The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes
Open accessAbstract
Since their first description, extracellular vesicles (EVs) have been the topic of avid study in a variety of physiologic contexts and are now thought to play an important role in cancer. The state of knowledge on biogenesis, molecular content and horizontal communication of diverse types of cancer EVs has expanded considerably in recent years. As a consequence, a plethora of information about EV composition and molecular pathways involved in the regulation of important biological processes has emerged, along with the notion that cancer cells rely on these particles to invade tissues and propagate oncogenic signals at distance. In vivo studies, designed to achieve a deeper understanding of the extent to which EV biology can be applied to clinically relevant settings, are increasing. This review will summarize recent studies on EVs functionally implicated in cancer, with a focus on a novel EV population referred to as large oncosomes, which originate from highly migratory, amoeboid tumor cells. Here we provide an overview about the biogenesis and composition of exosomes, microvesicles and large oncosomes, along with their cancer-specific and more general functions. We also discuss current challenges and emerging technologies that might improve EV detection in various systems. Further studies on the functional role of EVs in specific steps of cancer formation and progression will expand our understanding of the diversity of paracrine signaling mechanisms in malignant growth.
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Cites
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Cited by
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Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
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Metadata
- Authors
- Minciacchi, V. R., Freeman, M. R., & Di Vizio, D.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 40
- Pages
- 41-51
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2038744035
- Cited by
- 963
- References
- 147
- FWCI
- 24.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Minciacchi, V. R., Freeman, M. R., & Di Vizio, D. (2015). Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2015.02.010
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