Epidermal patterning and induction of different hair types during mouse embryonic development
Open accessAbstract
An intriguing question in developmental biology is how epidermal pattern formation processes are established and what are the molecular mechanisms involved in these events. The establishment of the pattern is concomitant with the formation of ectodermal appendages, which involves complex interactions between the epithelium and the underlying mesenchyme. Among ectodermal appendages, hair follicles are the “mini organs” that produce hair shafts. Several developmental and structural features are common to all hair follicles and to the hair shaft they produce. However, many different hair types are produced in a single organism. Also, different characteristics can be observed depending on the part of the body where the hair follicle is formed. Here, we review the mechanisms involved in the patterning of different hair types during mouse embryonic development as well as the influence of the body axes on hair patterning. Birth Defects Research (Part C) 87:263–272, 2009. © 2009 Wiley‐Liss, Inc.
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Hair placodes were observed in the interface of dermal and epidermal layers, as the result of epidermal thickening.
“The hair placodes were observed in the interface of dermal and epidermal layers, as the result of epidermal thickening [20].”
From The empowering influence of air-liquid interface culture on skin organoid hair follicle development (2025) · cites this paper as [20]
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- Authors
- Duverger, O., & Morasso, M. I.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Duverger, Olivier
- Venue
- Birth Defects Research Part C: Embryo Today: Reviews
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 87
- Issue
- 3
- Pages
- 263-272
- ISSN
- 1542-975X (ISSN-L)
- 1542-9768
- PMC
- PMC2995294
- OpenAlex
- W2079615431
- Cited by
- 102
- References
- 67
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 8
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Birth Defects Research Part C Embryo Today Reviews (publishedVersion, public-domain)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041171)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epidermal patterning, hair follicle induction, hair shaft, epithelial-mesenchymal interactions, mouse embryo development, body axis, hair follicle development
- MeSH terms
- Animals, Embryo, Mammalian, Epidermis, Hair, Gene Expression Regulation, Developmental, Body Patterning, Embryonic Development, Mice
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