The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The regulation of spermatogenesis by androgens
Open accessAbstract
Testosterone is essential for maintaining spermatogenesis and male fertility. However, the molecular mechanisms by which testosterone acts have not begun to be revealed until recently. With the advances obtained from the use of transgenic mice lacking or overexpressing the androgen receptor, the cell specific targets of testosterone action as well as the genes and signaling pathways that are regulated by testosterone are being identified. In this review, the critical steps of spermatogenesis that are regulated by testosterone are discussed as well as the intracellular signaling pathways by which testosterone acts. We also review the functional information that has been obtained from the knock out of the androgen receptor from specific cell types in the testis and the genes found to be regulated after altering testosterone levels or androgen receptor expression.
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Citations
Cites
The simultaneous radioimmunoassay of seven steroids in human spermatic and peripheral venous blood
HAMMOND, G. L., RUOKONEN, A., KONTTURI, M., KOSKELA, E., & VIHKO, R. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-1-16 · Cited by 138
Cited by
Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone
Ramaswamy, S., & Weinbauer, G. F. (2014) · Spermatogenesis · doi:10.1080/21565562.2014.996025 · Cited by 411
Helo, S., Ellen, J., Mechlin, C., Feustel, P., Grossman, M., Ditkoff, E., & McCullough, A. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12944 · Cited by 102
Female chemical signalling underlying reproduction in mammals
Coombes, H. A., Stockley, P., & Hurst, J. L. (2018) · Journal of Chemical Ecology · doi:10.1007/s10886-018-0981-x · Cited by 98
Deng, Q., Zhang, Z., Wu, Y., Yu, W.-Y., Zhang, J., Jiang, Z.-M., Zhang, Y., Liang, H., & Gui, Y.-T. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480343 · Cited by 49
Zhang, X.-D., Sun, J., Zheng, X.-M., Zhang, J., Tan, L.-L., Fan, L.-L., Luo, Y.-X., Hu, Y.-F., Xu, S.-D., Zhou, H., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103312 · Cited by 47
Metadata
- Authors
- Smith, L. B., & Walker, W. H.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 30
- Pages
- 2-13
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2004469122
- Cited by
- 842
- References
- 1
- FWCI
- 38.31
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.