
    Kenji Hosoya, Sridhar Murahari, Albert Laio · 2008 · American Journal of Veterinary Research
  28. Artemisinin inhibits gastric cancer cell proliferation through upregulation of p53
    Hongtao Zhang, Yunlong Wang, Jie Zhang · 2013 · Tumor Biology
  29. Artesunate altered cellular mechanical properties leading to deregulation of cell proliferation and migration in esophageal squamous cell carcinoma
    RUYI SHI, Heyang Cui, Yanghui Bi, Xun Huang, Bin Song, Caixia Cheng, Ling Zhang, JING LIU, Chanting He, Fang Wang et al. · 2015 · Oncology Letters
  30. Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells
    Qiuyan Wang, Shao-Ling Wu, Xindong Zhao · 2015 · PLoS ONE
  31. Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature
    Martin Uhl, Stefan Schwab, Thomas Efferth · 2016 · Frontiers in Oncology
  32. Growth inhibitory effect of dihydroartemisinin on Bcr/Abl+ chronic myeloid leukemia K562 cells involve AKT, ERK and NF-κB modulation
    Jun Hyung Lee, Guobing Zhang, Xiuhua Wu · 2012 · Journal of Cancer Research and Clinical Oncology
  33. The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu.
    Youyou Tu · 2004 · PubMed
  34. Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line
    Jin‐Jian Lu, Si-Meng Chen, Jian Ding · 2011 · Molecular and Cellular Biochemistry
  35. Quantitative structure-activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1.
    Mohamed E.M. Saeed, Onat Kadioglu, Ean‐Jeong Seo · 2015 · PubMed
  36. Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages
    Hyung Gyun Kim, Ji Hye Yang, Eun Hee Han, Jae Ho Choi, Tilak Khanal, Myung Ho Jeong, Tae Cheon Jeong, Hye Gwang Jeong · 2013 · Food and Chemical Toxicology
  37. Therapeutic effects of dihydroartemisinin and transferrin against glioblastoma
    Suk Hee Kim, Seong Hee Kang, Bo Sun Kang · 2016 · Nutrition Research and Practice
  38. Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria
    Rachel Isba, Babalwa Zani, Michael Gathu · 2015 · Cochrane Database of Systematic Reviews
  39. Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
    Ivani Aquino, Marcela Stefanini Ferreira Tsuboy, Juliana Cristina Marcarini, Mário Sérgio Mantovani, Fábio Ferreira Perazzo, Edson Luis Maistro · 2013 · Genetics and Molecular Research
  40. Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells
    Tolga Eichhorn, Siegfried Schloissnig, Bettina Hahn · 2012 · Molecular BioSystems
  41. Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway
    Jiao Zhang, Ling Guo, Xia Zhou · 2016 · Oncology Letters
  42. Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway
    Haiying Hui, Na Wu, Min Wu · 2015 · Anti-Cancer Drugs
  43. Lysosomal accumulation of 67Ga-transferrin in malignant tumors in relation to their growth rate
    E. Aulbert, W. Disselhoff, H. Sörje · 1980 · European Journal of Cancer (1965)
  44. Comparison of High-Dose Intermittent and Low-Dose Continuous Oral Artemisinin in Dogs With Naturally Occurring Tumors
    Kenji Hosoya, C. Guillermo Couto, Cheryl A. London · 2014 · Journal of the American Animal Hospital Association
  45. Cytotoxicity of dihydroartemisinin toward Molt-4 cells attenuated by N-tert-butyl-alpha-phenylnitrone and deferoxamine.
    Andy Ho Wing Chan, Narendra Prasad Singh, Henry C. Lai · 2013 · PubMed
  46. Effects of antioxidants and pro-oxidants on cytotoxicity of dihydroartemisinin to Molt-4 human leukemia cells.
    Thomas E. Gerhardt, Ross Jones, Jungsoo Park · 2015 · PubMed
  47. Artesunate inhibits cell proliferation and decreases growth hormone synthesis and secretion in GH3 cells
    Zhi-gang Mao, Jing Zhou, Hui Wang, Dong-sheng He, Weiwei Xiao, Gui-zhi Liao, Lu-bin Qiu, Yong-hong Zhu, Hai-jun Wang · 2012 · Molecular Biology Reports
  48. A systematic review of the efficacy of a single dose artemisinin–naphthoquine in treating uncomplicated malaria
    Cho Min Naing, Maxine Anne Whittaker, Joon Wah Mak, Kyan Aung · 2015 · Malaria Journal
  49. Biochemical and Haematological Evaluation of Repeated Dose Exposure of Male Wistar Rats to an Ethanolic Extract of Artemisia annua
    Mbeh Ubana Eteng, Amos Olalekan Abolaji, Patrick Ekong Ebong, Ebiamadon Andi Brisibe, Ahsana Dar, Nurul Kabir, Muhammad Iqbal Choudhary · 2012 · Phytotherapy Research
  50. Dihydroartemisinin inhibits the Bcr/Abl oncogene at the mRNA level in chronic myeloid leukemia sensitive or resistant to imatinib
    Jun Hyung Lee, Peiqiang Shen, Guobing Zhang, Xiuhua Wu, Xingguo Zhang · 2012 · Biomedicine & Pharmacotherapy
  51. Differential interactions of the broad spectrum drugs artemisinin, dihydroartemisinin and artesunate with serum albumin
    Anbazhagan Veerappan, Tolga Eichhorn, Maen Zeino · 2013 · Phytomedicine
  52. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway
    Na Xu, Xuan Zhou, Shuang Wang · 2015 · International Journal of Medical Sciences
  53. Targeted Efficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model
    Lianke Liu, Hengfang Wu, Zhirui Guo · 2014 · Asian Pacific Journal of Cancer Prevention
  54. Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells
    Guoqing Luo, Zhenhe Huang, Xueqin Huang · 2016 · Journal of Cancer Research and Therapeutics
  55. [The constituents of young Artemisia annua].
    Y Y Tu · 1985 · PubMed
  56. Dihydroarteminsin-Induced Apoptosis is not Dependent on the Translocation of Bim to the Endoplasmic Reticulum in Human Lung Adenocarcinoma Cells
    Min Chen, Tongsheng Chen, Yingying Lü · 2012 · Pathology & Oncology Research
  57. Effect and mechanism of dihydroartemisinin on proliferation, metastasis and apoptosis of human osteosarcoma cells.
    Can Tang, P Y Ao, Zhao Yq · 2016 · PubMed
  58. DNA damage in dihydroartemisinin-resistant Molt-4 cells.
    Jungsoo Park, Henry C. Lai, Tomikazu Sasaki · 2015 · PubMed
  59. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling
    Wei-Qiang Tan, Gang Chen, Bing Jia · 2014 · Die Pharmazie
  60. Answer to the comment of Hai Lu et al. regarding “Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report and review of the literature. Arch Toxicol (2016)”
    Thomas Efferth, Ursula Schöttler, Sanjeev Krishna · 2017 · Archives of Toxicology
  61. Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82
    Seishiro Chikazawa, Yasunori KITAHARA, Erika Ando, Yasutomo Hori, Fumio Hoshi, Kazutaka Kanai, Naoyuki Ito, Seiichi Higuchi · 2013 · Journal of Veterinary Medical Science