Shedding light on the cell biology of extracellular vesicles

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

On Respiratory Impairment in Cancer Cells

Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · see citing works

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works

The Mechanisms of Vesicle Budding and Fusion

Bonifacino, J. S., & Glick, B. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01079-1 · Cited by 1,863 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,773 · see citing works

Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works

The Nature and Significance of Platelet Products in Human Plasma

Wolf, P. (1967) · British Journal of Haematology · doi:10.1111/j.1365-2141.1967.tb08741.x · Cited by 1,725 · see citing works

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Börger, V., Buzás, E. I., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., Portillo, H. A. D., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,613 · see citing works

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Thakur, B. K., Zhang, H., Becker, A., Matei, I. R., Huang, Y., Costa‐Silva, B., Zheng, Y., Hoshino, A., Brazier, H., Xiang, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.44 · Cited by 1,592 · see citing works

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564 · see citing works

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works

ARF proteins: roles in membrane traffic and beyond

D’Souza‐Schorey, C., & Chavrier, P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1910 · Cited by 1,362 · see citing works

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

Bruno, S., Grange, C., Deregibus, M. C., Calogero, R., Saviozzi, S., Collino, F., Morando, L., Busca, A., Falda, M., Bussolati, B., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008070798 · Cited by 1,332 · see citing works

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284 · see citing works

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242 · see citing works

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A. B. H., Aguor, E. N. E., Timmers, L., van Rijen, H. V. M., Doevendans, P. A., Pasterkamp, G., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.01.002 · Cited by 1,108 · see citing works

Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

Trams, E. G., Lauter, C. J., Salem, N., & Heine, U. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90512-5 · Cited by 1,094 · see citing works

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075 · see citing works

Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

Conde, I. D., Shrimpton, C. N., Thiagarajan, P., & López, J. A. (2005) · Blood · doi:10.1182/blood-2004-03-1095 · Cited by 1,030 · see citing works

Active Wnt proteins are secreted on exosomes

Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works

Methodological Guidelines to Study Extracellular Vesicles

Coumans, F. A. W., Brisson, A. R., Buzás, E. I., Dignat‐George, F., Drees, E. E. E., Andaloussi, S. E., Emanueli, C., Gąsecka, A., Hendrix, A., Hill, A. F., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.309417 · Cited by 1,024 · see citing works

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

Gibbings, D., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 990 · see citing works

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Feng, D., Zhao, W.-L., Ye, Y.-Y., Bai, X., Liu, R.-Q., Chang, L.-F., Zhou, Q., & Sui, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01041.x · Cited by 983 · see citing works

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Säftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 955 · see citing works

Cells release subpopulations of exosomes with distinct molecular and biological properties

Willms, E., Johansson, H. J., Mäger, I., Lee, Y., Blomberg, K. E. M., Sadik, M., Alaarg, A., Smith, C. I. E., Lehtiö, J., Andaloussi, S. E., et al. (2016) · Scientific Reports · doi:10.1038/srep22519 · Cited by 953 · see citing works

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works

Exosomes: A Common Pathway for a Specialized Function

van Niel, G., Porto-Carreiro, I., Simoes, S., & Raposo, G. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj128 · Cited by 922 · see citing works

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Muralidharan-Chari, V., Clancy, J., Plou, C., Romao, M., Chavrier, P., Raposo, G., & D'Souza-Schorey, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.059 · Cited by 912 · see citing works

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

Minciacchi, V. R., Freeman, M., & Vizio, D. D. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.010 · Cited by 900 · see citing works

Exosomes are released by cultured cortical neurones

Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896 · see citing works

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 865 · see citing works

As we wait: coping with an imperfect nomenclature for extracellular vesicles

Gould, S. J., & Raposo, G. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20389 · Cited by 864 · see citing works

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

Hsu, C., Morohashi, Y., Yoshimura, S., Manrique‐Hoyos, N., Jung, S., Lauterbach, M. A., Bakhti, M., Grønborg, M., Möbius, W., Rhee, J., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911018 · Cited by 860 · see citing works

Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.

Record, M., Carayon, K., Poirot, M., & Silvente-Poirot, S. (2014) · Biochimica et Biophysica Acta · doi:10.1016/j.bbalip.2013.10.004 · Cited by 841 · see citing works

Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R., de Wit, E., Berenguer, J., Ellenbroek, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 815 · see citing works

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Besse, B., Charrier, M., Lapierre, V., Dansin, É., Lantz, O. J., Planchard, D., Chevalier, T. L., Livartoski, A., Barlési, F., Laplanche, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1071008 · Cited by 802 · see citing works

Circulating microparticles: pathophysiology and clinical implications

Piccin, A., Murphy, W. G., & Smith, O. P. (2006) · Blood Reviews · doi:10.1016/j.blre.2006.09.001 · Cited by 799 · see citing works

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

Deatherage, B. L., & Cookson, B. T. (2012) · Infection and Immunity · doi:10.1128/iai.06014-11 · Cited by 765 · see citing works

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

Hoen, E. N. M. N., Buermans, H. P. J., Waasdorp, M., Stoorvogel, W., Wauben, M. H. M., & Hoen, P. A. C. ’. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks658 · Cited by 741 · see citing works

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

Ma, L., Li, Y., Peng, J., Wu, D., Zhao, X., Cui, Y., Chen, L., Yan, X., Du, Y., & Yu, L. (2014) · Cell Research · doi:10.1038/cr.2014.135 · Cited by 737 · see citing works

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 731 · see citing works

Exosomes and other extracellular vesicles in host–pathogen interactions

Schorey, J. S., Cheng, Y., Singh, P., & Smith, V. L. (2014) · EMBO Reports · doi:10.15252/embr.201439363 · Cited by 729 · see citing works

Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

Tian, T., Zhu, Y.-L., Zhou, Y.-Y., Liang, G.-F., Wang, Y.-Y., Hu, F.-H., & Xiao, Z.-D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588046 · Cited by 726 · see citing works

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

Mateescu, B., Kowal, E. J. K., van Balkom, B. W. M., Bartel, S., Bhattacharyya, S. N., Buzás, E. I., Buck, A. H., de Candia, P., Chow, F. W., Das, S., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1286095 · Cited by 726 · see citing works

