The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Attention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study
Abstract
Background Children diagnosed with attention-deficit/hyperactivity disorder (ADHD), based on Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV) criteria, may also have obstructive sleep apnea (OSA), but it is unclear whether treating OSA has similar results as methylphenidate (MPH), a commonly used treatment for ADHD.Methods This study enrolled 66 school-age children, referred for and diagnosed with ADHD, and 20 healthy controls. Polysomnography (PSG) performed after ADHD diagnosis showed the presence of mild OSA. After otolaryngological evaluation, parents and referring physicians of the children could select treatment of ADHD with MPH, treatment of OSA with adenotonsillectomy or no treatment. Systematic follow-up was performed six months after initiation of treatment, or diagnosis if no treatment. All children had pre- and post-clinical interviews; pediatric, neurologic, psychiatric and neurocognitive evaluation; PSG; ADHD rating scale, child behavior checklist (CBCL) filled out by parents and teacher; test of variables of attention (TOVA); and the quality of life in children with obstructive sleep disorder questionnaire (OSA-18).Results ADHD children had an apnea-hypopnea index (AHI)>1<5 event/hour; 27 were treated with MPH, 25 had adenotonsillectomy, and 14 had no treatment. The surgical and MPH groups improved more than the non-treatment group. When comparing MPH to post-surgery, the PSG and questionnaire sleep variables, some daytime symptoms (including attention span) and TOVA subscales (impulse control, response time and total ADHD score) improved more in the surgical group than the MPH group. The surgical group had an ADHD total score of 21.16+/-7.13 on the ADHD rating scale (ADHD-RS) post-surgery compared to 31.52+/-7.01 pre-surgery (p=0.0001), and the inattention and hyperactivity subscales were also significantly lower (p=0.0001). Finally, the results were significantly different between surgically and MPH-treated groups (ADHD-RS p=0.007). The surgical group also had a TOVA ADHD score lower than -1.8 and close to those obtained in normal controls.Conclusion A low AHI score of >1 considered abnormal is detrimental to children with ADHD. Recognition and surgical treatment of underlying mild sleep-disordered breathing (SDB) in children with ADHD may prevent unnecessary long-term MPH usage and the potential side effects associated with drug intake.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In children with diagnoses of ADHD and OSA, two prospective studies have demonstrated significant improvements in ADHD symptoms, including hyperactivity, following adenotonsillectomy (Chervin et al. 2006; Huang et al. 2007).”
From Associations of sleep disturbance with ADHD: implications for treatment (2015) · cites this paper as Huang et al. 2007
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment
Barkley, R. A., & Poillion, M. J. (1994) · Behavioral Disorders · doi:10.1177/019874299401900205 · Cited by 4,635
Manual for the Wechsler intelligence scale for children
Wechsler, D. (1974) · Psychological Corp. eBooks · Cited by 1,303
Standards and Indications for Cardiopulmonary Sleep Studies in Children. American Thoracic Society
(1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564147 · Cited by 1,176
Clinical Practice Guideline: Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome
Pulmonology, S. O. P. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.704 · Cited by 930
Snoring, sleep disturbance, and behaviour in 4-5 year olds.
Ali, N. J., Pitson, D., & Stradling, J. R. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.68.3.360 · Cited by 881
Normal Polysomnographic Values for Children and Adolescents
Marcus, C. L., Omlin, K. J., Basinki, D. J., Bailey, S. L., Rachal, A. B., von Pechmann, W. S., Keens, T. G., & Ward, S. L. D. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1235 · Cited by 808
Clinical Predictors of Obstructive Sleep Apnea
Friedman, M., Tanyeri, H., La Rosa, M., Landsberg, R., Vaidyanathan, K., Pieri, S., & Caldarelli, D. (1999) · The Laryngoscope · doi:10.1097/00005537-199912000-00002 · Cited by 706
A manual of Standardized Terminology
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 632
Research works printed but not linked: 3
- Tzang, 2002, Prevalence of attention-deficit/hyperactivity disorder in a Taiwanese Elementary School, Taiwanese J Psychiatry, 16, 202
- Trommer, 1988, Sleep disturbance in children with attention deficit disorder, Ann Neurol, 24, 322
- Gau, 2004, Average Daily dosage of methylphenidate for children with attention-deficit hyperactivity disorder in a medical center, Taiwanese J Psychiatry, 18, 136
Cited by
Sorted by citations
Diamond, A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143750 · Cited by 13,268
“…& Cheng 2005), sad (Hirt et al. 2008, von Hecker & Meiser 2005), lonely (Baumeister et al. 2002, Cacioppo & Patrick 2008, Campbell et al. 2006, Tun et al. 2012), sleep deprived (Barnes et al. 2012, Huang et al. 2007), or not physically fit (Best 2010, Chaddock et al. 2011, Hillman et al. 2008).”
Sleep and mental disorders: a meta-analysis of polysomnographic research
Baglioni, C., Nanovska, S., Regen, W., Spiegelhalder, K., Feige, B., Nissen, C., Reynolds, C. F., & Riemann, D. (2016) · Psychological Bulletin · doi:10.1037/bul0000053 · Cited by 1,074
Sleep Disordered Breathing in Children in a General Population Sample: Prevalence and Risk Factors
Bixler, E. O., Vgontzas, A. N., Lin, H.-M., Liao, D., Calhoun, S. L., Vela‐Bueno, A., Fedok, F. G., Vlašić, V., & Graff, G. R. (2009) · SLEEP · doi:10.1093/sleep/32.6.731 · Cited by 685
Cortese, S., Faraone, S. V., Konofal, E., & Lecendreux, M. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181ac09c9 · Cited by 637
Associations of sleep disturbance with ADHD: implications for treatment
Hvolby, A. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0151-0 · Cited by 339
Metadata
- Authors
- Huang, Y.-S., Guilleminault, C., Li, H.-Y., Yang, C.-M., Wu, Y.-Y., & Chen, N.-H.
- Affiliations
- Chang Gung Memorial Hospital (TW)
- Stanford University (US)
- National Chengchi University (TW)
- Corresponding author
- Guilleminault, Christian
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 8
- Issue
- 1
- Pages
- 18-30
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2130844643
- Cited by
- 202
- References
- 51
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 5 · 2017: 8 · 2016: 14 · 2015: 10 · 2014: 17 · 2013: 16 · 2012: 20
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- attention deficit hyperactivity disorder, obstructive sleep apnea, adenotonsillectomy, methylphenidate, sleep-disordered breathing, apnea-hypopnea index, children, treatment outcomes, inattention, hyperactivity, quality of life, polysomnography, Test of Variables of Attention, ADHD Rating Scale, Child Behavior Checklist, OSA-18
- MeSH terms
- Adenoidectomy, Adenoids, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Disruptive, Impulse Control, and Conduct Disorders, Male, Methylphenidate, Surveys and Questionnaires, Reaction Time, Severity of Illness Index, Sleep Apnea Syndromes, Tonsillectomy, Tonsillitis, Observer Variation, Polysomnography, Sleep Apnea, Obstructive, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
