Cited by 349Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

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Metabolic pathways regulating colorectal cancer initiation and progression

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La Vecchia, Sofia, Sebastián, Carlos·2020·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2019.05.018

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Abstract

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the need for a better understanding of the underlying mechanisms accounting for tumor initiation and progression. Recently, deregulation of cellular metabolism has emerged as a key hallmark of cancer. Reprogramming of core cellular metabolic pathways by cancer cells provides energy, anaplerotic precursors and reducing equivalents required to support tumor growth. Here, we review key findings implicating cancer metabolism as a major contributor of tumor initiation, growth and metastatic dissemination in CRC. We summarize the metabolic pathways governing stem cell fate in the intestine, the metabolic adaptations of proliferating colon cancer cells and their crosstalk with oncogenic signaling, and how they fulfill the energetic demands imposed by the metastatic cascade. Lastly, we discuss how some of these metabolic pathways could represent new vulnerabilities of CRC cells with the potential to be targeted.

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Authors: La Vecchia, S., & Sebastián, C.
Affiliations: Candiolo Cancer Institute (IT)
Corresponding author: Sebastián, Carlos
ORCID: Sebastián, Carlos
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2020-02
Volume: 98
Pages: 63-70
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2019.05.018
OpenAlex: W2947351976
Cited by: 349
References: 105
Citations by year: 2026: 26 · 2025: 49 · 2024: 68 · 2023: 70 · 2022: 66 · 2021: 43 · 2020: 22
FWCI: 3.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Seminars in Cell and Developmental Biology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
Funders: FPRC 5 per mille 2011 MIUR
FPRC 5 per mille 2014 MIUR
RC 2018 Ministero della Salute
European Union’s Horizon 2020 Research and Innovation Program (797464)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: colorectal cancer, cancer metabolism, tumor initiation, tumor progression, metabolic reprogramming, intestinal stem cells, colon cancer cells, oncogenic signaling, metastasis, metabolic vulnerability, therapeutic target
MeSH terms: Animals, Humans, Colorectal Neoplasms, Disease Progression, Metabolic Networks and Pathways, Cellular Reprogramming

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Metabolic pathways regulating colorectal cancer initiation and progression

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