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

Nabhan, J. F., Hu, R., Oh, R. S., Cohen, S. N., & Lu, Q. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200448109 · Cited by 722 · see citing works

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Glued and late endosome positioning

Rocha, N., Kuijl, C. P., van der Kant, R., Janssen, L., Houben, D., Janssen, H., Zwart, W. T., & Neefjes, J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811005 · Cited by 705 · see citing works

Intestinal epithelial cells secrete exosome–like vesicles

van Niel, G., Raposo, G., Candalh, C., Boussac, M., Hershberg, R. M., Cerf–Bensussan, N., & Heyman, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.26263 · Cited by 698 · see citing works

Coats, Tethers, Rabs, and SNAREs Work Together to Mediate the Intracellular Destination of a Transport Vesicle

Cai, H., Reinisch, K. M., & Ferro‐Novick, S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.005 · Cited by 686 · see citing works

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2470 · Cited by 686 · see citing works

Lipid raft-associated protein sorting in exosomes

Gassart, A. D., Géminard, C., Février, B., Raposo, G., & Vidal, M. (2003) · Blood · doi:10.1182/blood-2003-03-0871 · Cited by 675 · see citing works

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

Sims, P. J., Faioni, E. M., Wiedmer, T., & Shattil, S. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81346-7 · Cited by 673 · see citing works

Interaction and uptake of exosomes by ovarian cancer cells

Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666 · see citing works

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

Shurtleff, M. J., Karfilis, K. V., Temoche-Diaz, M. M., Ri, S., & Schekman, R. W. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 648 · see citing works

Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia

Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596 · see citing works

Biology and biogenesis of shed microvesicles

Tricarico, C. J., Clancy, J. W., & D’Souza‐Schorey, C. (2016) · Small GTPases · doi:10.1080/21541248.2016.1215283 · Cited by 588 · see citing works

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., & Théry, C. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18397 · Cited by 581 · see citing works

Directional cell movement through tissues is controlled by exosome secretion

Sung, B., Ketova, T., Hoshino, D., Zijlstra, A., & Weaver, A. M. (2015) · Nature Communications · doi:10.1038/ncomms8164 · Cited by 563 · see citing works

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508014 · Cited by 562 · see citing works

Exosomes for targeted siRNA delivery across biological barriers

Andaloussi, S. E., Lakhal‐Littleton, S., Mäger, I., & Wood, M. J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.008 · Cited by 545 · see citing works

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

Fader, C. M., Sánchez, D. G., Mestre, M. B., & Colombo, M. I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.011 · Cited by 544 · see citing works

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

Pérez-Hernández, D., Gutiérrez‐Vázquez, C., Jorge, I., López‐Martín, S., Ursa, Á., Sánchez‐Madrid, F., Vázquez, J., & Yáñez‐Mó, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445304 · Cited by 534 · see citing works

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkersPreprint

D’Souza‐Schorey, C., & Clancy, J. W. (2012) · Genes & Development · doi:10.1101/gad.192351.112 · Cited by 528 · see citing works

Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis

Jimenez, J. J., Jy, W., Mauro, L. M., Soderland, C., Horstman, L. L., & Ahn, Y. S. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00064-1 · Cited by 515 · see citing works

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., & Caplan, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002049 · Cited by 514 · see citing works

Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner

Savina, A., Fader, C. M., Damiani, M. T., & Colombo, M. I. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00257.x · Cited by 512 · see citing works

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

Antonyak, M. A., Li, B., Boroughs, L. K., Johnson, J. L., Druso, J. E., Bryant, K. L., Holowka, D. A., & Cerione, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017667108 · Cited by 497 · see citing works

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G., & Bieberich, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.012 · Cited by 494 · see citing works

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410041111 · Cited by 493 · see citing works

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Villarroya‐Beltri, C., Baixauli, F., Mittelbrunn, M., Fernández‐Delgado, I., Torralba, D., Moreno-Gonzalo, O., Baldanta, S., Enrich, C., Guerra, S., & Sánchez‐Madrid, F. (2016) · Nature Communications · doi:10.1038/ncomms13588 · Cited by 489 · see citing works

Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro

Hristov, M., Erl, W., Linder, S., & Weber, P. C. (2004) · Blood · doi:10.1182/blood-2003-10-3614 · Cited by 485 · see citing works

ESCRT complexes and the biogenesis of multivesicular bodies

Hurley, J. H. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.12.002 · Cited by 482 · see citing works

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Fais, S., O’Driscoll, L., Borras, F. E., Buzas, E., Camussi, G., Cappello, F., Carvalho, J., Cordeiro da Silva, A., Del Portillo, H., El Andaloussi, S., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b08015 · Cited by 481 · see citing works

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

Teng, Y., Ren, Y., Hu, X., Mu, J., Samykutty, A. K., Zhuang, X., Deng, Z., Kumar, A., Zhang, L., Merchant, M. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14448 · Cited by 479 · see citing works

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live‐cell microscopy

Tian, T., Wang, Y., Wang, H., Zhu, Z., & Xiao, Z. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22733 · Cited by 457 · see citing works

Tetraspanins at a glance

Charrin, S., Jouannet, S., Boucheix, C., & Rubinstein, E. (2014) · Journal of Cell Science · doi:10.1242/jcs.154906 · Cited by 454 · see citing works

Extracellular vesicles shuffling intercellular messages: for good or for bad.

Cicero, A. L., Stahl, P., & Raposo, G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.013 · Cited by 453 · see citing works

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453 · see citing works

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C. H., & Geuze, H. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1259 · Cited by 451 · see citing works

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447 · see citing works

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S., Ji, H. L., & Simpson, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021303 · Cited by 446 · see citing works

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

Hoen, E. N. M. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W., & Wauben, M. H. M. (2008) · Blood · doi:10.1182/blood-2008-08-174094 · Cited by 436 · see citing works

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways

Buschow, S. I., Hoen, E. N. M. N., van Niel, G., Pols, M. S., ten Broeke, T., Lauwen, M. M., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., Wubbolts, R., et al. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00963.x · Cited by 430 · see citing works

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

McKenzie, A. J., Hoshino, D., Hong, N. H., Cha, D. J., Franklin, J. L., Coffey, R. J., Patton, J. G., & Weaver, A. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.085 · Cited by 423 · see citing works

Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding.

