Matrix molecules and skin biology
Abstract
An extracellular matrix (ECM) is a prerequisite for multicellular life. It is adapted to tissues and constantly undergoes changes to preserve microenvironmental homeostasis. The ECM acts as a structural scaffold that establishes tissue architecture and provides tensile strength. It has cell-instructive functions by serving as a reservoir and presenter of soluble agents, being directly signaling, integrating transmission of mechanical and biological cues, or serving as a co-factor potentiating signaling. The skin contains a highly developed, mechanically tough, but yet flexible ECM. The tissue-specific features of this ECM are largely attributed by minor ECM components. A large number of genetic and acquired ECM diseases with skin manifestations, provide an illustrative testament to the importance of correct assembly of the ECM for dermal homeostasis. Here, we will present the composition and features of the skin ECM during homeostasis and regeneration. We will discuss genetic and acquired ECM diseases affecting skin, and provide a short outlook to therapeutic strategies for them.
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ECM acts as a molecular reservoir of biological factors, e.g., growth factors, to enhance cell signaling.
“In addition to its structural role in tissue architecture, ECM acts as a molecular reservoir of biological factors, e.g., growth factors, to enhance cell signaling [12].”
Cites
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- Authors
- Nyström, A., & Bruckner-Tuderman, L.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Nyström, Alexander
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 89
- Pages
- 136-146
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2887183837
- Cited by
- 144
- References
- 4
- Citations by year
- 2026: 7 · 2025: 28 · 2024: 23 · 2023: 17 · 2022: 24 · 2021: 15 · 2020: 19 · 2019: 10 · 2018: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Research Foundation, DFG
- Debra international
- (grant Nystrom Bruckner-Tuderman 1)
- German Federal Ministry for Education and Research, BMBF, under the frame of Erare-4,
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- extracellular matrix, skin, skin regeneration, matrix assembly, mechanical signaling, dermis, treatment options
- MeSH terms
- Extracellular Matrix, Homeostasis, Humans, Regeneration, Skin, Wound Healing, Cellular Microenvironment
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