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Metabolic pathways regulating colorectal cancer initiation and progression
Open accessAbstract
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the need for a better understanding of the underlying mechanisms accounting for tumor initiation and progression. Recently, deregulation of cellular metabolism has emerged as a key hallmark of cancer. Reprogramming of core cellular metabolic pathways by cancer cells provides energy, anaplerotic precursors and reducing equivalents required to support tumor growth. Here, we review key findings implicating cancer metabolism as a major contributor of tumor initiation, growth and metastatic dissemination in CRC. We summarize the metabolic pathways governing stem cell fate in the intestine, the metabolic adaptations of proliferating colon cancer cells and their crosstalk with oncogenic signaling, and how they fulfill the energetic demands imposed by the metastatic cascade. Lastly, we discuss how some of these metabolic pathways could represent new vulnerabilities of CRC cells with the potential to be targeted.
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“Indeed, KRAS mutant CRC harbors a boosted glucose metabolism as well as deregulation of glutamine, amino-acid, and fatty acid metabolism that support cancer cell proliferation [48].”
From KRAS, a New Target for Precision Medicine in Colorectal Cancer? (2024) · cites this paper as [48]
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Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,044
Global cancer statistics, 2012
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21262 · Cited by 26,858
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
Ferlay, J., Steliarova‐Foucher, E., Lortet‐Tieulent, J., Rosso, S., Coebergh, J. W. W., Comber, H., Forman, D., & Bray, F. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.12.027 · Cited by 5,243
The consensus molecular subtypes of colorectal cancer
Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3967 · Cited by 5,170
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Identification and expansion of human colon-cancer-initiating cells
Ricci‐Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & Maria, R. D. (2006) · Nature · doi:10.1038/nature05384 · Cited by 4,001
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Items 101–200 of 348
Targeting the Metabolic Adaptation of Metastatic Cancer
Tarragó‐Celada, J., & Cascante, M. (2021) · Cancers · doi:10.3390/cancers13071641 · Cited by 19
Lee, K., Wu, K., Yen, C., Chen, C., Chang, S., & Huang, W. (2021) · Life · doi:10.3390/life11101067 · Cited by 19
Mitochondria govern histone acetylation in colorectal cancer
Ohshima, K., Oi, R., Nojima, S., & Morii, E. (2021) · The Journal of Pathology · doi:10.1002/path.5818 · Cited by 21
Babaei‐Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A. K., Kattan, S. W., Mansouri, O. A., Mukherjee, A., Lobo, D. N., & Nateri, A. S. (2022) · Oncogenesis · doi:10.1038/s41389-021-00376-1 · Cited by 20
Zheng, L., Chen, X., Zhang, L., Qin, N., An, J., Zhu, J., Jin, H. D., & Tuo, B. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5554 · Cited by 19
Itraconazole inhibits tumor growth via CEBPB‐mediated glycolysis in colorectal cancer
Zhang, Y., Li, L., Chu, F., Wu, H., Xiao, X., Ye, J., & Li, K. (2024) · Cancer Science · doi:10.1111/cas.16082 · Cited by 19
Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer
Colloca, A., Balestrieri, A., Anastasio, C., Balestrieri, M. L., & D’Onofrio, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063212 · Cited by 19
Khan, M. Z. I., Tam, S. Y., Azam, Z., & Law, H. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104600 · Cited by 18
Li, C., Cai, D., Zhong, M., Lv, M., Huang, Z.-P., Zhu, Q., Hu, C., Qi, H., Wu, X., & Gao, F. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.880093 · Cited by 18