Harding, C. V., Heuser, J., & Stahl, P. D. (1984) · PubMed · Cited by 415 · see citing works

Accumulation of Major Histocompatibility Complex Class II Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation

Raposo, G., Tenza, D., Mecheri, S., Péronet, R., Bonnerot, C., & Desaymard, C. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2631 · Cited by 406 · see citing works

The Complex Ultrastructure of the Endolysosomal SystemPreprint

Klumperman, J., & Raposo, G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016857 · Cited by 391 · see citing works

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

Li, B., Antonyak, M. A., Zhang, J., & Cerione, R. A. (2012) · Oncogene · doi:10.1038/onc.2011.636 · Cited by 378 · see citing works

Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide.

Satta, N., Toti, F., Feugeas, O., Bohbot, A., Dachary-Prigent, J., Eschwège, V., Hedman, H., & Freyssinet, J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.7.3245 · Cited by 372 · see citing works

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337 · see citing works

Cortactin promotes exosome secretion by controlling branched actin dynamics

Sinha, S., Hoshino, D., Hong, N. H., Kirkbride, K. C., Grega‐Larson, N. E., Seiki, M., Tyska, M. J., & Weaver, A. M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201601025 · Cited by 330 · see citing works

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3451 · Cited by 326 · see citing works

ALIX and the multivesicular endosome: ALIX in Wonderland

Bissig, C., & Gruenberg, J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.10.009 · Cited by 323 · see citing works

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

Kajimoto, T., Okada, T., Miya, S., Zhang, L., & Nakamura, S. (2013) · Nature Communications · doi:10.1038/ncomms3712 · Cited by 318 · see citing works

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Wei, Y., Wang, D., Jin, F., Bian, Z., Li, L., Liang, H., Li, M., Shi, L., Pan, C., Zhu, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14041 · Cited by 316 · see citing works

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

Roucourt, B., Meeussen, S., Bao, J., Zimmermann, P., & David, G. (2015) · Cell Research · doi:10.1038/cr.2015.29 · Cited by 310 · see citing works

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Zimmerman, B., Kelly, B., McMillan, B. J., Seegar, T. C. M., Dror, R. O., Kruse, A. C., & Blacklow, S. C. (2016) · Cell · doi:10.1016/j.cell.2016.09.056 · Cited by 307 · see citing works

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

Purushothaman, A., Bandari, S., Liu, J., Mobley, J. A., Brown, E. E., & Sanderson, R. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686295 · Cited by 304 · see citing works

Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O

Möbius, W., Ohno‐Iwashita, Y., van Donselaar, E. G., Oorschot, V. M. J., Shimada, Y., Fujimoto, T., Heijnen, H. F. G., Geuze, H. J., & Slot, J. W. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000105 · Cited by 302 · see citing works

Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses

Segura, É., Amigorena, S., & Théry, C. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.05.003 · Cited by 301 · see citing works

Dendritic Cell–Derived Exosomes as Immunotherapies in the Fight against Cancer

Pitt, J. M., Charrier, M., Viaud, S., André, F., Besse, B., Chaput, N., & Zitvogel, L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400703 · Cited by 296 · see citing works

The role of integrin binding sites in fibronectin matrix assembly in vivo

Leiß, M., Beckmann, K., Girós, A., Costell, M., & Fässler, R. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.06.001 · Cited by 296 · see citing works

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

Barrès, C., Blanc, L., Bette‐Bobillo, P., André, S., Mamoun, R. Z., Gabius, H., & Vidal, M. (2009) · Blood · doi:10.1182/blood-2009-07-231449 · Cited by 295 · see citing works

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

Liégeois, S., Benedetto, A., Garnier, J., Schwab, Y., & Labouesse, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511072 · Cited by 294 · see citing works

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

Exner, T., Ma, D. D. F., Joseph, J. E., & CONNOR, D. E. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-09-0644 · Cited by 291 · see citing works

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

Bolukbasi, M. F., Mizrak, A., Ozdener, G. B., Madlener, S., Ströbel, T., Erkan, E. P., Fan, J., Breakefield, X. O., & Saydam, O. (2012) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2011.2 · Cited by 290 · see citing works

A Lumenal Domain-Dependent Pathway for Sorting to Intralumenal Vesicles of Multivesicular Endosomes Involved in Organelle Morphogenesis

Theos, A. C., Truschel, S. T., Tenza, D., Hurbain, I., Harper, D. C., Berson, J. F., Thomas, P. C., Raposo, G., & Marks, M. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.012 · Cited by 289 · see citing works

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A., Radtke, S., Peters, V. B. M., Janssen, L. E. W., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0197 · Cited by 278 · see citing works

T84-Intestinal Epithelial Exosomes Bear MHC Class II/Peptide Complexes Potentiating Antigen Presentation by Dendritic Cells

Mallegol, J., van Niel, G., Lebreton, C., Lepelletier, Y., Candalh, C., Dugave, C., Heath, J. K., Raposo, G., Cerf–Bensussan, N., & Heyman, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.043 · Cited by 271 · see citing works

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

Nakase, I., Kobayashi, N. B., Takatani‐Nakase, T., & Yoshida, T. (2015) · Scientific Reports · doi:10.1038/srep10300 · Cited by 271 · see citing works

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

Tamai, K., Tanaka, N., Nakano, T., Kakazu, E., Kondo, Y., Inoue, J., Shiina, M., Fukushima, K., Hoshino, T., Sano, K., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.083 · Cited by 269 · see citing works

PIKfyve inhibition increases exosome release and induces secretory autophagy

Hessvik, N. P., Øverbye, A., Brech, A., Torgersen, M. L., Jakobsen, I. S., Sandvig, K., & Llorente, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2309-8 · Cited by 269 · see citing works

Lysosome-related organelles: unusual compartments become mainstream

Marks, M. S., Heijnen, H. F. G., & Raposo, G. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.04.008 · Cited by 266 · see citing works

The enterocyte microvillus is a vesicle-generating organelle

McConnell, R. E., Higginbotham, J. N., Shifrin, D. A., Tabb, D. L., Coffey, R. J., & Tyska, M. J. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902147 · Cited by 260 · see citing works

