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Blood pressure disorders in the neonate: Hypotension and hypertension
Abstract
Although many sick newborns are treated for hypotension and hypertension, the normal physiologic blood pressure range ensuring appropriate organ perfusion is uncertain. Treatment decisions are based on statistically defined gestational and postnatal age-dependent normative blood-pressure values, combined with clinical intuition, because of difficulties evaluating organ perfusion and adequacy of cerebral oxygen delivery. Early-onset hypotension usually results from the combined effects of abnormal peripheral vasoregulation, myocardial dysfunction, and hypovolemia. Volume administration is the primary initial therapy but its use can be associated with significant untoward effects, especially in preterm infants, and should be limited to 10-20 mL/kg of isotonic saline. If the blood pressure cannot be normalized, dopamine should be added, and sometimes followed by adrenaline (epinephrine) and corticosteroids. Hypertension, most often caused by congenital or acquired renovascular disease or volume overload, needs a thorough search for the etiology and cautious treatment, so that blood pressure does not fall too quickly or too low.
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“Blood pressure is an essential physiological marker of perfusion, autonomic function, and vascular tone for critically ill newborns (31).”
From Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care (2019) · cites this paper as [31]
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Metadata
- Authors
- Fanaroff, J. M., & Fanaroff, A. A.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Fanaroff, Jonathan M.
- Venue
- Seminars in Fetal and Neonatal Medicine
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 11
- Issue
- 3
- Pages
- 174-181
- ISSN
- 1744-165X (ISSN-L)
- OpenAlex
- W2154680842
- Cited by
- 84
- References
- 26
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 1 · 2014: 7 · 2013: 2 · 2012: 8
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Fetal and Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- neonatal hypotension, neonatal hypertension, organ perfusion, cerebral oxygen delivery, cardiac dysfunction, hypovolemia, fluid resuscitation, dopamine, epinephrine, corticosteroids, renovascular disease, fluid overload, preterm infants
- MeSH terms
- Blood Pressure Determination, Dopamine, Female, Humans, Hypertension, Hypotension, Infant, Newborn, Infant, Newborn, Diseases, Infant, Premature, Diseases, Male, Pregnancy, Reference Values, Infant, Very Low Birth Weight
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