Xiao, Y., Zhang, G., Wang, L., & Liang, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1069528 · Cited by 18
Wang, W., Xu, X., Zhao, L., Ye, K., Wang, S., & Lin, C. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2247248 · Cited by 17
Curcumin-shellac nanoparticle-loaded GelMA/SilMA hydrogel for colorectal cancer therapy
Zhang, B., Yan, J., Jin, Y. C., Yang, Y., & Zhao, X. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114409 · Cited by 19
Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., Juárez, M., Lai, D., Hua, S., Tovar, A. R., Díaz‐Chávez, J., & Dueñas‐González, A. (2020) · Oncology Letters · doi:10.3892/ol.2020.11838 · Cited by 19
Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer
Radanova, M. A., Mihaylova, G., Nazifova-Tasinova, N. F., Levkova, M., Tasinov, O., Ivanova, D. P., Mihaylova, Z., & Donev, I. S. (2021) · Cancers · doi:10.3390/cancers13143395 · Cited by 16
Hao, Y., Li, Z., Chang, M., & Zhang, X. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s384151 · Cited by 16
Guo, L., Zhang, B., Zhang, W., Xie, Y., Chen, X., Sun, X., Watt, D. S., Liu, C., Spielmann, H. P., & Liu, X. (2024) · Cancers · doi:10.3390/cancers16071399 · Cited by 16
Ciftci, H. I., Sever, B., Bayrak, N., Yıldız, M., Yıldırım, H., Tateishi, H., Otsuka, M., Fujita, M., & Tuyun, A. F. (2022) · Pharmaceuticals · doi:10.3390/ph15101266 · Cited by 15
Multi-omics analysis of fecal samples in colorectal cancer Egyptians patients: a pilot study
Khattab, R. H., Abo-Hammam, R. H., Salah, M., Hanora, A., Shabayek, S., & Zakeer, S. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02991-x · Cited by 15
Wang, D., Woodcock, E., Yang, X., Nishikawa, H., Sviderskaya, E. V., Oshima, M., Edwards, C., Zhang, Y., & Korchev, Y. E. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.04.004 · Cited by 15
Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma
Yao, H., Liu, P., Yao, L., & Li, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03374-6 · Cited by 15
Woldmar, N., Schwendenwein, A., Kuras, M., Szeitz, B., Boettiger, K., Tisza, A., László, V., Reiniger, L., Bagó, A. G., Szállási, Z., et al. (2022) · ESMO Open · doi:10.1016/j.esmoop.2022.100741 · Cited by 15
Jia, L., Liao, L., Jiang, Y., Hu, X., Lu, G., Xiao, W., Gong, W., & Jia, X. (2023) · BMC Cancer · doi:10.1186/s12885-023-11519-5 · Cited by 14
Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer
Zhang, X., Dong, Z., & Cui, H. (2021) · Biomolecules · doi:10.3390/biom11101406 · Cited by 14
CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis
Li, J., Zheng, W., Wu, J., Zhang, J., Lv, B., Li, W., Liu, J., Zhang, X., Huang, T., & Luo, Z. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023041 · Cited by 14
Li, L.-D., & Ma, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-00410-7 · Cited by 13
Novel drug delivery systems in colorectal cancer: Advances and future prospects
Kamal, R., Awasthi, A., Paul, P., Mir, M. S., Singh, S. K., & Dua, K. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155546 · Cited by 14
Zhang, G., Shen, L., Li, Z., & Zhao, Y. (2023) · Aging · doi:10.18632/aging.204772 · Cited by 12
Shao, X., Li, J., Shao, Q., Qu, R., Ouyang, X., Wang, Y., & Chen, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-72797-y · Cited by 12
Flores-García, L. C., García-Castillo, V., Pérez-Toledo, E., Trujano-Camacho, S., Millán-Catalán, O., Pérez-Yépez, E.-A., Coronel-Hernández, J., Rodríguez‐Dorantes, M., Jacobo-Herrera, N. J., & Pérez‐Plasencia, C. (2025) · Cells · doi:10.3390/cells14050388 · Cited by 12
Mahbub, A. A. (2022) · Life · doi:10.3390/life12040605 · Cited by 12
Liu, J., Li, Y., Xiao, Q., Li, Y., Peng, Y., Gan, Y., Shu, G., Yi, H., & Yin, G. (2022) · BMC Cancer · doi:10.1186/s12885-022-10126-0 · Cited by 13
KRAS, a New Target for Precision Medicine in Colorectal Cancer?
