The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
The oral microbiota and its role in carcinogenesis
Open accessAbstract
Despite decades of research, cancer continues to be a major global health concern. In recent years, the role played by microorganisms in the development and progression of cancer has come under increased scrutiny. The aim of the present review is to highlight the main associations between members of the human oral microbiota and various cancers. The PubMed database was searched for available literature to outline the current state of understanding regarding the role of the oral microbiota and a variety of human cancers. Oral squamous cell carcinoma (OSCC) is associated with carriage of a number of oral bacteria (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus sp.), certain viruses (e.g., human papilloma virus, human herpes virus 8, herpes simplex virus 1 and Epstein-Barr virus) and yeast (Candida albicans). Moreover, members of the oral microbiota are associated with cancers of the esophagus, stomach, pancreas, colon/rectum and lung. Furthermore, the present review outlines a number of the carcinogenic mechanisms underlying the presented microbial associations with cancer. Such information may one day help clinicians to diagnose neoplastic diseases at earlier stages and prescribe treatments that take into account the possible microbial nature of carcinogenesis.
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Cites
1 retracted
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Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
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Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
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Variation in cancer risk among tissues can be explained by the number of stem cell divisions
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Cited by
Is Candida albicans a contributor to cancer? A critical review based on the current evidence
Wang, X., Zhang, W., Wu, W., Wu, S., Young, A., & Yan, Z. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127370 · Cited by 44
Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer
Volovat, C. C., Cosovanu, M. A., Ostafe, M.-R., Augustin, I. G., Volovat, C., Georgescu, B., & Volovat, S. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167837 · Cited by 8
Metadata
- Authors
- Stasiewicz, M., & Karpiński, T. M.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 86
- Issue
- Pt 3
- Pages
- 633-642
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W3213943554
- Cited by
- 282
- References
- 126
- FWCI
- 33.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