Exosomes released by keratinocytes modulate melanocyte pigmentation

Cicero, A. L., Delevoye, C., Gilles-Marsens, F., Loew, D., Dingli, F., Guéré, C., André, N., Vié, K., van Niel, G., & Raposo, G. (2015) · Nature Communications · doi:10.1038/ncomms8506 · Cited by 255 · see citing works

Impact of lysosome status on extracellular vesicle content and release

Eitan, E., Suire, C. N., Zhang, S., & Mattson, M. P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.001 · Cited by 255 · see citing works

Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles

Stein, J. M., & Luzio, J. P. (1991) · Biochemical Journal · doi:10.1042/bj2740381 · Cited by 242 · see citing works

Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes

Takov, K., Yellon, D. M., & Davidson, S. M. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1388731 · Cited by 242 · see citing works

bicoid RNA localization requires specific binding of an endosomal sorting complex

Irion, U., & Johnston, D. S. (2007) · Nature · doi:10.1038/nature05503 · Cited by 236 · see citing works

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

van Dongen, H. V., Masoumi, N., Witwer, K., & Pegtel, D. (2016) · Microbiology and Molecular Reviews · doi:10.1128/mmbr.00063-15 · Cited by 236 · see citing works

RAL-1 controls multivesicular body biogenesis and exosome secretion

Hyenne, V., Apaydin, A., Rodriguez, D., Spiegelhalter, C., Hoff-Yoessle, S., Diem, M., Tak, S., Lefèbvre, O., Schwab, Y., Goetz, J. G., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201504136 · Cited by 230 · see citing works

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

Desrochers, L. M., Bordeleau, F., Reinhart‐King, C. A., Cerione, R. A., & Antonyak, M. A. (2016) · Nature Communications · doi:10.1038/ncomms11958 · Cited by 229 · see citing works

Hrs‐ and CD63 ‐Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

Edgar, J. R., Eden, E. R., & Futter, C. E. (2013) · Traffic · doi:10.1111/tra.12139 · Cited by 224 · see citing works

Effects of ceramide and other simple sphingolipids on membrane lateral structure

Goñi, F. M., & Alonso, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.002 · Cited by 224 · see citing works

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

Puri, N., & Roche, P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707854105 · Cited by 223 · see citing works

Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.

Zimmermann, P., Zhang, Z., Degeest, G., Mortier, E., Leenaerts, I., Coomans, C., Schulz, J., N’Kuli, F., Courtoy, P. J., & David, G. (2005) · PubMed · doi:10.1016/j.devcel.2005.07.011 · Cited by 218 · see citing works

Degradation of AP2 During Reticulocyte Maturation Enhances Binding of Hsc70 and Alix to a Common Site on TfR for Sorting into Exosomes

Géminard, C., Gassart, A. D., Blanc, L., & Vidal, M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.0167.x · Cited by 217 · see citing works

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

Vargas, A., Zhou, S., Éthier‐Chiasson, M., Flipo, D., Lafond, J., Gilbert, C., & Barbeau, B. (2014) · The FASEB Journal · doi:10.1096/fj.13-239053 · Cited by 209 · see citing works

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

Coleman, B. M., & Hill, A. F. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.02.007 · Cited by 208 · see citing works

Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination

van Niel, G., Wubbolts, R., ten Broeke, T., Buschow, S. I., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., van Balkom, B. W. M., & Stoorvogel, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.11.001 · Cited by 195 · see citing works

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

Carayon, K., Chaoui, K., Ronzier, E., Lazar, I., Bertrand‐Michel, J., Roques, V., Balor, S., Tercé, F., Lopez, A., Salomé, L., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257444 · Cited by 187 · see citing works

The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos

Wehman, A. M., Poggioli, C., Schweinsberg, P. J., Grant, B. D., & Nance, J. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.040 · Cited by 185 · see citing works

Exosomes contain ubiquitinated proteins

Buschow, S. I., Liefhebber, J. M. P., Wubbolts, R., & Stoorvogel, W. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.08.005 · Cited by 185 · see citing works

Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation

Vidal, M., Mangeat, P. H., & Hoekstra, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.16.1867 · Cited by 184 · see citing works

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons

Laulagnier, K., Javalet, C., Hemming, F. J., Chivet, M., Lachenal, G. M., Blot, B., Chatellard, C., & Sadoul, R. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2664-0 · Cited by 169 · see citing works

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

Sedgwick, A., Clancy, J. W., Balmert, M. O., & D’Souza‐Schorey, C. (2015) · Scientific Reports · doi:10.1038/srep14748 · Cited by 163 · see citing works

Tetherin is an exosomal tether

Edgar, J. R., Manna, P. T., Nishimura, S., Banting, G., & Robinson, M. S. (2016) · eLife · doi:10.7554/elife.17180 · Cited by 161 · see citing works

The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

Ranghino, A., Bruno, S., Bussolati, B., Moggio, A., Dimuccio, V., Tapparo, M., Biancone, L., Gontero, P., Frea, B., & Camussi, G. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0478-5 · Cited by 157 · see citing works

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

Song, P., Trajković, K., Tsunemi, T., & Krainc, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2569-15.2016 · Cited by 154 · see citing works

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

Wasmuth, E. V., Januszyk, K., & Lima, C. D. (2014) · Nature · doi:10.1038/nature13406 · Cited by 151 · see citing works

Unconventional protein secretion in plants: a critical assessment

Robinson, D. G., Ding, Y., & Jiang, L. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0887-1 · Cited by 146 · see citing works

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

van Niel, G., Bergam, P., Cicco, A. D., Hurbain, I., Cicero, A. L., Dingli, F., Palmulli, R., Fort, C., Potier, M., Schurgers, L. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.057 · Cited by 143 · see citing works

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

Schlienger, S., Campbell, S. L., & Claing, A. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-06-0335 · Cited by 141 · see citing works

Accelerated growth of B16 BL 6 tumor in mice through efficient uptake of their own exosomes by B16 BL 6 cells

Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., Saji, H., & Takakura, Y. (2017) · Cancer Science · doi:10.1111/cas.13310 · Cited by 133 · see citing works

Tetherin is an exosomal tether.

