From epigenotype to new genotypes: Relevance of epigenetic mechanisms in the emergence of genomic evolutionary novelty
Abstract
A fundamental question in evolutionary biology is how heritable variability originates. In Darwinian evolution a central focus was placed on the thinking that random variations are the material basis for the action of natural selection. Although randomness in Darwinian evolution can be interpreted from different angles, here I will focus on the assumption of equiprobability of mutations. I have reviewed the literature regarding epigenetic mechanisms causing biased genetic variability. Although it is interesting to find correlations between somatic epigenetic marks and evolution, causation between epigenetic changes and genomic evolutionary novelties can only be established when the epigenetic changes are interrogated in the germ line. Epigenetic changes are reported to influence the emergence of single nucleotide polymorphisms and copy number variations. On the other hand, epigenetic changes are known to be influenced by environmental exposures. This dual ability of epigenetic changes could mean that germ line epigenetically influenced mutations could have an important role in the emergence of genomic evolutionary novelties. The emergent knowledge on the relation of epigenetic changes and mutations will help to understand an underappreciated role of the environment in speciation and genomic divergence: that of influencer of genomic changes.
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By promoting genetic mutations and by transitioning into the germline during development, environmentally induced epigenetic marks are suggested to contribute to an inheritance of acquired traits and thus promote natural selection in a neo-Lamarckian way potentially facilitating neo-Darwinian evolution.
“By promoting genetic mutations and by transitioning into the germline during development, environmentally induced epigenetic marks are suggested to contribute to an 'inheritance of acquired traits' and thus promote natural selection in a neo-Lamarckian way potentially facilitating neo-Darwinian evolution (Guerrero-Bosagna, 2019;Skinner, 2015).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Guerrero-Bosagna, 2019
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Origin and Evolution of Biodiversity
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Retrotransposons: Genomic and Trans-Genomic Agents of Change
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Simmons, M. J., Peterson, M. P., THORP, M. W., Buschette, J. T., DiPrima, S., Harter, C. L., & Skolnick, M. J. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.01.011 · Cited by 5 · see citing works
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Self-citation
Flagged first, then by citations
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Schiele, M. A., Gottschalk, M. G., & Domschke, K. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101830 · Cited by 156 · see citing works
Present and future challenges for the investigation of transgenerational epigenetic inheritance
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The methylation landscape and its role in domestication and gene regulation in the chicken
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The epigenetic basis of evolution
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Hologenomic interactions promote the higher-order evolvability of phenotypic complexity
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- Authors
- Guerrero-Bosagna, C.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 97
- Pages
- 86-92
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2958570119
- Cited by
- 26
- References
- 111
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Research Council
- Svenska Forskningsrådet Formas
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- epigenetic inheritance, single nucleotide polymorphisms, copy number variation, speciation, genomic divergence
- MeSH terms
- Biological Evolution, Genotype, Humans, Genomics, Epigenesis, Genetic
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