Cited by 148Cancer survivorship and carePhysical Activity and HealthExercise and Physiological Responses

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Exercise as Adjunct Therapy in Cancer

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Ashcraft, Kathleen A., Warner, Allison Betof, Jones, Lee W., Dewhirst, Mark W.·2019·Seminars in Radiation Oncology

DOI 10.1016/j.semradonc.2018.10.001PMC PMC6656408

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Abstract

Data from observational studies indicate that both physical activity as well as exercise (ie, structured physical activity) is associated with reductions in the risk of recurrence and cancer mortality after a diagnosis of certain forms of cancer. Emerging evidence from preclinical studies indicates that physical activity/exercise paradigms regulate intratumoral vascular maturity and perfusion, hypoxia, and metabolism and augments the antitumor immune response. Such responses may, in turn, enhance response to standard anticancer treatments. For instance, exercise improves efficacy of chemotherapeutic agents, and there is rationale to believe that it will also improve radiotherapy response. This review overviews the current preclinical as well as clinical evidence supporting exercise modulation of therapeutic response and postulated biological mechanisms underpinning such effects. We also examine the implications for tumor response to radiation, chemotherapy, and immunotherapy.

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Authors: Ashcraft, K. A., Warner, A. B., Jones, L. W., & Dewhirst, M. W.
Affiliations: Duke University (US)
Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Dewhirst, Mark W.
ORCID: Ashcraft, Kathleen A.
Warner, Allison Betof
Jones, Lee W.
Dewhirst, Mark W.
Venue: Seminars in Radiation Oncology
Publisher: Elsevier BV
Published: 2019-01
Volume: 29
Issue: 1
Pages: 16-24
ISSN: 1053-4296 (ISSN-L)
DOI: 10.1016/j.semradonc.2018.10.001
PMC: PMC6656408
OpenAlex: W2905164432
Cited by: 148
References: 108
Citations by year: 2026: 14 · 2025: 22 · 2024: 15 · 2023: 19 · 2022: 23 · 2021: 20 · 2020: 25 · 2019: 9
FWCI: 1.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Radiation Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P30CA008748)
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: physical activity, tumor recurrence, cancer mortality, tumor hypoxia, tumor vascularization, cancer metabolism, antitumor immunity, chemotherapy response, radiotherapy response, immunotherapy response
MeSH terms: Antineoplastic Agents, Combined Modality Therapy, Exercise Therapy, Humans, Immunotherapy, Neoplasms, Radiotherapy

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