Edgar, J. R., Manna, P. T., Nishimura, S., Banting, G. S., & Robinson, M. S. (2016) · Apollo (University of Cambridge) · doi:10.17863/cam.27767 · Cited by 126 · see citing works

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Gauthier, S. A., Pérez‐González, R., Sharma, A., Huang, F.-K., Alldred, M. J., Pawlik, M., Kaur, G., Ginsberg, S. D., Neubert, T. A., & Levy, E. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0466-0 · Cited by 125 · see citing works

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

Beauvillain, C., Juste, M., Dion, S., Pierre, J., & Dimier‐Poisson, I. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.022 · Cited by 117 · see citing works

Shedding of Membrane Vesicles Mediates Fibroblast Growth Factor-2 Release from Cells

Taverna, S., Ghersi, G., Ginestra, A., Rigogliuso, S., Pecorella, S., Alaimo, G., Saladino, F., Dolo, V., Dell’Era, P., Pavan, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304192200 · Cited by 110 · see citing works

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Guix, F. X., Sannerud, R., Berditchevski, F., Arranz, A. M., Horré, K., Snellinx, A., Thathiah, A., Saido, T. C., Saito, T., Rajesh, S., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0165-0 · Cited by 98 · see citing works

Microvesicle‐Shuttled miR‐130b Reduces Fat Deposition in Recipient Primary Cultured Porcine Adipocytes by Inhibiting PPAR‐γ Expression

Pan, S., Yang, X., Jia, Y., Li, R., & Zhao, R. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24486 · Cited by 97 · see citing works

The immune functions of phosphatidylserine in membranes of dying cells and microvesicles

Frey, B., & Gaipl, U. S. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0228-6 · Cited by 97 · see citing works

Biogenesis of the Posterior Pole Is Mediated by the Exosome/Microvesicle Protein-sorting Pathway

Shen, B., Fang, Y., Wu, N., & Gould, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274803 · Cited by 95 · see citing works

Expression of the Longin domain of TI‐VAMP impairs lysosomal secretion and epithelial cell migration

Proux‐Gillardeaux, V., Raposo, G., Irinopoulou, T., & Galli, T. (2007) · Biology of the Cell · doi:10.1042/bc20060097 · Cited by 95 · see citing works

The cis-acting signals that target proteins to exosomes and microvesicles

Yang, J.-M., & Gould, S. J. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120275 · Cited by 88 · see citing works

Rho GTPases and their roles in cancer metabolism

Wilson, K. F., Erickson, J. W., Antonyak, M. A., & Cerione, R. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.10.011 · Cited by 87 · see citing works

Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4

Thomas, L. M., & Salter, R. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001231 · Cited by 78 · see citing works

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

Gerber, P. P., Cabrini, M., Jancic, C. C., Paoletti, L., Banchio, C., von Bilderling, C., Sigaut, L., Pietrasanta, L. I., Duette, G., Freed, E. O., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409082 · Cited by 78 · see citing works

The emerging role of exosomes in Wnt secretion and transport.

Zhang, L., & Wrana, J. (2014) · Current Opinion in Genetics and Development · doi:10.1016/j.gde.2014.03.006 · Cited by 77 · see citing works

PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy

Dias, M. V. S., Teixeira, B. L., Rodrigues, B. R., Sinigaglia‐Coimbra, R., Porto-Carreiro, I., Roffé, M., Hajj, G. N. M., & Martins, V. R. (2016) · Autophagy · doi:10.1080/15548627.2016.1226735 · Cited by 74 · see citing works

Organizing polarized delivery of exosomes at synapses

Mittelbrunn, M., Vicente-Manzanares, M., & Sánchez-Madrid, F. (2015) · Traffic : the International Journal of Intracellular Transport · doi:10.1111/tra.12258 · Cited by 73 · see citing works

Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor

Odintsova, E., van Niel, G., Conjeaud, H., Raposo, G., Iwamoto, R., Mekada, E., & Berditchevski, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439380 · Cited by 66 · see citing works

A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers.

Prada, I., Amin, L., Furlan, R., Legname, G., Verderio, C., & Cojoc, D. (2016) · BioTechniques · doi:10.2144/000114371 · Cited by 63 · see citing works

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

Torrano, V., Royo, F., Peinado, H., Loizaga‐Iriarte, A., Unda, M., Falcón‐Pérez, J. M., & Carracedo, A. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.06.003 · Cited by 62 · see citing works

Autophagy and the endo/exosomal pathways in health and disease

Papandreou, M., & Tavernarakis, N. (2016) · Biotechnology Journal · doi:10.1002/biot.201600175 · Cited by 62 · see citing works

Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner

Luhtala, N., Aslanian, A., Yates, J. R., & Hunter, T. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.747618 · Cited by 53 · see citing works

Use of the Q-Switched 755-nm Alexandrite Laser to Treat Recalcitrant Pigment after Depigmentation Therapy for Vitiligo

Rao, J., & FITZPATRICK, R. E. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30313.x · Cited by 51 · see citing works

Exosomes go with the Wnt

Koles, K., & Budnik, V. (2012) · Cellular Logistics · doi:10.4161/cl.21981 · Cited by 44 · see citing works

Noninvasive In Vivo Monitoring of Extracellular Vesicles

Lai, C., Tannous, B., & Breakefield, X. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-718-1_19 · Cited by 44 · see citing works

Nanoscale Characterization of Carrier Dynamic and Surface Passivation in InGaN/GaN Multiple Quantum Wells on GaN Nanorods

Chen, W., Wen, X., Latzel, M., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11675 · Cited by 39 · see citing works

Going live with tumor exosomes and microvesicles

Hyenne, V., Lefèbvre, O., & Goetz, J. G. (2017) · Cell Adhesion & Migration · doi:10.1080/19336918.2016.1276694 · Cited by 37 · see citing works

Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F. J., & Sadoul, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24722

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Reassessment of exosome composition

Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975 · see citing works

RNA delivery by extracellular vesicles in mammalian cells and its applications

O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811 · see citing works

Sickle cell disease

Kato, G. J., Piel, F. B., Reid, C. D., Gaston, M. H., Ohene-Frempong, K., Krishnamurti, L., Smith, W. R., Panepinto, J. A., Weatherall, D. J., Costa, F. F., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.10 · Cited by 1,501 · see citing works