Boilève, A., Smolenschi, C., Lambert, A., Boige, V., Delaye, M., Camilleri, G. M., Tarabay, A., Valéry, M., Fuerea, A., Pudlarz, T., et al. (2024) · Cancers · doi:10.3390/cancers16203455 · Cited by 11
Varghese, E., Samuel, S. M., Horňák, S., Kubatka, P., & Büsselberg, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.052 · Cited by 11
Role of Post-Translational Modifications in Colorectal Cancer Metastasis
Peng, N., Liu, J., Hai, S., Liu, Y., Zhao, H., & Liu, W. (2024) · Cancers · doi:10.3390/cancers16030652 · Cited by 11
Safari, F., Jalalian, Y., Abdouss, H., Pourmadadi, M., Zahedi, P., Abdouss, M., Rahdar, A., Fathi‐karkan, S., & Pandey, S. (2024) · BioNanoScience · doi:10.1007/s12668-024-01376-2 · Cited by 11
UPLC-Q-TOF/MS-based urine metabolomics for the diagnosis and staging of bladder cancer
Shi, X., Zheng, W., He, B., Huang, L., Zhong, Q., Yang, Y., Zhou, T., & Huang, Y. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120022 · Cited by 11
Taank, Y., & Agnihotri, N. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02686-7 · Cited by 12
Cao, Z., Lin, J., Fu, G., Niu, L., Yang, Z., & Cai, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959967 · Cited by 11
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Guo, S., Song, B., Lin, L., He-sheng, L., Yang, T., Cao, L., & Wang, J. (2023) · Journal of Immunology Research · doi:10.1155/2023/9011232 · Cited by 11
Ding, R., Chen, T., Zhang, Y., Chen, X., Zhuang, L., & Yang, Z. (2021) · Science Progress · doi:10.1177/00368504211031749 · Cited by 11
Yildirim, H. C., Gunenc, D., Almuradova, E., Sutcuoglu, O., & Yalcin, S. (2025) · Medicina · doi:10.3390/medicina61030408 · Cited by 10
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Fang, Q., Lin, J., Gao, L., Pan, R., & Zheng, X. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2127603 · Cited by 10
Liu, S., Zhou, Y., Chen, Y., Qiao, Y., Bai, L., Zhang, S., Men, D., Zhang, H., Pan, F., Gao, Y., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112828 · Cited by 10
Xie, Y., Li, H., Pan, J., Li, Y., & Zhang, D. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.117443 · Cited by 10
Mao, G., Wu, J., Cui, H., Dai, L., Ma, L., Zhou, Z., Liang, B., Zhang, S., & Lin, S. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s351831 · Cited by 10
Mahajan, M., Sarkar, A., & Mondal, S. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00719-6 · Cited by 10
Ciftci, H. I., Sever, B., Kaya, N., Bayrak, N., Yıldız, M., Yıldırım, H., Tateishi, H., Otsuka, M., Fujita, M., & Tuyun, A. F. (2022) · Molecules · doi:10.3390/molecules28010077 · Cited by 10
Tu, M., Yin, X., Zhuang, W., Lin, X., Xia, Y., Huang, Z. L., Zheng, Y., & Huang, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01694-6 · Cited by 9
Wang, Z., Zhang, Y., Yang, X., Zhang, T., Li, Z., Zhong, Y., Fang, Y., Chong, W., Chen, H., & Lü, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-56391-w · Cited by 9
Wu, Z., Zou, J., Xie, H., Wang, J., Huang, Y., Liu, F., & Xing, C. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70103 · Cited by 9
Hsu, C., El‐Sehrawy, A. A. M. A., Baig, M. R., Al-Khafaji, Z. K. A., Saidaloevich, M. S., Patel, P. N., Ganesan, S., Arora, V., Shukla, S. K., & Nayak, P. P. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114867 · Cited by 12
Feng, C., Pan, L.-X., Tang, S., He, L., Wang, X., Tao, Y., Xie, Y., Lai, Z., Tang, Z., Wang, Q., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.695662 · Cited by 9
Colombo, G., Gelardi, E. L. M., Balestrero, F. C., Moro, M., Travelli, C., & Genazzani, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.758320 · Cited by 9
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Xiong, B., Xie, Z., Song, F., Chen, H., Wang, X., Jin, Z., Han, T., Li, Y., & Zhang, D. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022038 · Cited by 9
Castrogiovanni, P., Barbagallo, I. A., Imbesi, R., Musumeci, G., Sanfilippo, C., Broggi, G., Caltabiano, R., Tibullo, D., Giallongo, C., Forte, S., et al. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154038 · Cited by 8
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Oryani, M. A., Tavasoli, A., Ghalavand, M. A., Ashtiani, R. Z., Rezaee, A., Mahmoudi, R., Golvari, H., Owrangi, S., & Soleymani-Goloujeh, M. (2022) · Epigenomics · doi:10.2217/epi-2022-0067 · Cited by 9
