Tumor-associated macrophages: from basic research to clinical application

Immunity, Inflammation, and Cancer

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Microenvironmental regulation of tumor progression and metastasis

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Macrophage Diversity Enhances Tumor Progression and Metastasis

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The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

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Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

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The cellular and molecular origin of tumor-associated macrophages

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CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

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Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

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Macrophage Regulation of Tumor Responses to Anticancer Therapies

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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

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The impact of the extracellular matrix on inflammation

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Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

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The effects of β-glucan on human immune and cancer cells

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Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

Nywening, T. M., Wang‐Gillam, A., Sanford, D. E., Belt, B. A., Panni, R. Z., Cusworth, B. M., Toriola, A. T., Nieman, R., Worley, L. A., Yano, M., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)00078-4 · Cited by 818 · see citing works

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

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A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

Su, S., Liu, Q., Chen, J., Chen, J., Chen, F., He, C., Huang, D., Wu, W., Lin, L., Huang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.021 · Cited by 775 · see citing works

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionPreprint

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Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

Song, M., Liu, T., Shi, C., Zhang, X., & Chen, X. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b06779 · Cited by 664 · see citing works

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

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CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

Chen, J., Yao, Y., Gong, C., Yu, F., Su, S., Chen, J., Liu, B., Deng, H., Wang, F., Lin, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.006 · Cited by 645 · see citing works

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

Mazzieri, R., Pucci, F., Moi, D., Zonari, E., Ranghetti, A., Berti, A., Politi, L. S., Gentner, B., Brown, J. L., Naldini, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.005 · Cited by 639 · see citing works

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

Sanford, D. E., Belt, B. A., Panni, R. Z., Mayer, A., Deshpande, A. D., Carpenter, D. H., Mitchem, J. B., Plambeck-Suess, S. M., Worley, L. A., Goetz, B. D., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0525 · Cited by 619 · see citing works

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

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Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

Chen, Y., Zhang, S., Wang, Q., & Zhang, X. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0408-0 · Cited by 481 · see citing works

Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages

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Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

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The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer

Greten, F. R. (2003) · Cancer Letters · doi:10.1016/j.canlet.2003.08.029 · Cited by 410 · see citing works

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

Lu, T., Ramakrishnan, R., Altiok, S., Youn, J. I., Cheng, P., Celis, E., Писарев, В. М., Sherman, S., Sporn, M. B., & Gabrilovich, D. I. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45862 · Cited by 365 · see citing works

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

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The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression

Sánchez-Martı́n, L., Estecha, A., Samaniego, R., Sánchez‐Ramón, S., Vega, M. A., & Sánchez‐Mateos, P. (2010) · Blood · doi:10.1182/blood-2009-12-258186 · Cited by 322 · see citing works

A Novel Small Molecule Inhibitor of Signal Transducers and Activators of Transcription 3 Reverses Immune Tolerance in Malignant Glioma Patients

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Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

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Anti-inflammatory Properties of the Novel Antitumor Agent Yondelis (Trabectedin): Inhibition of Macrophage Differentiation and Cytokine Production

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Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

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A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

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Circulating giant macrophages as a potential biomarker of solid tumors

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Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment

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Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

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Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

Tripathi, C., Tewari, B. N., Kanchan, R. K., Baghel, K. S., Nautiyal, N., Shrivastava, R., Kaur, H., Bhatt, M. L. B., & Bhadauria, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2110 · Cited by 223 · see citing works

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study

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Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

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Vascular endothelial growth factor‐induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

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Is CD47 an innate immune checkpoint for tumor evasion?

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Control of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor

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Tumor associated macrophage expressing CD 204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma

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Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies

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Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with β-Glucan for High-Risk Neuroblastoma in Second or Later Remission

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Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

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Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

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Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

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Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study

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CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

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microRNA-26a suppresses recruitment of macrophages by down-regulating macrophage colony-stimulating factor expression through the PI3K/Akt pathway in hepatocellular carcinoma

Chai, Z., Zhu, X., Ao, J., Wang, W., Gao, D., Kong, J., Zhang, N., Zhang, Y., Ye, B., Ma, D.-N., et al. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0150-4 · Cited by 102 · see citing works

CCR9 in cancer: oncogenic role and therapeutic targeting

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Trabectedin for Soft Tissue Sarcoma: Current Status and Future Perspectives