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Poggio, M., Hu, T., Pai, C.-C., Chu, B., Belair, C. D., Chang, A., Montabana, E., Lang, U. E., Fu, Q., Fong, L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.016 · Cited by 1,376 · see citing works

Challenges and directions in studying cell–cell communication by extracellular vesicles

van Niel, G., Carter, D. R. F., Clayton, A., Lambert, D. W., Raposo, G., & Vader, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00460-3 · Cited by 1,229 · see citing works

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980 · see citing works

The many functions of ESCRTs

Vietri, M., Radulovic, M., & Stenmark, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0177-4 · Cited by 962 · see citing works

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Mathieu, M., Névo, N., Jouve, M., Valenzuela, J. I., Maurin, M., Verweij, F. J., Palmulli, R., Lankar, D., Dingli, F., Loew, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24384-2 · Cited by 910 · see citing works

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

Skotland, T., Hessvik, N. P., Sandvig, K., & Llorente, A. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r084343 · Cited by 730 · see citing works

Therapeutically harnessing extracellular vesicles

Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737 · see citing works

Extracellular Vesicles and Nanoparticles: Emerging Complexities

Jeppesen, D. K., Zhang, Q., Franklin, J. L., & Coffey, R. J. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.002 · Cited by 705 · see citing works

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

Banks, W. A., Sharma, P., Bullock, K. M., Hansen, K. M., Ludwig, N., & Whiteside, T. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124407 · Cited by 561 · see citing works

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Joshi, A. U., Minhas, P. S., Liddelow, S. A., Haileselassie, B., Andreasson, K. I., Dorn, G. W., & Mochly-Rosen, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0486-0 · Cited by 571 · see citing works

Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471 · see citing works

Exosome engineering: Current progress in cargo loading and targeted delivery

Fu, S., Wang, Y., Xia, X., & Zheng, J. C. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100261 · Cited by 444 · see citing works

Engineered Extracellular Vesicles for Cancer Therapy

Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428 · see citing works

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

Maugeri, M., Nawaz, M., Papadimitriou, A., Angerfors, A., Camponeschi, A., Na, M., Hölttä, M., Skantze, P., Johansson, S., Sundqvist, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12275-6 · Cited by 428 · see citing works

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422 · see citing works

The cell biology of the retinal pigment epithelium

Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

Todkar, K., Chikhi, L., Desjardins, V., El-Mortada, F., Pépin, G., & Germain, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21984-w · Cited by 382 · see citing works

Extracellular Vesicle–Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

Yang, L., Han, B., Zhang, Z., Wang, S., Bai, Y., Zhang, Y., Tang, Y., Du, L., Xu, L., Wu, F., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.045765 · Cited by 376 · see citing works

Regulation of exosome production and cargo sorting

Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385 · see citing works

Extracellular vesicles: A bright star of nanomedicine

Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368 · see citing works

Extracellular vesicles: lipids as key components of their biogenesis and functions

Record, M., Silvente-Poirot, S., Poirot, M., & Wakelam, M. O. (2018) · Journal of Lipid Research · doi:10.1194/jlr.e086173 · Cited by 328 · see citing works

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2019) · Nanoscale · doi:10.1039/c9nr01255a · Cited by 324 · see citing works

Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy

Chen, H.-X., Liang, F.-C., Gu, P., Xu, B.-L., Xu, H.-J., Wang, W.-T., Hou, J.-Y., Xie, D.-X., Chai, X.-Q., & An, S.-J. (2020) · Cell Death &amp; Disease · doi:10.1038/s41419-020-2473-5 · Cited by 319 · see citing works

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314601 · Cited by 306 · see citing works

The function and clinical application of extracellular vesicles in innate immune regulation

Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F. (2020) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-020-0391-1 · Cited by 294 · see citing works

Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272 · see citing works

Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

Cao, J., Wang, B., Tang, T., Lv, L., Ding, Z., Li, Z., Hu, R., Wei, Q., Shen, A., Fu, Y., et al. (2020) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-020-01719-2 · Cited by 264 · see citing works

Neural stem cells traffic functional mitochondria via extracellular vesicles

Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology · doi:10.1371/journal.pbio.3001166 · Cited by 263 · see citing works

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262 · see citing works

Approaches to surface engineering of extracellular vesicles

Richter, M., Vader, P., & Fuhrmann, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.020 · Cited by 258 · see citing works

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

You, Y., Tian, Y., Yang, Z., Shi, J., Kwak, K. J., Tong, Y., Estania, A. P., Cao, J., Hsu, W.-H., Liu, Y., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00989-w · Cited by 258 · see citing works

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

Clement, E., Lazar, I., Attané, C., Carrié, L., Dauvillier, S., Ducoux‐Petit, M., Esteve, D., Menneteau, T., Moutahir, M., Le Gonidec, S., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019102525 · Cited by 240 · see citing works

Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects

Zha, Y., Li, Y., Lin, T., Chen, J., Zhang, S., & Wang, J. (2021) · Theranostics · doi:10.7150/thno.50741 · Cited by 232 · see citing works

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., George, A., Belcher, E., Zhu, D., Mei, X., et al. (2022) · Matter · doi:10.1016/j.matt.2022.06.012 · Cited by 218 · see citing works

Microglia in multiple sclerosis: Friend or foe

Guerrero, B. L., & Sicotte, N. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00374 · Cited by 215 · see citing works

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage

Fafián-Labora, J. A., Rodríguez-Navarro, J. A., & O’Loghlen, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.004 · Cited by 203 · see citing works

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Liu, Q., Li, D., Pan, X., & Liang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02081-0 · Cited by 201 · see citing works

Interactions between Muscle and Bone—Where Physics Meets Biology

Herrmann, M., Engelke, K., Ebert, R., Müller-Deubert, S., Rudert, M., Ziouti, F., Jundt, F., Felsenberg, D., & Jakob, F. (2020) · Biomolecules · doi:10.3390/biom10030432 · Cited by 197 · see citing works

Exosome for mRNA delivery: Strategies and therapeutic applications

Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144 · see citing works

Liquid biopsy in the clinical management of hepatocellular carcinoma

von Felden, J., Garcia-Lezana, T., Schulze, K., Losic, B., & Villanueva, A. (2020) · Gut · doi:10.1136/gutjnl-2019-320282 · Cited by 141 · see citing works