Beena, T., Jesil, M. A., & Harikumar, K. B. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109500 · Cited by 9
Zhang, S., Xu, R., Hu, M., Choueiry, F., Jin, N. Y., Li, J., Mo, X. M., & Zhu, J. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.115978 · Cited by 8
Alhosani, F., Alhamidi, R. S., İlçe, B. Y., Altaie, A. M., Ali, N., Hamad, A. M., Künstner, A., Khandanpour, C., Busch, H. S., al-Ramadi, B. K., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094194 · Cited by 8
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Alshakarchi, H. I., Azari, H., Jeddoa, Z. M. A., Jafar, N. N. A., Khazaei, Y., Gataa, I. S., Ferns, G. A., & Avan, A. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128341167250520063502 · Cited by 8
Zhang, X., Sun, P., Yang, W., Li, S., Jia, H., Wang, W., Jiang, S., Wang, L., Liu, X., Liang, L., et al. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153996 · Cited by 8
MAN2A1 predicts prognosis and progression through cancer-related pathways in colorectal cancer
Wang, Y., Zhao, J., Fu, G., Sheng, C., Zhu, J. X., Zhong, T., Yang, F., & Jiang, Z. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-629 · Cited by 7
Ye, M., Li, X., Chen, L., Mo, S., Liu, J., Huang, T., Luo, F., & Zhang, J. (2023) · Cancers · doi:10.3390/cancers15030592 · Cited by 10
Cao, Y., Dai, Z., Xie, G., Liu, G., Guo, L., & Zhang, J. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113628 · Cited by 8
Liang, Y., Li, R., Bao, S., Li, Z.-L., Yin, H., & Dai, C. (2023) · Human Gene Therapy · doi:10.1089/hum.2023.046 · Cited by 8
Lin, G., Dong, L., Cheng, K., Xu, X., Wang, Y., Deng, L., Raftery, D., & Dong, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02246 · Cited by 8
Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data
Agapito, G., & Cannataro, M. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04297-z · Cited by 8
Wang, G., Wang, J., Xu, X.-N., Shi, F., & Fu, X.-L. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2071909 · Cited by 8
Robson, J. L., Thorn, R. M. S., Williams, A. C., Collard, T. J., & Qualtrough, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-44130-6 · Cited by 8
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Zaurito, A. E., & Tschurtschenthaler, M. (2022) · Metabolites · doi:10.3390/metabo12010046 · Cited by 8
Chung, K., Heo, S.-W., Lee, J.-H., Han, H.-S., Kim, G.-H., Kim, Y.-R., Kim, M.-S., Hong, J.-E., Rhee, K., & Lee, K. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114734 · Cited by 7
Li, J., Liu, Z., Zhang, B., You, L., & Huang, Y. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04173-2 · Cited by 7
The identification of novel stroke-related sphingolipid biomarkers using UPLC-MS/MS
Yang, Z., Deng, X., Zhu, J., Chen, S., Jiao, C., & Ruan, Y. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117652 · Cited by 7
Liu, J., Zhang, F., Zhong, J., & Zheng, Z. G. (2022) · Disease Markers · doi:10.1155/2022/3201600 · Cited by 7
RUNX1 regulates MCM2/CDC20 to promote COAD progression modified by deubiquitination of USP31
Tian, W., Zhao, J., Zhang, X., Li, P., Li, X., Yuan, H., & Li, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-64726-w · Cited by 6
Lactylation in colorectal cancer: From mechanism to clinical application
Chen, P., Gao, Y., Xie, S.-X., & Lei, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117621 · Cited by 6
Ras Family of Small GTPases in CRC: New Perspectives for Overcoming Drug Resistance
Río-Vilariño, A., del Puerto‐Nevado, L., García‐Foncillas, J., & Cebrián, A. (2021) · Cancers · doi:10.3390/cancers13153757 · Cited by 6
Chen, Z., Wang, Q., Liu, J., Wang, W., Yuan, W., Liu, Y., Sun, Z., & Wang, C. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.011 · Cited by 6
Beton-Mysur, K., Surmacki, J. M., & Brożek-Płuska, B. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.124242 · Cited by 6
Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
Wu, Q., Zhang, Z., Chen, Y., Jiang, C., Jiang, Y., Zhu, D., & Wei, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.736678 · Cited by 6
Sugai, T., Osakabe, M., Niinuma, T., Eizuka, M., Tanaka, Y., Yamada, S., Yanagawa, N., Otsuka, K., Sasaki, A., Matsumoto, T., et al. (2021) · Genes Chromosomes and Cancer · doi:10.1002/gcc.23016 · Cited by 6
