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The regulation of spermatogenesis by androgens

Open access
Smith, Lee B., Walker, William H.·2014·Seminars in Cell & Developmental Biology

Abstract

Testosterone is essential for maintaining spermatogenesis and male fertility. However, the molecular mechanisms by which testosterone acts have not begun to be revealed until recently. With the advances obtained from the use of transgenic mice lacking or overexpressing the androgen receptor, the cell specific targets of testosterone action as well as the genes and signaling pathways that are regulated by testosterone are being identified. In this review, the critical steps of spermatogenesis that are regulated by testosterone are discussed as well as the intracellular signaling pathways by which testosterone acts. We also review the functional information that has been obtained from the knock out of the androgen receptor from specific cell types in the testis and the genes found to be regulated after altering testosterone levels or androgen receptor expression.

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Crossref · 10.1016/j.semcdb.2014.02.012

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Metadata

Authors
Smith, L. B., & Walker, W. H.
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2014-06
Volume
30
Pages
2-13
ISSN
1084-9521 (ISSN-L)
OpenAlex
W2004469122
Cited by
842
References
1
FWCI
38.31
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The regulation of spermatogenesis by androgens. https://app.cochat.ai/papers/10.1016/j.semcdb.2014.02.012
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Smith, L. B., & Walker, W. H. (2014). The regulation of spermatogenesis by androgens. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2014.02.012

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.