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Cited by 57Hair Growth and Disordersdental development and anomaliesSkin and Cellular Biology Research

To grow or not to grow: Hair morphogenesis and human genetic hair disorders

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Duverger, Olivier, Morasso, Maria I.·2014·Seminars in Cell & Developmental Biology
DOI 10.1016/j.semcdb.2013.12.006PMC PMC3988237
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Abstract

Mouse models have greatly helped in elucidating the molecular mechanisms involved in hair formation and regeneration. Recent publications have reviewed the genes involved in mouse hair development based on the phenotype of transgenic, knockout and mutant animal models. While much of this information has been instrumental in determining molecular aspects of human hair development and cycling, mice exhibit a specific pattern of hair morphogenesis and hair distribution throughout the body that cannot be directly correlated to human hair. In this mini-review, we discuss specific aspects of human hair follicle development and present an up-to-date summary of human genetic disorders associated with abnormalities in hair follicle morphogenesis, structure or regeneration.

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  • The in vitro hair follicle developmental timeline corresponds well to that of human fetal hair follicle development in vivo: the hair placode, germ, peg, and follicle differentiation stages occur, mostly, between 80 and 170 days (12-25 gestational weeks), where the full anagen stage hair follicles develop by day 126 (18 gestational weeks).

    “The in vitro hair follicle developmental timeline corresponds well to that of human fetal hair follicle development in vivo: the hair placode, germ, peg, and follicle differentiation stages occur, mostly, between 80 and 170 days (12–25 gestational weeks), where the full anagen stage hair follicles develop by day 126 (18 gestational weeks; Fig. 1)”

    From Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells (2022) · cites this paper as [37]

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Sorted by citations

Authors
Duverger, O., & Morasso, M. I.
Affiliations
National Institutes of Health (US)
Corresponding author
Duverger, Olivier
ORCID
Duverger, Olivier
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2014-01
Volume
25-26
Pages
22-33
ISSN
1084-9521 (ISSN-L)
DOI
10.1016/j.semcdb.2013.12.006
PMC
PMC3988237
OpenAlex
W2006376890
Cited by
57
References
6
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 2
FWCI
0.79
Type
journal article
Language
en
Open access
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041171)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords
hair morphogenesis, hair follicle development, hair follicle regeneration, mouse model, hair distribution, hair cycle, hair follicle structure
MeSH terms
Alopecia, Animals, Disease Models, Animal, Hair, Hair Diseases, Humans, Morphogenesis, Hair Follicle, Mice

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