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Cited by 27

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Explaining the dynamics of tumor aggressiveness: At the crossroads between biology, artificial intelligence and complex systems

La Porta, Caterina A.M., Zapperi, Stefano·2018·Seminars in Cancer Biology
DOI 10.1016/j.semcancer.2018.07.003
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Abstract

Facing metastasis is the most pressing challenge of cancer research. In this review, we discuss recent advances in understanding phenotypic plasticity of cancer cells, highlighting the kinetics of cancer stem cell and the role of the epithelial mesenchymal transition for metastasis. It appears that the tumor micro-environment plays a crucial role in triggering phenotypic transitions, as we illustrate discussing the challenges posed by macrophages and cancer associated fibroblasts. To disentangle the complexity of environmentally induced phenotypic transitions, there is a growing need for novel advanced algorithms as those proposed in our recent work combining single cell data analysis and numerical simulations of gene regulatory networks. We conclude discussing recent developments in artificial intelligence and its applications to personalized cancer treatment.

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Cited by

Metadata

Authors
La Porta, C. A. M., & Zapperi, S.
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2018-12
Volume
53
Pages
42-47
ISSN
1044-579X
DOI
10.1016/j.semcancer.2018.07.003
Cited by
27
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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