From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

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Artemisinins target the SERCA of Plasmodium falciparum

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Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

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Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy

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The anti-malarial artesunate is also active against cancer

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A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides

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From traditional Chinese medicine to rational cancer therapy

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Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

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The Antiviral Activities of Artemisinin and Artesunate

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Artemisinins: Pharmacological actions beyond anti-malarial

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Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data

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Artemisinin: Discovery from the Chinese Herbal Garden

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Molecular Modes of Action of Artesunate in Tumor Cell Lines

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Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

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Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase ofPlasmodium falciparum

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Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

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Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells

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Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

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Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

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Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells

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Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

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Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

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The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin

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Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells

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Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells

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Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

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Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action

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Toxicity of the antimalarial artemisinin and its dervatives

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Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

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Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate

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Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro

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Artemisinin induces apoptosis in human cancer cells.

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A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer

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Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair

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Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

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Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin

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The molecular programme of tumour reversion: the steps beyond malignant transformation

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Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells

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Artesunate in the treatment of metastatic uveal melanoma - first experiences

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Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin

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Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy

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Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

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Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

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Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

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Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

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Dihydroartemisinin Is Cytotoxic to Papillomavirus-Expressing Epithelial Cells In vitro and In vivo

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Dihydroartemisinin is an inhibitor of ovarian cancer cell growth

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Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

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Cytotoxic Terpenoids and Flavonoids from<i>Artemisia annua</i>

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Treatment of first relapse in acute promyelocytic leukaemia with all-trans retinoic acid

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Transferrin receptor-dependent cytotoxicity of artemisinin–transferrin conjugates on prostate cancer cells and induction of apoptosis

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Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells

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Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation

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mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether

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Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells

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Inhibitory Effects of Artesunate on Angiogenesis and on Expressions of Vascular Endothelial Growth Factor and VEGF Receptor KDR/flk-1

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Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin

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Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins

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Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo

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Antimalarial dihydroartemisinin also inhibits angiogenesis

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Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling

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Novel surface antigen expressed on dividing cells but absent from nondividing cells.

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First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

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Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat

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Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/β‐catenin pathway

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The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

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Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

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Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial

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Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate

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Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

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TPT1/ TCTP-regulated pathways in phenotypic reprogramming

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Dihydroartemisinin Ameliorates Inflammatory Disease by Its Reciprocal Effects on Th and Regulatory T Cell Function via Modulating the Mammalian Target of Rapamycin Pathway

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Role of Transferrin Receptor and the ABC Transporters ABCB6 and ABCB7 for Resistance and Differentiation of Tumor Cells towards Artesunate

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First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers.

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Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines

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Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

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Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells

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Effects of artemisinin-tagged holotransferrin on cancer cells

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Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs.

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