Huang, X., Chen, L., & Liu, X. (2025) · Research · doi:10.34133/research.0743 · Cited by 5
Chen, H., Wang, Z., Sun, C., Zhong, Y., Liu, Y., Li, Y., Zhang, T., Zhang, Y., Zhu, X., Li, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202501333 · Cited by 5
Leung, H. K. M., Lo, E. K. K., Chen, C., Zhang, F., Felicianna, Ismaiah, M. J., & El-Nezami, H. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-11820-2 · Cited by 5
Albukhari, A. F. (2025) · Journal of Toxicology · doi:10.1155/jt/5569113 · Cited by 6
Cesare, F. D., Vignoli, A., Luchinat, C., Tenori, L., & Saccenti, E. (2023) · Metabolites · doi:10.3390/metabo13020296 · Cited by 5
Bersano, J., Lashuk, K., Edinger, A., & Schüler, J. B. (2023) · Cells · doi:10.3390/cells12212539 · Cited by 5
Wang, F., Yin, J., Wang, X., Zhang, H., Song, Y., Zhang, X., & Wang, T. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175040 · Cited by 5
Tsai, H.-Y., Chen, M.-H., Yun, J., Lai, L. A., John, V., Bronner, M. P., Brentnall, T. A., Pan, S., & Chen, R. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217977 · Cited by 11
Basnet, U., Patil, A. R., Kulkarni, A., & Roy, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115525 · Cited by 5
Borrego, A., Jensen, J. R., Cabrera, W. H. K., Massa, S., Ribeiro, O. G., Starobinas, N., Franco, M. D., Eto, S. F., Manenti, G., Dragani, T. A., et al. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00159-z · Cited by 4
Zheng, Y., Wu, R., Wang, X., & Yin, C. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.860381 · Cited by 5
Liao, L., Gao, Y., Su, J., & Ye, F. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.822835 · Cited by 5
Gu, P., & Wu, L. (2023) · Nutrition and Cancer · doi:10.1080/01635581.2023.2178923 · Cited by 5
Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review
Wu, Y., Mou, J., Liu, Y., & Zheng, W. (2023) · Medicine · doi:10.1097/md.0000000000035631 · Cited by 5
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging
Malviya, G., Lannagan, T. R. M., Johnson, E. R., Mackintosh, A., Bielik, R., Peters, A., Soloviev, D., Brown, G. D., Jackstadt, R., Nixon, C., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1063 · Cited by 5
The key target and role of betel nut in oral squamous cell carcinoma
Zhang, T., Xiong, H., Zeng, L., Yang, Z., Hu, X., & Su, T. (2025) · BMC Oral Health · doi:10.1186/s12903-025-06558-2 · Cited by 4
Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation
Lin, J., Yin, Y., Cao, J., Zou, B., Han, K., Chen, Y., Li, S., Huang, C., Chen, J., Lv, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202410058 · Cited by 5
Pan-RAS inhibitors and polo-like kinase 1: promising targets in colorectal cancer
Jayachandran, P., Elliott, A., Soni, S., Battaglin, F., Mittal, P., Algaze, S. D., Lo, J. H., Yang, Y., Ashouri, K., Torres, E. T. R., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03484-z · Cited by 6
Matsuyama, N., Konishi, T., Takayashiki, T., Takano, S., Suzuki, D., Sakai, N., Hosokawa, I., Mishima, T., Suzuki, K., Nishino, H., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71027 · Cited by 4
Metadata
- Authors
- La Vecchia, S., & Sebastián, C.
- Affiliations
- Candiolo Cancer Institute (IT)
- Corresponding author
- Sebastián, Carlos
- ORCID
- Sebastián, Carlos
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 98
- Pages
- 63-70
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2947351976
- Cited by
- 349
- References
- 105
- Citations by year
- 2026: 26 · 2025: 49 · 2024: 68 · 2023: 70 · 2022: 66 · 2021: 43 · 2020: 22
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- FPRC 5 per mille 2011 MIUR
- FPRC 5 per mille 2014 MIUR
- RC 2018 Ministero della Salute
- European Union’s Horizon 2020 Research and Innovation Program (797464)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- colorectal cancer, cancer metabolism, tumor initiation, tumor progression, metabolic reprogramming, intestinal stem cells, colon cancer cells, oncogenic signaling, metastasis, metabolic vulnerability, therapeutic target
- MeSH terms
- Animals, Humans, Colorectal Neoplasms, Disease Progression, Metabolic Networks and Pathways, Cellular Reprogramming
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