Forms of extracellular mitochondria and their impact in health

Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138 · see citing works

Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis

Casella, G., Colombo, F., Finardi, A., Descamps, H., Ill-Raga, G., Spinelli, A., Podini, P., Bastoni, M., Martino, G., Muzio, L., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.024 · Cited by 134 · see citing works

Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research

Ramirez-Garrastacho, M., Bajo-Santos, C., Line, A., Martens-Uzunova, E. S., de la Fuente, J. M., Moros, M., Soekmadji, C., Tasken, K. A., & Llorente, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-021-01610-8 · Cited by 130 · see citing works

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

Yang, B., Zhang, F., Cheng, F., Ying, L., Wang, C., Shi, K., Wang, J., Xia, K., Gong, Z., Huang, X., et al. (2020) · Cell Death &amp; Disease · doi:10.1038/s41419-020-2620-z · Cited by 128 · see citing works

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works

Determinants and functions of CAFs secretome during cancer progression and therapy

Linares, J., Marín-Jiménez, J. A., Badia-Ramentol, J., & Calon, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.621070 · Cited by 110 · see citing works

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

Chen, Y., Tian, Z., He, L., Liu, C., Wang, N., Rong, L., & Liu, B. (2021) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-021-02282-0 · Cited by 106 · see citing works

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis

Blaser, M. C., Buffolo, F., Halu, A., Turner, M. E., Schlotter, F., Higashi, H., Pantano, L., Clift, C. L., Saddic, L. A., Atkins, S. K., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.063402 · Cited by 114 · see citing works

Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease

Gabrielli, M., Prada, I., Joshi, P., Falcicchia, C., D’Arrigo, G., Rutigliano, G., Battocchio, E., Zenatelli, R., Tozzi, F., Radeghieri, A., et al. (2022) · Brain · doi:10.1093/brain/awac083 · Cited by 106 · see citing works

Exosomal PD‐L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies

Zhou, K., Guo, S., Li, F., Sun, Q., & Liang, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.569219 · Cited by 99 · see citing works

Therapeutic reversal of Huntington’s disease by <i>in vivo</i> self-assembled siRNAs

Zhang, L., Wu, T., Shan, Y., Li, G., Ni, X., Chen, X., Hu, X., Lin, L., Li, Y., Guan, Y., et al. (2021) · Brain · doi:10.1093/brain/awab354 · Cited by 97 · see citing works

Transfer of MicroRNA via Macrophage-Derived Extracellular Vesicles Promotes Proneural-to-Mesenchymal Transition in Glioma Stem Cells

Zhang, Z., Xu, J., Chen, Z., Wang, H., Xue, H., Yang, C., Guo, Q., Qi, Y., Guo, X., Qian, M., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0759 · Cited by 93 · see citing works

Melanin Transfer and Fate within Keratinocytes in Human Skin Pigmentation

Benito-Martínez, S., Salavessa, L., Raposo, G., Marks, M. S., & Delevoye, C. (2021) · Integrative and Comparative Biology · doi:10.1093/icb/icab094 · Cited by 78 · see citing works

Different sourced extracellular vesicles and their potential applications in clinical treatments

Bahmani, L., & Ullah, M. (2022) · Cells · doi:10.3390/cells11131989 · Cited by 83 · see citing works

Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles

Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79 · see citing works

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining

Liu, Y., Zhou, R., Guo, Y., Hu, B., Xie, L., An, Y., Wen, J., Liu, Z., Zhou, M., Kuang, W., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2024.12.005 · Cited by 78 · see citing works

The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia.

Gruzdev, S. K., Yakovlev, A. A., Druzhkova, T. A., Guekht, A. B., & Gulyaeva, N. V. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00684-6 · Cited by 75 · see citing works

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Pistono, C., Bister, N., Stanová, I., & Malm, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.623771 · Cited by 75 · see citing works

A size-exclusion-based approach for purifying extracellular vesicles from human plasma

Vanderboom, P. M., Dasari, S., Ruegsegger, G. N., Pataky, M. W., Lucien, F., Heppelmann, C. J., Lanza, I. R., & Nair, K. S. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100055 · Cited by 75 · see citing works

Extracellular vesicle PD‐L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies

Liu, J., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Zhang, S., He, G., Zheng, H., Fan, Q., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-021-00816-w · Cited by 75 · see citing works

Applications of Plant-Derived Extracellular Vesicles in Medicine

Zhu, Y., Zhao, J., Ding, H., Qiu, M., Xue, L., Ge, D., Wen, G., Ren, H., Li, P., & Wang, J. (2024) · MedComm · doi:10.1002/mco2.741 · Cited by 75 · see citing works

Engineered extracellular vesicles as brain therapeutics

Lino, M. M., Simões, S., Tomatis, F., Albino, I., Barrera, A., Vivien, D., Sobrino, T., & Ferreira, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.037 · Cited by 68 · see citing works

Extracellular Vesicles Derived from Senescent Fibroblasts Attenuate the Dermal Effect on Keratinocyte Differentiation

Choi, E.-J., Kil, I. S., & Cho, E.-G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031022 · Cited by 66 · see citing works

Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites

Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication

Filannino, F. M., Panaro, M. A., Benameur, T., Pizzolorusso, I., & Porro, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031629 · Cited by 60 · see citing works

Mesenchymal stem cell-derived exosomes suppress proliferation of T cells by inducing cell cycle arrest through p27kip1/Cdk2 signaling

Lee, S., Kim, S., Chung, H., Moon, J. H., Kang, S. J., & Park, C.-G. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.06.006 · Cited by 57 · see citing works

Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., Falzone, G. G., Giachino, C., Marchetti, B., & Iraci, N. (2021) · Aging and disease · doi:10.14336/ad.2021.0527 · Cited by 55 · see citing works

Selective Encapsulation of Therapeutic mRNA in Engineered Extracellular Vesicles by DNA Aptamer

Zhang, S., Dong, Y., Wang, Y., Sun, W., Wei, M., Yuan, L., & Yang, G. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01817 · Cited by 50 · see citing works

Huntingtin Co-Isolates with Small Extracellular Vesicles from Blood Plasma of TgHD and KI-HD Pig Models of Huntington’s Disease and Human Blood Plasma