Gordon, E. M., Sankhala, K. K., Chawla, N. S., & Chawla, S. P. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0344-3 · Cited by 97 · see citing works

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

Ambade, A., Satishchandran, A., Saha, B., Gyöngyösi, B., Lowe, P., Kodys, K., Catalano, D. E., & Szabó, G. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1221557 · Cited by 96 · see citing works

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

Finkernagel, F., Reinartz, S., Lieber, S., Adhikary, T., Wortmann, A., Hoffmann, N., Bieringer, T., Nist, A., Stiewe, T., Jansen, J. M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12180 · Cited by 94 · see citing works

CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients

Li, Y., Wang, F., Wang, L., Huang, L. J., Wang, J., Zhang, B., & Zhang, Y. (2015) · Oncotarget · doi:10.18632/oncotarget.3547 · Cited by 93 · see citing works

MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages

Yamada, K., Uchiyama, A., Uehara, A., Perera, B., Ogino, S., Yokoyama, Y., Takeuchi, Y., Udey, M. C., Ishikawa, O., & Motegi, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2812 · Cited by 87 · see citing works

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma

Li, Y., Zheng, Y., Li, T., Wang, Q., Qian, J., Lu, Y., Zhang, M., Bi, E., Yang, M., Reu, F. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4523 · Cited by 83 · see citing works

Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages

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Thymosin α1 and cancer: action on immune effector and tumor target cells

Garaci, E., Pica, F., Serafino, A., Balestrieri, E., Matteucci, C., Moroni, G., Sorrentino, R., Zonfrillo, M., Pierimarchi, P., & Vallebona, P. S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06697.x · Cited by 70 · see citing works

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis

Tomita, T., Sakurai, Y., Ishibashi, S., & Maru, Y. (2011) · Oncogene · doi:10.1038/onc.2011.53 · Cited by 69 · see citing works

Prognostic Implication of M2 Macrophages Are Determined by the Proportional Balance of Tumor Associated Macrophages and Tumor Infiltrating Lymphocytes in Microsatellite-Unstable Gastric Carcinoma

Kim, K.-J., Wen, X.-Y., Yang, H. K., Kim, W. H., & Kang, G. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144192 · Cited by 69 · see citing works

Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1

Wang, H., Shao, Q., Sun, J., Ma, C., Gao, W., Wang, Q., Zhao, L., & Qu, X. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1122157 · Cited by 69 · see citing works

Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer

Boström, M., Irjala, H., Mirtti, T., Taimen, P., Kauko, T., Ålgars, A., Jalkanen, S., & Boström, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133552 · Cited by 68 · see citing works

Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4

Zhao, P., Gao, D., Wang, Q., Song, B., Shao, Q., Sun, J., Ji, C., Li, X., Li, P., & Qu, X. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.108 · Cited by 63 · see citing works

Post-Sepsis State Induces Tumor-Associated Macrophage Accumulation through CXCR4/CXCL12 and Favors Tumor Progression in Mice

Mota, J. M., Leite, C. A., de Souza, L. E. B., Melo, P. H., Nascimento, D. C., Wagatsuma, V. M. D. D., Temporal, J., Figueiredo, F., Noushmehr, H., Alves-Filho, J. C., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0170 · Cited by 63 · see citing works

Monocyte/macrophage‐derived soluble CD 163: a novel biomarker in multiple myeloma

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Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer

Pulaski, H. L., Spahlinger, G., Silva, I. A., McLean, K., Kueck, A. S., Reynolds, R. K., Coukos, G., Conejo-Garcia, J. R., & Buckanovich, R. J. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-49 · Cited by 61 · see citing works

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype

Xiao, G., Wang, X., Sheng, J., Lu, S., Yu, X., & Wu, J. D. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0110-z · Cited by 57 · see citing works

CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion

Wang, F., Li, Y., Gao, Q., Huang, L. J., Wang, L., Wang, J., Wang, S., Zhang, B., & Zhang, Y. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1701-9 · Cited by 56 · see citing works

Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

Deng, Y., Liu, W., Lian, Z., Li, X., & Hou, X. (2016) · Oncotarget · doi:10.18632/oncotarget.9438 · Cited by 54 · see citing works

Long non-coding RNAs in the regulation of myeloid cells

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A Phase II Efficacy and Safety, Open-Label, Multicenter Study of Imprime PGG Injection in Combination With Cetuximab in Patients With Stage IV KRAS-Mutant Colorectal Cancer

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