The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Epigenetics in hepatocellular carcinoma
Abstract
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC. The epigenetic processes include chromatin remodelling, histone alterations, DNA methylation, and noncoding RNA (ncRNA) expression and are connected with the progression and metastasis of HCC. Due to their potential reversibility, these epigenetic alterations are widely targeted for the development of biomarkers. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies that can provide a meaningful improvement in overall survival and prediction of therapeutic outcomes. In this article, we have summarised the epigenetic modifications involved in HCC progression and highlighted the potential biomarkers for diagnosis and drug development.
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4 retracted
Zhang, X., Wang, S., Wang, H., Cao, J., Huang, X., Chen, Z., Xu, P., Sun, G., Xu, J., Lv, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0935-5 · Cited by 842
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RetractedRong, D., Lu, C., Zhang, B., Fu, K., Zhao, S., Tang, W., & Cao, H. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0958-6 · Cited by 240
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RetractedRegulation of microRNA biogenesis
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The Biogenesis, Functions, and Challenges of Circular RNAs
Li, X., Yang, L., & Chen, L.-L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,062
Non-coding RNA networks in cancer
Anastasiadou, E., Jacob, L. S., & Slack, F. J. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.99 · Cited by 1,884
Towards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872
Functions of Site-Specific Histone Acetylation and Deacetylation
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The role of non-coding RNAs in oncology
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Cited by
Wu, T., Liao, L., Wu, T., Chen, S., Yi, Q., & Xu, M. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2283328 · Cited by 20
Metadata
- Authors
- Nagaraju, G. P., Dariya, B., Kasa, P., Peela, S., & El-Rayes, B. F.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 86
- Issue
- Pt 3
- Pages
- 622-632
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W3186287941
- Cited by
- 339
- References
- 137
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nagaraju, G. P., Dariya, B., Kasa, P., Peela, S., & El-Rayes, B. F. (2022). Epigenetics in hepatocellular carcinoma. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.07.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