Ananbeh, H., Novak, J., Juhas, S., Juhasova, J., Klempir, J., Doleckova, K., Rysankova, I., Turnovcova, K., Hanus, J., Hansikova, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105598 · Cited by 46 · see citing works

MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease

Li, W., & Zheng, Y. (2023) · Cells · doi:10.3390/cells12101378 · Cited by 43 · see citing works

Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia

Liu, Y., Wang, M., Liang, Y., Wang, C., Naruse, K., & Takahashi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041729 · Cited by 42 · see citing works

Unveiling the Complex Role of Exosomes in Alzheimer’s Disease

Sun, M., & Chen, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s466821 · Cited by 39 · see citing works

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

Graykowski, D. R., Wang, Y.-Z., Upadhyay, A., & Savas, J. N. (2020) · iScience · doi:10.1016/j.isci.2020.101456 · Cited by 39 · see citing works

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function

Quijano, L. M., Naranjo, J. D., El-Mossier, S. O., Turner, N. J., Pineda Molina, C., Bartolacci, J., Zhang, L., White, L., Li, H., & Badylak, S. F. (2020) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2020.0243 · Cited by 38 · see citing works

The Roles of Cardiac Fibroblasts and Endothelial Cells in Myocarditis

Xuan, Y., Chen, C., Wen, Z., & Wang, D. W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882027 · Cited by 35 · see citing works

Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles

Liu, X., Shen, L., Wan, M., Xie, H., & Wang, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02428-1 · Cited by 33 · see citing works

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Li, T., Tan, X., Li, S., Al-Nusaif, M., & Le, W. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.765395 · Cited by 33 · see citing works

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration

Li, S., Du, J., Huang, Y., Gao, S., Zhao, Z., Chang, Z., Zhang, X., & He, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355503 · Cited by 32 · see citing works

Differential RNA packaging into small extracellular vesicles by neurons and astrocytes

Luo, X., Jean-Toussaint, R., Sacan, A., & Ajit, S. K. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00757-4 · Cited by 32 · see citing works

Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration

Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32 · see citing works

Nanotechnology-Inspired Extracellular Vesicles Theranostics for Diagnosis and Therapy of Central Nervous System Diseases

Tian, T., Qiao, S., & Tannous, B. A. (2023) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.2c07981 · Cited by 27 · see citing works

Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy

Tang, Y., Liu, X., Sun, M., Xiong, S., Xiao, N., Li, J., He, X., & Xie, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071902 · Cited by 24 · see citing works

Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders: a cross-sectional study

Wallensten, J., Mobarrez, F., Åsberg, M., Borg, K., Beser, A., Wilczek, A., & Nager, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-96313-8 · Cited by 19 · see citing works

Melatonin Engineered Adipose-Derived Biomimetic Nanovesicles Regulate Mitochondrial Functions and Promote Myocardial Repair in Myocardial Infarction

Zhang, Y., Yang, N., Huang, X., Zhu, Y., Gao, S., Liu, Z., Cao, F., & Wang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.789203 · Cited by 18 · see citing works

Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases

Ferrantelli, F., Chiozzini, C., Leone, P., Manfredi, F., & Federico, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060529 · Cited by 17 · see citing works

Therapeutic Strategies and Enhanced Production of Stem Cell-Derived Exosomes for Tissue Regeneration

Kim, H., Kim, D., Kim, W., Lee, S., Gwon, Y., Park, S., & Kim, J. (2023) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2022.0118 · Cited by 17 · see citing works

Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence

Zhang, J., Ma, B., Wang, Z., Chen, Y., Li, C., & Dong, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01292-0 · Cited by 17 · see citing works

Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation

Si, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17 · see citing works

Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology

Raimondi, L., De Luca, A., Giavaresi, G., Raimondo, S., Gallo, A., Taiana, E., Alessandro, R., Rossi, M., Neri, A., Viglietto, G., et al. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030037 · Cited by 16 · see citing works

Extracellular Vesicle Levels of Nervous System Injury Biomarkers in Critically Ill Trauma Patients with and without Traumatic Brain Injury

Guedes, V. A., Mithani, S., Williams, C., Sass, D., Smith, E. G., Vorn, R., Wagner, C., Lai, C., Gill, J., & Hinson, H. E. (2022) · Neurotrauma Reports · doi:10.1089/neur.2022.0058 · Cited by 15 · see citing works

Mesenchymal stem cell-derived exosomes affect macrophage phenotype: a cell-free strategy for the treatment of skeletal muscle disorders

Su, G., Lei, X., Wang, Z., Xie, W., Wen, D., & Wu, Y. (2023) · Current Molecular Medicine · doi:10.2174/1566524022666220511123625 · Cited by 10 · see citing works

Extracellular Vesicles and Their Interplay with Biological Membranes

Yeo Xian Ping, J., Raj Neupane, Y., & Pastorin, G. (2022) · Physiology · doi:10.5772/intechopen.101297 · Cited by 9 · see citing works

Optimized Wound Healing Assay to Study Extracellular Vesicle-Driven Glioblastoma Cell Migration

D’Antonio, C., Mantile, F., Pocsfalvi, G., & Liguori, G. L. (2026) · Methods and Protocols · doi:10.3390/mps9030081

Lipid Droplets Fuel Small Extracellular Vesicle BiogenesisPreprint

Genard, G. C., Tirinato, L., Pagliari, F., Silva, J. D., Giammona, A., Alquraish, F., Bordas, M., Marafioti, M. G., Franco, S. D., Janssen, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513202 · Cited by 1 · see citing works

[Research progress on the molecular regulatory mechanism of exosome biogenesis].

Duan, H., Gan, L., & Cao, Y. (2022) · PubMed · doi:10.3760/cma.j.cn121430-20210818-01209

Exosome Extracellular Vesicles: A Vehicle for Simultaneous Immune and Genetic Therapy

(2020) · doi:10.31038/mip.2020121 · Cited by 1 · see citing works

[RETRACTED] Methods for HIV Promotes Atherosclerosis via Circulating Extracellular Vesicle microRNAs v1Preprint

Wei, J. (2021) · doi:10.17504/protocols.io.bwirpcd6

Exosome Profiling Pinpoints Cancer Type

(2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-nb2020-083 · Cited by 3 · see citing works